L-Glutamine 관련 Increased Intestinal Permeability (Leaky Gut)
DSmall studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.
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D
결론
Small studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.
Key Study Findings
Review
Intestinal Barrier Impairment, Preservation, and Repair: An Update.
Dose: None
vs: None
Outcome: Intestinal barrier preservation and repair
효과: None
None
대상 집단: IBD and IBS patients (review)
Other
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.
Dose: None
vs: None
Outcome: Cholesterol levels
효과: None
None
대상 집단: Mouse model
In Vitro
Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …
Dose: None
vs: None
Outcome: inflammation markers
효과: None
None
대상 집단: Mice
Other
Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: None
Systematic Review
Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.
Dose: None
vs: Placebo or standard care
Outcome: IBD symptom improvement
효과: None
None
대상 집단: IBD patients
Controlled Clinical Trial
n=43
4 weeks
Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with …
Dose: 5 g/d
vs: None
Outcome: None
효과: None
None
대상 집단: IBS patients
Key Statistics
2
연구
80
참여자
↑
Positive
D
등급
Referenced Papers
Nutrients
2024
47 인용
Cannabis and cannabinoid …
2024
10 인용
International journal of …
2023
9 인용
Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.
Systematic Review
Clinical nutrition ESPEN
2021
39 인용
Advances in nutrition …
2021
34 인용
Nutrition research (New …
2020
42 인용
Gut
2019
148 인용
Current opinion in …
2017
71 인용
JPEN. Journal of …
2016
44 인용
Glutamine for induction of remission in Crohn's disease.
Systematic Review
The Cochrane database …
2016
37 인용
Gastroenterology
2015
17 인용
Scandinavian journal of …
2014
56 인용
Digestive diseases and …
2012
81 인용
Clinical nutrition (Edinburgh, …
2011
12 인용
MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome.
Other
Gut
2010
263 인용
Clinics (Sao Paulo, …
2010
47 인용
Nutrition in clinical …
2008
42 인용
Clinical nutrition (Edinburgh, …
2005
43 인용
JPEN. Journal of …
2000
18 인용
JPEN. Journal of …
1999
129 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 5-15 g/day
- ibsdsupport:
- 5 g three times daily (15 g/day total)
- postexercisegut:
- 0.25-0.9 g/kg before intense exercise
- gutbarriersupport:
- 0.5 g/kg/day (approximately 30-40 g/day for adults)
상한량: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 5 g/d | 4 weeks | Positive | 43 |
| 5 g | 8.0 weeks | Positive | -- |
| None | -- | Mixed | -- |
권장 복용 시간: Between meals or before exercise; divide doses throughout the day
Safety & Side Effects
보고된 부작용
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Headache
- ⚠ Dizziness at very high doses
- ⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)
알려진 상호작용
- ● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
- ● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
- ● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)
일일 최대 섭취 허용량: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does L-Glutamine help with Increased Intestinal Permeability (Leaky Gut)?
Based on 2 studies with 80 participants, there is preliminary evidence that needs more research that L-Glutamine may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is D (Very Early Research).
How much L-Glutamine should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Glutamine?
Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Glutamine and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 80 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: Increased Intestinal Permeability (Leaky Gut)
L-Glutamine 다른 건강 상태에 대한 근거
FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.