L-Glutamine 用于 肠道通透性增加（肠漏）
D 研究 目前仅存在初步研究（实验室研究、病例报告）。针对运动员的小规模研究显示，谷氨酰胺（0.25至0.9克/公斤）可能减轻运动诱发的肠道通透性增加。
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D
结论
针对运动员的小规模研究显示，谷氨酰胺（0.25至0.9克/公斤）可能减轻运动诱发的肠道通透性增加。
Key Study Findings
Review
Intestinal Barrier Impairment, Preservation, and Repair: An Update.
Dose: None
vs: None
Outcome: Intestinal barrier preservation and repair
效果: None
None
研究人群: IBD and IBS patients (review)
Other
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.
Dose: None
vs: None
Outcome: Cholesterol levels
效果: None
None
研究人群: Mouse model
In Vitro
Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …
Dose: None
vs: None
Outcome: inflammation markers
效果: None
None
研究人群: Mice
Other
Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Systematic Review
Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.
Dose: None
vs: Placebo or standard care
Outcome: IBD symptom improvement
效果: None
None
研究人群: IBD patients
Controlled Clinical Trial
n=43
4 weeks
Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with …
Dose: 5 g/d
vs: None
Outcome: None
效果: None
None
研究人群: IBS patients
Key Statistics
2
研究数量
80
受试者
↑
Positive
D
等级
Referenced Papers
Nutrients
2024
47 次引用
Cannabis and cannabinoid …
2024
10 次引用
International journal of …
2023
9 次引用
Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.
Systematic Review
Clinical nutrition ESPEN
2021
39 次引用
Advances in nutrition …
2021
34 次引用
Nutrition research (New …
2020
42 次引用
Gut
2019
148 次引用
Current opinion in …
2017
71 次引用
JPEN. Journal of …
2016
44 次引用
Glutamine for induction of remission in Crohn's disease.
Systematic Review
The Cochrane database …
2016
37 次引用
Gastroenterology
2015
17 次引用
Scandinavian journal of …
2014
56 次引用
Digestive diseases and …
2012
81 次引用
Clinical nutrition (Edinburgh, …
2011
12 次引用
MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome.
Other
Gut
2010
263 次引用
Clinics (Sao Paulo, …
2010
47 次引用
Nutrition in clinical …
2008
42 次引用
Clinical nutrition (Edinburgh, …
2005
43 次引用
JPEN. Journal of …
2000
18 次引用
JPEN. Journal of …
1999
129 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 5-15 g/day
- ibsdsupport:
- 5 g three times daily (15 g/day total)
- postexercisegut:
- 0.25-0.9 g/kg before intense exercise
- gutbarriersupport:
- 0.5 g/kg/day (approximately 30-40 g/day for adults)
上限： Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 5 g/d | 4 weeks | Positive | 43 |
| 5 g | 8.0 weeks | Positive | -- |
| None | -- | Mixed | -- |
最佳服用时间： Between meals or before exercise; divide doses throughout the day
Safety & Side Effects
已报告的副作用
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Headache
- ⚠ Dizziness at very high doses
- ⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)
已知相互作用
- ● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
- ● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
- ● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)
可耐受最高摄入量： Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does L-Glutamine help with 肠道通透性增加（肠漏）?
Based on 2 studies with 80 participants, there is preliminary evidence that needs more research that L-Glutamine may support 肠道通透性增加（肠漏） management. Our evidence grade is D (Very Early Research).
How much L-Glutamine should I take for 肠道通透性增加（肠漏）?
Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Glutamine?
Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Glutamine and 肠道通透性增加（肠漏）?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 80 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 肠道通透性增加（肠漏）
L-Glutamine 用于其他健康状况
References
- [1] Ayah Matar et al.. Nutrients. 2024. Intestinal Barrier Impairment, Preservation, and Repair: An Update. doi:10.3390/nu16203494 PubMed
- [2] Mengxue He et al.. Cannabis Cannabinoid Res. 2024. Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. doi:10.1089/can.2022.0331 PubMed
- [3] Ludovic D Langlois et al.. Int J Mol Sci. 2023. Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. doi:10.3390/ijms24087220 PubMed
- [4] Juliana Soares Severo et al.. Clin Nutr ESPEN. 2021. Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials. doi:10.1016/j.clnesp.2020.12.023 PubMed
- [5] Mark F McCarty et al.. Adv Nutr. 2021. Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function. doi:10.1093/advances/nmaa139 PubMed
- [6] Karin Ried et al.. Nutr Res. 2020. Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. doi:10.1016/j.nutres.2020.02.008 PubMed
- [7] QiQi Zhou et al.. Gut. 2019. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. doi:10.1136/gutjnl-2017-315136 PubMed
- [8] Najate Achamrah et al.. Curr Opin Clin Nutr Metab Care. 2017. Glutamine and the regulation of intestinal permeability: from bench to bedside. doi:10.1097/MCO.0000000000000339 PubMed
- [9] Julien Bertrand et al.. JPEN J Parenter Enteral Nutr. 2016. Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome. doi:10.1177/0148607115587330 PubMed
- [10] Anthony K Akobeng et al.. Cochrane Database Syst Rev. 2016. Glutamine for induction of remission in Crohn's disease. doi:10.1002/14651858.CD007348.pub2 PubMed
- [11] Moïse Coëffier et al.. Gastroenterology. 2015. Intestinal permeability in patients with diarrhea-predominant irritable bowel syndrome: is there a place for glutamine supplementation? doi:10.1053/j.gastro.2015.02.057 PubMed
- [12] John K Triantafillidis et al.. Scand J Gastroenterol. 2014. The role of total parenteral nutrition in inflammatory bowel disease: current aspects. doi:10.3109/00365521.2013.860557 PubMed
- [13] Jaya Benjamin et al.. Dig Dis Sci. 2012. Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial. doi:10.1007/s10620-011-1947-9 PubMed
- [14] Khaly Mbodji et al.. Clin Nutr. 2011. Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model. doi:10.1016/j.clnu.2011.04.002 PubMed
- [15] QiQi Zhou et al.. Gut. 2010. MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. doi:10.1136/gut.2009.181834 PubMed
- [16] Jean Robert Rapin et al.. Clinics (Sao Paulo). 2010. Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine. doi:10.1590/S1807-59322010000600012 PubMed
- [17] Arnold Wald et al.. Nutr Clin Pract. 2008. Behavioral and complementary approaches for the treatment of irritable bowel syndrome. doi:10.1177/0884533608318677 PubMed
- [18] Jeong Wook Kim et al.. Clin Nutr. 2005. Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. doi:10.1016/j.clnu.2005.04.004 PubMed
- [19] A K Akobeng et al.. JPEN J Parenter Enteral Nutr. 2000. Glutamine supplementation and intestinal permeability in Crohn's disease. doi:10.1177/0148607100024003196 PubMed
- [20] E Den Hond et al.. JPEN J Parenter Enteral Nutr. 1999. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. doi:10.1177/014860719902300107 PubMed
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