Vitamin A 관련 Increased Intestinal Permeability (Leaky Gut)
CRetinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
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C
결론
Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
Key Study Findings
Observational Study
n=54
Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in …
Dose: None
vs: None
Outcome: Intestinal permeability (lactulose:mannitol ratio)
효과: AOR 0.15 (CI 0.05-0.42) for retinol
<0.001
대상 집단: Community-dwelling elderly individuals
Other
12 weeks
Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.
Dose: None
vs: HFD control mice
Outcome: NAFLD biomarkers and gut microbiota composition
효과: None
None
대상 집단: HFD-induced NAFLD mouse model
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
vs: None
Outcome: Athletic performance and nutritional optimization
효과: None
None
대상 집단: Vegan athletes (narrative review)
Observational Study
Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …
Dose: None
vs: None
Outcome: DALYs and mortality rates of congenital birth defects
효과: DALYs decreased 59.77%, deaths decreased 63.81%
None
대상 집단: G20 countries population, 1990-2021
Other
12 weeks
Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and …
Dose: None
vs: None
Outcome: Cognitive function
효과: None
None
대상 집단: Mouse model (APP/PS1)
In Vitro
Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress.
Dose: None
vs: None
Outcome: oxidative stress markers
효과: None
p < 0.05
대상 집단: Chickens
Key Statistics
3
연구
250
참여자
↑
Positive
C
등급
Referenced Papers
BMC pregnancy and …
2025
6 인용
Current nutrition reports
2025
3 인용
NPJ science of …
2025
2 인용
Scientific reports
2025
Frontiers in nutrition
2024
12 인용
Journal of animal …
2023
11 인용
Food science & …
2023
2 인용
International journal of …
2022
60 인용
Journal of Nippon …
2021
26 인용
Frontiers in immunology
2021
8 인용
Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A …
Systematic Review
Psychiatry research
2020
60 인용
Journal of diabetes …
2020
11 인용
Blood
2017
49 인용
ACS chemical neuroscience
2017
20 인용
World journal of …
2016
238 인용
Clinics in dermatology
2016
19 인용
The Journal of …
2015
31 인용
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Other
Journal of pediatric …
2014
38 인용
Nutrition and cancer
2014
5 인용
Blood
2013
54 인용
European journal of …
2012
225 인용
Journal of burn …
2012
16 인용
Medical oncology (Northwood, …
2010
12 인용
Scandinavian journal of …
2010
6 인용
Journal of nutritional …
2010
2 인용
European journal of …
2009
24 인용
Veterinary parasitology
2008
80 인용
Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.
Other
American journal of …
2008
25 인용
European journal of …
2005
2 인용
Journal of health, …
2003
The British journal …
2002
358 인용
Rossiiskii fiziologicheskii zhurnal …
2002
Journal of pediatric …
2001
56 인용
Journal of acquired …
2001
15 인용
The Pediatric infectious …
2000
14 인용
Life sciences
1998
35 인용
Biulleten' eksperimental'noi biologii …
1987
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 700-900 mcg RAE/day (RDA for adults)
- gutbarriersupport:
- 900 mcg RAE/day from mixed sources
- deficiencycorrection:
- 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)
상한량: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Negative | 54 |
| None | 12 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 12 weeks | Negative | -- |
| None | -- | Positive | -- |
| None | 11 weeks | Positive | -- |
| 10 mg/kg | -- | Negative | -- |
권장 복용 시간: With meals containing fat for better absorption
Safety & Side Effects
보고된 부작용
- ⚠ Hepatotoxicity at chronic high doses of preformed vitamin A
- ⚠ Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
- ⚠ Nausea, headache, and dizziness
- ⚠ Bone density reduction with long-term excess
알려진 상호작용
- ● Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
- ● Orlistat (reduces absorption of fat-soluble vitamins)
- ● Alcohol (increases hepatotoxicity risk of vitamin A)
- ● Tetracycline antibiotics (increased risk of intracranial pressure)
일일 최대 섭취 허용량: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Vitamin A help with Increased Intestinal Permeability (Leaky Gut)?
Based on 3 studies with 250 participants, there is limited but promising evidence that Vitamin A may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is C (Some Evidence).
How much Vitamin A should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin A?
Reported side effects may include Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin A and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: Increased Intestinal Permeability (Leaky Gut)
Vitamin A 다른 건강 상태에 대한 근거
FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.