L-Glutamine для Increased Intestinal Permeability (Leaky Gut)

D Исследования Существуют только предварительные исследования (лабораторные исследования, описания случаев).

Small studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.

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Итог

Small studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.

Key Study Findings

Review

Intestinal Barrier Impairment, Preservation, and Repair: An Update.

Dose: None или: None Outcome: Intestinal barrier preservation and repair Эффект: None None

Популяция: IBD and IBS patients (review)

Other

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.

Dose: None или: None Outcome: Cholesterol levels Эффект: None None

Популяция: Mouse model

In Vitro

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …

Dose: None или: None Outcome: inflammation markers Эффект: None None

Популяция: Mice

Other

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function.

Dose: None или: None Outcome: None Эффект: None None

Популяция: None

Systematic Review

Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.

Dose: None или: Placebo or standard care Outcome: IBD symptom improvement Эффект: None None

Популяция: IBD patients

Controlled Clinical Trial n=43 4 weeks

Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with …

Dose: 5 g/d или: None Outcome: None Эффект: None None

Популяция: IBS patients

Key Statistics

Исследования

Участники

↑

Positive

Оценка

Referenced Papers

Intestinal Barrier Impairment, Preservation, and Repair: An Update. Review

Nutrients 2024 47 цитирований

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Other

Cannabis and cannabinoid … 2024 10 цитирований

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 цитирований

Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials. Systematic Review

Clinical nutrition ESPEN 2021 39 цитирований

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function. Other

Advances in nutrition … 2021 34 цитирований

Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. CCT

Nutrition research (New … 2020 42 цитирований

Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. RCT

Gut 2019 148 цитирований

Glutamine and the regulation of intestinal permeability: from bench to bedside. Review

Current opinion in … 2017 71 цитирований

Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome. Other

JPEN. Journal of … 2016 44 цитирований

Glutamine for induction of remission in Crohn's disease. Systematic Review

The Cochrane database … 2016 37 цитирований

Intestinal permeability in patients with diarrhea-predominant irritable bowel syndrome: is there a place for glutamine supplementation? Other

Gastroenterology 2015 17 цитирований

The role of total parenteral nutrition in inflammatory bowel disease: current aspects. Review

Scandinavian journal of … 2014 56 цитирований

Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial. RCT

Digestive diseases and … 2012 81 цитирований

Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model. Other

Clinical nutrition (Edinburgh, … 2011 12 цитирований

MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Other

Gut 2010 263 цитирований

Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine. Review

Clinics (Sao Paulo, … 2010 47 цитирований

Behavioral and complementary approaches for the treatment of irritable bowel syndrome. Review

Nutrition in clinical … 2008 42 цитирований

Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. RCT

Clinical nutrition (Edinburgh, … 2005 43 цитирований

Glutamine supplementation and intestinal permeability in Crohn's disease. RCT

JPEN. Journal of … 2000 18 цитирований

Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. RCT

JPEN. Journal of … 1999 129 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:: 5-15 g/day
ibsdsupport:: 5 g three times daily (15 g/day total)
postexercisegut:: 0.25-0.9 g/kg before intense exercise
gutbarriersupport:: 0.5 g/kg/day (approximately 30-40 g/day for adults)

Верхний предел: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
5 g/d	4 weeks	Positive	43
5 g	8.0 weeks	Positive	--
None	--	Mixed	--

Лучшее время приёма: Between meals or before exercise; divide doses throughout the day

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Mild gastrointestinal discomfort at high doses
⚠ Headache
⚠ Dizziness at very high doses
⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)

Известные взаимодействия

● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)

Допустимый верхний уровень потребления: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does L-Glutamine help with Increased Intestinal Permeability (Leaky Gut)?

Based on 2 studies with 80 participants, there is preliminary evidence that needs more research that L-Glutamine may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is D (Very Early Research).

How much L-Glutamine should I take for Increased Intestinal Permeability (Leaky Gut)?

Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Glutamine?

Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Glutamine and Increased Intestinal Permeability (Leaky Gut)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 80 total participants. The overall direction of effect is positive.

Другие ингредиенты для Increased Intestinal Permeability (Leaky Gut)

Bovine Colostrum B Resistant Starch C Vitamin A C Zinc Carnosine C

L-Glutamine для других состояний

Crohn's Disease C Irritable Bowel Syndrome (IBS) C

References

[1] Ayah Matar et al.. Nutrients. 2024. Intestinal Barrier Impairment, Preservation, and Repair: An Update. doi:10.3390/nu16203494 PubMed
[2] Mengxue He et al.. Cannabis Cannabinoid Res. 2024. Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. doi:10.1089/can.2022.0331 PubMed
[3] Ludovic D Langlois et al.. Int J Mol Sci. 2023. Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. doi:10.3390/ijms24087220 PubMed
[4] Juliana Soares Severo et al.. Clin Nutr ESPEN. 2021. Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials. doi:10.1016/j.clnesp.2020.12.023 PubMed
[5] Mark F McCarty et al.. Adv Nutr. 2021. Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function. doi:10.1093/advances/nmaa139 PubMed
[6] Karin Ried et al.. Nutr Res. 2020. Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. doi:10.1016/j.nutres.2020.02.008 PubMed
[7] QiQi Zhou et al.. Gut. 2019. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. doi:10.1136/gutjnl-2017-315136 PubMed
[8] Najate Achamrah et al.. Curr Opin Clin Nutr Metab Care. 2017. Glutamine and the regulation of intestinal permeability: from bench to bedside. doi:10.1097/MCO.0000000000000339 PubMed
[9] Julien Bertrand et al.. JPEN J Parenter Enteral Nutr. 2016. Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome. doi:10.1177/0148607115587330 PubMed
[10] Anthony K Akobeng et al.. Cochrane Database Syst Rev. 2016. Glutamine for induction of remission in Crohn's disease. doi:10.1002/14651858.CD007348.pub2 PubMed
[11] Moïse Coëffier et al.. Gastroenterology. 2015. Intestinal permeability in patients with diarrhea-predominant irritable bowel syndrome: is there a place for glutamine supplementation? doi:10.1053/j.gastro.2015.02.057 PubMed
[12] John K Triantafillidis et al.. Scand J Gastroenterol. 2014. The role of total parenteral nutrition in inflammatory bowel disease: current aspects. doi:10.3109/00365521.2013.860557 PubMed
[13] Jaya Benjamin et al.. Dig Dis Sci. 2012. Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial. doi:10.1007/s10620-011-1947-9 PubMed
[14] Khaly Mbodji et al.. Clin Nutr. 2011. Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model. doi:10.1016/j.clnu.2011.04.002 PubMed
[15] QiQi Zhou et al.. Gut. 2010. MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. doi:10.1136/gut.2009.181834 PubMed
[16] Jean Robert Rapin et al.. Clinics (Sao Paulo). 2010. Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine. doi:10.1590/S1807-59322010000600012 PubMed
[17] Arnold Wald et al.. Nutr Clin Pract. 2008. Behavioral and complementary approaches for the treatment of irritable bowel syndrome. doi:10.1177/0884533608318677 PubMed
[18] Jeong Wook Kim et al.. Clin Nutr. 2005. Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. doi:10.1016/j.clnu.2005.04.004 PubMed
[19] A K Akobeng et al.. JPEN J Parenter Enteral Nutr. 2000. Glutamine supplementation and intestinal permeability in Crohn's disease. doi:10.1177/0148607100024003196 PubMed
[20] E Den Hond et al.. JPEN J Parenter Enteral Nutr. 1999. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. doi:10.1177/014860719902300107 PubMed

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