L-Glutamine لـ Increased Intestinal Permeability (Leaky Gut)

D الأبحاث توجد أبحاث أولية فحسب (دراسات مختبرية، تقارير حالات).

Small studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.

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الخلاصة

Small studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.

Key Study Findings

Review

Intestinal Barrier Impairment, Preservation, and Repair: An Update.

Dose: None مقابل: None Outcome: Intestinal barrier preservation and repair التأثير: None None

المجتمع المدروس: IBD and IBS patients (review)

Other

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.

Dose: None مقابل: None Outcome: Cholesterol levels التأثير: None None

المجتمع المدروس: Mouse model

In Vitro

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …

Dose: None مقابل: None Outcome: inflammation markers التأثير: None None

المجتمع المدروس: Mice

Other

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: None

Systematic Review

Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.

Dose: None مقابل: Placebo or standard care Outcome: IBD symptom improvement التأثير: None None

المجتمع المدروس: IBD patients

Controlled Clinical Trial n=43 4 weeks

Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with …

Dose: 5 g/d مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: IBS patients

Key Statistics

الدراسات

المشاركون

↑

Positive

التقييم

Referenced Papers

Intestinal Barrier Impairment, Preservation, and Repair: An Update. Review

Nutrients 2024 47 اقتباسات

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Other

Cannabis and cannabinoid … 2024 10 اقتباسات

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 اقتباسات

Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials. Systematic Review

Clinical nutrition ESPEN 2021 39 اقتباسات

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function. Other

Advances in nutrition … 2021 34 اقتباسات

Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. CCT

Nutrition research (New … 2020 42 اقتباسات

Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. RCT

Gut 2019 148 اقتباسات

Glutamine and the regulation of intestinal permeability: from bench to bedside. Review

Current opinion in … 2017 71 اقتباسات

Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome. Other

JPEN. Journal of … 2016 44 اقتباسات

Glutamine for induction of remission in Crohn's disease. Systematic Review

The Cochrane database … 2016 37 اقتباسات

Intestinal permeability in patients with diarrhea-predominant irritable bowel syndrome: is there a place for glutamine supplementation? Other

Gastroenterology 2015 17 اقتباسات

The role of total parenteral nutrition in inflammatory bowel disease: current aspects. Review

Scandinavian journal of … 2014 56 اقتباسات

Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial. RCT

Digestive diseases and … 2012 81 اقتباسات

Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model. Other

Clinical nutrition (Edinburgh, … 2011 12 اقتباسات

MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Other

Gut 2010 263 اقتباسات

Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine. Review

Clinics (Sao Paulo, … 2010 47 اقتباسات

Behavioral and complementary approaches for the treatment of irritable bowel syndrome. Review

Nutrition in clinical … 2008 42 اقتباسات

Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. RCT

Clinical nutrition (Edinburgh, … 2005 43 اقتباسات

Glutamine supplementation and intestinal permeability in Crohn's disease. RCT

JPEN. Journal of … 2000 18 اقتباسات

Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. RCT

JPEN. Journal of … 1999 129 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 5-15 g/day
ibsdsupport:: 5 g three times daily (15 g/day total)
postexercisegut:: 0.25-0.9 g/kg before intense exercise
gutbarriersupport:: 0.5 g/kg/day (approximately 30-40 g/day for adults)

الحد الأعلى: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
5 g/d	4 weeks	Positive	43
5 g	8.0 weeks	Positive	--
None	--	Mixed	--

أفضل وقت للتناول: Between meals or before exercise; divide doses throughout the day

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Mild gastrointestinal discomfort at high doses
⚠ Headache
⚠ Dizziness at very high doses
⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)

التفاعلات المعروفة

● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)

الحد الأقصى المسموح به: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does L-Glutamine help with Increased Intestinal Permeability (Leaky Gut)?

Based on 2 studies with 80 participants, there is preliminary evidence that needs more research that L-Glutamine may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is D (Very Early Research).

How much L-Glutamine should I take for Increased Intestinal Permeability (Leaky Gut)?

Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Glutamine?

Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Glutamine and Increased Intestinal Permeability (Leaky Gut)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 80 total participants. The overall direction of effect is positive.

مكونات أخرى لـ Increased Intestinal Permeability (Leaky Gut)

Bovine Colostrum B Resistant Starch C Vitamin A C Zinc Carnosine C

L-Glutamine لحالات أخرى

Crohn's Disease C Irritable Bowel Syndrome (IBS) C

References

[1] Ayah Matar et al.. Nutrients. 2024. Intestinal Barrier Impairment, Preservation, and Repair: An Update. doi:10.3390/nu16203494 PubMed
[2] Mengxue He et al.. Cannabis Cannabinoid Res. 2024. Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. doi:10.1089/can.2022.0331 PubMed
[3] Ludovic D Langlois et al.. Int J Mol Sci. 2023. Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. doi:10.3390/ijms24087220 PubMed
[4] Juliana Soares Severo et al.. Clin Nutr ESPEN. 2021. Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials. doi:10.1016/j.clnesp.2020.12.023 PubMed
[5] Mark F McCarty et al.. Adv Nutr. 2021. Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function. doi:10.1093/advances/nmaa139 PubMed
[6] Karin Ried et al.. Nutr Res. 2020. Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. doi:10.1016/j.nutres.2020.02.008 PubMed
[7] QiQi Zhou et al.. Gut. 2019. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. doi:10.1136/gutjnl-2017-315136 PubMed
[8] Najate Achamrah et al.. Curr Opin Clin Nutr Metab Care. 2017. Glutamine and the regulation of intestinal permeability: from bench to bedside. doi:10.1097/MCO.0000000000000339 PubMed
[9] Julien Bertrand et al.. JPEN J Parenter Enteral Nutr. 2016. Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome. doi:10.1177/0148607115587330 PubMed
[10] Anthony K Akobeng et al.. Cochrane Database Syst Rev. 2016. Glutamine for induction of remission in Crohn's disease. doi:10.1002/14651858.CD007348.pub2 PubMed
[11] Moïse Coëffier et al.. Gastroenterology. 2015. Intestinal permeability in patients with diarrhea-predominant irritable bowel syndrome: is there a place for glutamine supplementation? doi:10.1053/j.gastro.2015.02.057 PubMed
[12] John K Triantafillidis et al.. Scand J Gastroenterol. 2014. The role of total parenteral nutrition in inflammatory bowel disease: current aspects. doi:10.3109/00365521.2013.860557 PubMed
[13] Jaya Benjamin et al.. Dig Dis Sci. 2012. Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial. doi:10.1007/s10620-011-1947-9 PubMed
[14] Khaly Mbodji et al.. Clin Nutr. 2011. Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model. doi:10.1016/j.clnu.2011.04.002 PubMed
[15] QiQi Zhou et al.. Gut. 2010. MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. doi:10.1136/gut.2009.181834 PubMed
[16] Jean Robert Rapin et al.. Clinics (Sao Paulo). 2010. Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine. doi:10.1590/S1807-59322010000600012 PubMed
[17] Arnold Wald et al.. Nutr Clin Pract. 2008. Behavioral and complementary approaches for the treatment of irritable bowel syndrome. doi:10.1177/0884533608318677 PubMed
[18] Jeong Wook Kim et al.. Clin Nutr. 2005. Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. doi:10.1016/j.clnu.2005.04.004 PubMed
[19] A K Akobeng et al.. JPEN J Parenter Enteral Nutr. 2000. Glutamine supplementation and intestinal permeability in Crohn's disease. doi:10.1177/0148607100024003196 PubMed
[20] E Den Hond et al.. JPEN J Parenter Enteral Nutr. 1999. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. doi:10.1177/014860719902300107 PubMed

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