Vitamin D 用于 Irritable Bowel Syndrome (IBS)
CLimited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.
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C
结论
Limited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.
Key Study Findings
Review
Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future …
Dose: None
vs: None
Outcome: IBS symptom improvement with vitamin D supplementation
效果: None
None
研究人群: individuals with irritable bowel syndrome
Systematic Review
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews …
Dose: None
vs: Various
Outcome: IBS symptom improvement
效果: Probiotics abdominal pain RR 4.04 (2.36-6.92)
None
研究人群: Adult IBS patients
Meta-Analysis
Double-blind
The effects of vitamin D intake and status on symptom severity and quality-of-life in adults …
Dose: 3,000 IU daily to 50,000 IU bi-weekly
vs: Placebo
Outcome: IBS symptom severity and quality of life
效果: MD 20.33 ng/mL [12.91, 27.74] for 25(OH)D; QoL 3.1
None
研究人群: Adults with IBS and deficient/insufficient vitamin D
Review
Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review.
Dose: None
vs: None
Outcome: Risk of developing Parkinson's disease
效果: None
None
研究人群: General population (narrative review of PD risk factors)
Review
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Dose: None
vs: None
Outcome: Micronutrient deficiency management in pediatric IBD
效果: None
None
研究人群: Children with inflammatory bowel disease (review)
Review
Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.
Dose: None
vs: None
Outcome: IBS symptom relief and pathophysiology modulation
效果: None
None
研究人群: Patients with irritable bowel syndrome (review)
Key Statistics
3
研究数量
400
受试者
↑
Positive
C
等级
Referenced Papers
Gastroenterology nursing : …
None
4 次引用
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical …
Systematic Review
Nutrition reviews
2025
10 次引用
Nutrients
2025
7 次引用
Arquivos de neuro-psiquiatria
2025
6 次引用
Critical reviews in …
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6 次引用
Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.
Review
Nutrients
2025
4 次引用
Nutrients
2025
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Heliyon
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Nutrition and health
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Exploring the Role of Vitamin D and the Gut Microbiome: A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and …
Systematic Review
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3 次引用
Irritable bowel syndrome and endometriosis: diagnosis, similarities, and nutritional management.
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Vitamin D supplementation for irritable bowel syndrome: A systematic review and meta-analysis.
Meta-Analysis
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30 次引用
Association between irritable bowel syndrome and micronutrients: A systematic review.
Systematic Review
Journal of gastroenterology …
2022
29 次引用
The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis.
Meta-Analysis
Nutrition journal
2022
28 次引用
The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome …
Meta-Analysis
Nutrients
2022
24 次引用
PloS one
2022
10 次引用
Nutricion hospitalaria
2022
9 次引用
Association between Serum Vitamin D and Irritable Bowel Syndrome Symptoms in a Sample of Adults.
Other
Nutrients
2022
7 次引用
Journal of gastroenterology …
2022
4 次引用
Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review.
Systematic Review
Nutrients
2021
16 次引用
Vitamin D receptor is overexpressed in the duodenum of patients with irritable bowel syndrome.
Other
Journal of gastroenterology …
2021
10 次引用
Zhongguo dang dai …
2021
The journal of …
2020
294 次引用
The association between irritable bowel syndrome and osteoporosis: a systematic review and meta-analysis.
Meta-Analysis
Osteoporosis international : …
2020
14 次引用
Cureus
2020
10 次引用
Irritable bowel syndrome: a review of the general aspects and the potential role of vitamin D.
Review
Expert review of …
2019
33 次引用
Medicine
2019
4 次引用
Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what …
Systematic Review
European journal of …
2018
39 次引用
Saudi journal of …
2018
38 次引用
The Australian and …
2017
280 次引用
Current gastroenterology reports
2017
157 次引用
PloS one
2017
38 次引用
PloS one
2017
5 次引用
World journal of …
2016
238 次引用
Nutrients
2016
55 次引用
Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?
Review
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2016
41 次引用
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2016
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2015
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2015
56 次引用
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
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2014
38 次引用
European journal of …
2012
225 次引用
Inflammatory bowel diseases
2012
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Meta-Analysis
The Cochrane database …
2012
130 次引用
Current opinion in …
2011
23 次引用
Acta psychiatrica Scandinavica
1979
22 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 600-800 IU/day (RDA)
- ibdsupport:
- 1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
- deficiencycorrection:
- 50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance
上限： 4,000 IU/day (100 mcg); higher doses under medical supervision only
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 3,000 IU daily to 50,000 IU bi-weekly | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 240 |
最佳服用时间： With a meal containing fat for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
- ⚠ Kidney stones with excessive long-term supplementation
- ⚠ Constipation
- ⚠ Metallic taste
已知相互作用
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
可耐受最高摄入量： 4,000 IU/day (100 mcg); higher doses under medical supervision only
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Vitamin D help with Irritable Bowel Syndrome (IBS)?
Based on 3 studies with 400 participants, there is limited but promising evidence that Vitamin D may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).
How much Vitamin D should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion), Kidney stones with excessive long-term supplementation, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Irritable Bowel Syndrome (IBS)
Vitamin D 用于其他健康状况
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