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GutCited

Vitamin D
Vitamin D

vitamin

别名: Cholecalciferol, Vitamin D3, Ergocalciferol, Calciferol

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About





            

                
维生素D通过与肠道上皮细胞上的维生素D受体（VDR）结合，在肠道健康中发挥重要作用，可能有助于增强紧密连接蛋白的表达并支持黏膜免疫反应。维生素D缺乏在炎症性肠病患者中十分常见（发生率高达60%），且与疾病活动度密切相关。研究表明，维生素D补充可能有助于降低溃疡性结肠炎和克罗恩病的复发风险，并支持肠道屏障的整体完整性。维生素D被认为是支持肠道健康的重要营养成分。

            

        

        

        
        
        

            

  
How It Works





            

                
Binds VDR receptors on intestinal epithelial cells enhancing tight junction protein expression (claudin-2, -12, -15); modulates mucosal immune response via regulatory T cell differentiation; induces cathelicidin antimicrobial peptide production in intestinal macrophages; deficiency associated with IBD relapse and increased intestinal permeability.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Inflammatory Bowel Disease (IBD) — General
                                    
                                
                                
                                    B

                                
                                
                                    10
                                
                                
                                    1500
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Irritable Bowel Syndrome (IBS)
                                    
                                
                                
                                    C

                                
                                
                                    3
                                
                                
                                    400
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
                
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                    Kidney stones with excessive long-term supplementation
                
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                    Constipation
                
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                    Metallic taste
                
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Drug & Supplement Interactions





            
    
                
                
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                    Thiazide diuretics (may increase risk of hypercalcemia)
                
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                    Corticosteroids (reduce vitamin D absorption and metabolism)
                
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                    Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
                
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                    Statins (vitamin D may affect statin metabolism)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Vitamin A
                    
                
                
            

        

        
    


    
    












    

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