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Vitamin D für Irritable Bowel Syndrome (IBS)

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Limited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.

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Fazit

Limited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.

Key Study Findings

Review
Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future …
Dose: None vs.: None Outcome: IBS symptom improvement with vitamin D supplementation Wirkung: None None

Population: individuals with irritable bowel syndrome

Systematic Review
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews …
Dose: None vs.: Various Outcome: IBS symptom improvement Wirkung: Probiotics abdominal pain RR 4.04 (2.36-6.92) None

Population: Adult IBS patients

Meta-Analysis Double-blind
The effects of vitamin D intake and status on symptom severity and quality-of-life in adults …
Dose: 3,000 IU daily to 50,000 IU bi-weekly vs.: Placebo Outcome: IBS symptom severity and quality of life Wirkung: MD 20.33 ng/mL [12.91, 27.74] for 25(OH)D; QoL 3.1 None

Population: Adults with IBS and deficient/insufficient vitamin D

Review
Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review.
Dose: None vs.: None Outcome: Risk of developing Parkinson's disease Wirkung: None None

Population: General population (narrative review of PD risk factors)

Review
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Dose: None vs.: None Outcome: Micronutrient deficiency management in pediatric IBD Wirkung: None None

Population: Children with inflammatory bowel disease (review)

Review
Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.
Dose: None vs.: None Outcome: IBS symptom relief and pathophysiology modulation Wirkung: None None

Population: Patients with irritable bowel syndrome (review)

Key Statistics

3

Studien

400

Teilnehmer

Positive

C

Bewertung

Referenced Papers

Scandinavian journal of … 2025
Journal of gastroenterology … 2023 16 Zitierungen
World journal of … 2023 9 Zitierungen
Journal of gastroenterology … 2022 30 Zitierungen
Journal of gastroenterology … 2022 29 Zitierungen
The journal of … 2020 294 Zitierungen
Current gastroenterology reports 2017 157 Zitierungen
World journal of … 2016 238 Zitierungen
Clinics in dermatology 2016 19 Zitierungen
World journal of … 2015 62 Zitierungen
European journal of … 2012 225 Zitierungen
Inflammatory bowel diseases 2012 224 Zitierungen
The Cochrane database … 2012 130 Zitierungen
Current opinion in … 2011 23 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:
600-800 IU/day (RDA)
ibdsupport:
1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
deficiencycorrection:
50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance

Obergrenze: 4,000 IU/day (100 mcg); higher doses under medical supervision only

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
None -- Positive --
None -- Positive --
3,000 IU daily to 50,000 IU bi-weekly -- Positive --
None -- Mixed --
None -- Neutral --
None -- Positive --
None -- Positive --
None -- Positive 240

Beste Einnahmezeit: With a meal containing fat for better absorption

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
  • Kidney stones with excessive long-term supplementation
  • Constipation
  • Metallic taste

Bekannte Wechselwirkungen

  • Thiazide diuretics (may increase risk of hypercalcemia)
  • Corticosteroids (reduce vitamin D absorption and metabolism)
  • Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
  • Statins (vitamin D may affect statin metabolism)

Tolerierbare Höchstaufnahmemenge: 4,000 IU/day (100 mcg); higher doses under medical supervision only

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Vitamin D help with Irritable Bowel Syndrome (IBS)?
Based on 3 studies with 400 participants, there is limited but promising evidence that Vitamin D may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).
How much Vitamin D should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion), Kidney stones with excessive long-term supplementation, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

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