Partially Hydrolyzed Guar Gum (PHGG) 用于 肠易激综合征（IBS）
B 证据 至少一项随机试验支持这一结论，结果基本一致。同时减轻IBS-C和IBS-D症状。是一种耐受性良好、不引起过多气体的益生元。对SIBO相关症状也显示出前景。
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B
结论
同时减轻IBS-C和IBS-D症状。是一种耐受性良好、不引起过多气体的益生元。对SIBO相关症状也显示出前景。
Key Study Findings
Randomized Controlled Trial
n=47
8 weeks
Double-blind
Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and …
Dose: None
vs: Placebo (Group I) and partial formulation (Group II)
Outcome: IBS quality of life (QoL questionnaire)
效果: Dysphoria: median diff -5 (Group III) vs -1 (contr
0.0021 (dysphoria Group III)
研究人群: Patients with IBS
Controlled Clinical Trial
Changes in intestinal microbiota and biochemical parameters in patients with inflammatory bowel disease and irritable …
Dose: Partially hydrolyzed guar gum (PHGG)
vs: Drug therapy alone
Outcome: Gut bacteria ratios and inflammatory markers
效果: None
None
研究人群: Patients with IBD or IBS on drug therapy
Controlled Clinical Trial
12.9 weeks
Role of Baseline Gut Microbiota on Response to Fiber Intervention in Individuals with Irritable Bowel …
Dose: None
vs: baseline
Outcome: IBS symptom improvement
效果: None
None
研究人群: Ibs undertook a 90-day intervention and follow-up
Case Reports
Fibers in pediatric functional gastrointestinal disorders. Practical considerations from clinical cases.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Randomized Controlled Trial
13.0 weeks
Double-blind
Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: …
Dose: None
vs: Placebo
Outcome: Bowel function
效果: None
p=0.05
研究人群: healthy volunteers
Randomized Controlled Trial
12 weeks
Randomized clinical study: Partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients …
Dose: partially hydrolyzed guar gum (PHGG) 5g/day
vs: placebo
Outcome: IBS-SSS and bloating severity
效果: significant improvement in overall IBS-SSS
<0.05
研究人群: Adults with IBS
Key Statistics
5
研究数量
350
受试者
↑
Positive
B
等级
Referenced Papers
Frontiers in nutrition
2025
3 次引用
The journal of …
2024
2 次引用
Nutrients
2023
3 次引用
Fibers in pediatric functional gastrointestinal disorders. Practical considerations from clinical cases.
Case Report
Expert review of …
2021
7 次引用
Nutrients
2019
68 次引用
Nutrition & metabolism
2016
61 次引用
Probiotics for Irritable Bowel Syndrome: Clinical Data in Children.
Systematic Review
Journal of pediatric …
2016
19 次引用
Saudi journal of …
2015
32 次引用
World journal of …
2013
69 次引用
Minerva gastroenterologica e …
2013
Nutrition (Burbank, Los …
2006
119 次引用
Digestive diseases and …
2005
55 次引用
Nutrition (Burbank, Los …
2003
143 次引用
Digestive diseases and …
2002
117 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 5-7 g/day
- ibssupport:
- 5 g/day for 4-12 weeks
- siboadjunct:
- 5 g/day alongside antimicrobial therapy
上限： Well-tolerated up to 36 g/day in clinical trials
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | 8 weeks | Positive | 47 |
| Partially hydrolyzed guar gum (PHGG) | -- | Positive | -- |
| None | 12.9 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | 13.0 weeks | Mixed | -- |
| partially hydrolyzed guar gum (PHGG) 5g/day | 12 weeks | Positive | -- |
| various probiotic strains | -- | Mixed | -- |
| None | 4.0 weeks | Positive | -- |
最佳服用时间： Mixed into food or beverages; dissolves completely without altering texture
Safety & Side Effects
已报告的副作用
- ⚠ Minimal gas and bloating (significantly less than other fibers)
- ⚠ Mild abdominal discomfort in rare cases
- ⚠ Loose stools at very high doses
已知相互作用
- ● May slow absorption of some medications (space 1-2 hours)
- ● Diabetes medications (may modestly affect blood glucose)
可耐受最高摄入量： Well-tolerated up to 36 g/day in clinical trials
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Partially Hydrolyzed Guar Gum (PHGG) help with 肠易激综合征（IBS）?
Based on 5 studies with 350 participants, there is moderate evidence from clinical studies that Partially Hydrolyzed Guar Gum (PHGG) may support 肠易激综合征（IBS） management. Our evidence grade is B (Good Evidence).
How much Partially Hydrolyzed Guar Gum (PHGG) should I take for 肠易激综合征（IBS）?
Studies have used various dosages. A commonly studied range is 5-7 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Partially Hydrolyzed Guar Gum (PHGG)?
Reported side effects may include Minimal gas and bloating (significantly less than other fibers), Mild abdominal discomfort in rare cases, Loose stools at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Partially Hydrolyzed Guar Gum (PHGG) and 肠易激综合征（IBS）?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 肠易激综合征（IBS）
Partially Hydrolyzed Guar Gum (PHGG) 用于其他健康状况
References
- [1] Adrianna Wierzbicka et al.. Front Nutr. 2025. Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and gut health markers in patients … doi:10.3389/fnut.2025.1603011 PubMed
- [2] Hideo Watanabe et al.. J Med Invest. 2024. Changes in intestinal microbiota and biochemical parameters in patients with inflammatory bowel disease and irritable bowel syndrome induced by the … doi:10.2152/jmi.71.121 PubMed
- [3] Jerry Zhou et al.. Nutrients. 2023. Role of Baseline Gut Microbiota on Response to Fiber Intervention in Individuals with Irritable Bowel Syndrome. doi:10.3390/nu15224786 PubMed
- [4] Claudio Romano et al.. Expert Rev Gastroenterol Hepatol. 2021. Fibers in pediatric functional gastrointestinal disorders. Practical considerations from clinical cases. doi:10.1080/17474124.2021.1884543 PubMed
- [5] Zenta Yasukawa et al.. Nutrients. 2019. Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and … doi:10.3390/nu11092170 PubMed
- [6] E Niv et al.. Nutr Metab (Lond). 2016. Randomized clinical study: Partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients with irritable bowel syndrome. doi:10.1186/s12986-016-0070-5 PubMed
- [7] Eleonora Giannetti et al.. J Pediatr Gastroenterol Nutr. 2016. Probiotics for Irritable Bowel Syndrome: Clinical Data in Children. doi:10.1097/MPG.0000000000001220 PubMed
- [8] Luigi Russo et al.. Saudi J Gastroenterol. 2015. Partially hydrolyzed guar gum in the treatment of irritable bowel syndrome with constipation: effects of gender, age, and body mass … doi:10.4103/1319-3767.153835 PubMed
- [9] Claudio Romano et al.. World J Gastroenterol. 2013. Partially hydrolyzed guar gum in pediatric functional abdominal pain. doi:10.3748/wjg.v19.i2.235 PubMed
- [10] G Quartarone. Minerva Gastroenterol Dietol. 2013. Role of PHGG as a dietary fiber: a review article. PubMed
- [11] Edoardo G Giannini et al.. Nutrition. 2006. Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome. doi:10.1016/j.nut.2005.10.003 PubMed
- [12] Giancarlo Parisi et al.. Dig Dis Sci. 2005. Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A … doi:10.1007/s10620-005-2713-7 PubMed
- [13] Joanne L Slavin et al.. Nutrition. 2003. Partially hydrolyzed guar gum: clinical nutrition uses. doi:10.1016/s0899-9007(02)01032-8 PubMed
- [14] G C Parisi et al.. Dig Dis Sci. 2002. High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet … doi:10.1023/a:1016419906546 PubMed
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