循证 补充剂评测
Every gut claim cited.
We read the gut health studies so you don't have to.
Evidence-based supplement research you can trust. We analyze peer-reviewed clinical studies from PubMed and grade every supplement ingredient on a transparent A–D scale. No sponsored rankings, no manufacturer influence — just science.
Featured Ingredients
Lactobacillus rhamnosus GG
probiotic_strainEnhances gut barrier function by upregulating tight junction proteins (claudin-1, occludin, ZO-1) and modulates intestinal immune response via Toll-like receptor …
Lactobacillus plantarum
probiotic_strainAdheres strongly to intestinal mucosa competing with pathogens for binding sites; produces plantaricin antimicrobial peptides with broad-spectrum activity; modulates NF-kB …
Partially Hydrolyzed Guar Gum (PHGG)
fiberWater-soluble non-gelling fiber fermented to butyrate in the colon; normalizes both constipation and diarrhea (bidirectional regulatory effect); supports Bifidobacterium and …
Bifidobacterium lactis
probiotic_strainModulates intestinal immune response via NK cell activation and enhanced phagocytic activity; improves colonic transit time in a dose-dependent manner; …
Vitamin D
vitaminBinds VDR receptors on intestinal epithelial cells enhancing tight junction protein expression (claudin-2, -12, -15); modulates mucosal immune response via …
Zinc
mineralEssential cofactor for intestinal alkaline phosphatase detoxifying bacterial endotoxin (LPS); maintains tight junction integrity via claudin and occludin expression; supports …
Top Conditions
乳糖不耐受
65-70% of global population (varies widely by ethnicity: 5% Northern European to 90% East Asian)
克罗恩病
~0.3% in Western countries; peak onset 15-35 years
功能性消化不良
10-20% of the general population
小肠细菌过度生长（SIBO）
Estimated 6-15% in healthy population; up to 80% in IBS patients
幽门螺杆菌感染
~50% of global population infected; higher in developing countries
急性腹泻
1.7 billion cases of childhood diarrhea globally per year; 525,000 deaths
Recent Evidence Updates
Popular Comparisons
Latest Research
Front Immunol · 2019
Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases.
Am J Clin Nutr · 1991
Omega-3 fatty acids in health and disease and in growth and development.
J Am Coll Nutr · 2002
Omega-3 fatty acids in inflammation and autoimmune diseases.
AAPS J · 2013
Therapeutic roles of curcumin: lessons learned from clinical trials.
Proc Natl Acad Sci … · 2014
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.
Gut · 2014
A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis.
Guides & Resources
管理压力相关肠道问题：消化健康中的身心联系
The intimate connection between psychological stress and digestive symptoms is a common lived experience — the butterflies before a presentation, the loss of appetite during …
lifestyle饮食与肠道健康：循证营养策略
Diet is widely recognized as one of the most powerful modulators of the gut microbiome, with research demonstrating that dietary changes can alter microbial composition …
safety消化酶补充剂：种类、用药时机与安全使用
Digestive enzymes are proteins produced naturally by the body to break down food into absorbable nutrients. The major categories include proteases that break down proteins, …
Evidence Grading System
Every supplement claim on this site is graded on an A–D scale based on peer-reviewed clinical research from PubMed. Our algorithm evaluates study design (RCTs rank highest), consistency of results, sample sizes, and the overall body of evidence. No manufacturer sponsorship influences our grades.
Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.
At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.
Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.
In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.
How It Works
无广告。无赞助排名。只有科学。
研究中心
我们在 PubMed 上检索每一项关于补充剂成分的临床研究。
提取
我们提取关键发现——样本量、研究类型和结果。
A 至 F 级
我们像成绩单一样对证据进行分级——从 A（有力）到 F（阴性）。
明确答案
几秒内获得明确答案——这种补充剂是否真的有效？
Cited Health Network
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FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。