Vitamin D 用于 炎症性肠病(IBD)——概述
B 证据 至少一项随机试验支持这一结论,结果基本一致。补充(1,000至4,000国际单位/日)可降低UC和克罗恩病的复发风险。IBD患者中缺乏很常见(高达60%),且与疾病严重程度相关。
结论
补充(1,000至4,000国际单位/日)可降低UC和克罗恩病的复发风险。IBD患者中缺乏很常见(高达60%),且与疾病严重程度相关。
Key Study Findings
研究人群: individuals with irritable bowel syndrome
研究人群: patients with ulcerative colitis
研究人群: review of probiotics as therapeutic strategy for inflammatory bowel disease
研究人群: Children with inflammatory bowel disease (review)
研究人群: Greek IBD patients (122 CD, 71 UC)
研究人群: Adults with osteoporosis
Key Statistics
10
研究数量
1500
受试者
Positive
等级
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 600-800 IU/day (RDA)
- ibdsupport:
- 1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
- deficiencycorrection:
- 50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance
上限: 4,000 IU/day (100 mcg); higher doses under medical supervision only
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Negative | 193 |
| None | -- | Mixed | -- |
| None | 690 weeks | Neutral | 357656 |
| None | -- | Positive | 310 |
最佳服用时间: With a meal containing fat for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
- ⚠ Kidney stones with excessive long-term supplementation
- ⚠ Constipation
- ⚠ Metallic taste
已知相互作用
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
可耐受最高摄入量: 4,000 IU/day (100 mcg); higher doses under medical supervision only
在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Vitamin D help with 炎症性肠病(IBD)——概述?
How much Vitamin D should I take for 炎症性肠病(IBD)——概述?
Are there side effects of Vitamin D?
How strong is the evidence for Vitamin D and 炎症性肠病(IBD)——概述?
Related Evidence
其他成分用于 炎症性肠病(IBD)——概述
Vitamin D 用于其他健康状况
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