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Vitamin D 用于 炎症性肠病(IBD)——概述

B 证据 至少一项随机试验支持这一结论,结果基本一致。

补充(1,000至4,000国际单位/日)可降低UC和克罗恩病的复发风险。IBD患者中缺乏很常见(高达60%),且与疾病严重程度相关。

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B

结论

补充(1,000至4,000国际单位/日)可降低UC和克罗恩病的复发风险。IBD患者中缺乏很常见(高达60%),且与疾病严重程度相关。

Key Study Findings

Review
Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future …
Dose: None vs: None Outcome: IBS symptom improvement with vitamin D supplementation 效果: None None

研究人群: individuals with irritable bowel syndrome

Review
Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment.
Dose: None vs: None Outcome: None 效果: None None

研究人群: patients with ulcerative colitis

Review
Probiotics in inflammatory bowel disease: microbial modulation and therapeutic prospects.
Dose: None vs: None Outcome: None 效果: None None

研究人群: review of probiotics as therapeutic strategy for inflammatory bowel disease

Review
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Dose: None vs: None Outcome: Micronutrient deficiency management in pediatric IBD 效果: None None

研究人群: Children with inflammatory bowel disease (review)

Observational Study n=193
The importance of vitamin D levels in patients with inflammatory bowel disease.
Dose: None vs: Clinical activity groups and VD status groups Outcome: Vitamin D levels and IBD activity markers 效果: None 0.009 (CD), 0.033 (UC), 0.032

研究人群: Greek IBD patients (122 CD, 71 UC)

Review
Osteoporosis: A Review.
Dose: None vs: None Outcome: None 效果: None None

研究人群: Adults with osteoporosis

Key Statistics

10

研究数量

1500

受试者

↑

Positive

B

等级

Referenced Papers

JAMA 2025
Swiss medical weekly 2024 9 次引用
Nutricion hospitalaria 2024 2 次引用
Paediatrics and international … 2023 48 次引用
Archives of Iranian … 2023 2 次引用
The Cochrane database … 2023 1 次引用
Endocrine connections 2022 50 次引用
Journal of inflammation … 2022 50 次引用
Autoimmunity reviews 2022 44 次引用
Frontiers in bioscience … 2022 17 次引用
European journal of … 2021 40 次引用
Autoimmunity reviews 2020 48 次引用
Acta biochimica Polonica 2020 10 次引用
The Korean journal … 2020 3 次引用
Revista espanola de … 2020 2 次引用
Frontline gastroenterology 2019 58 次引用
Critical reviews in … 2019 45 次引用
Complementary therapies in … 2019 27 次引用
Current opinion in … 2019 5 次引用
Current opinion in … 2018 94 次引用
Gastroenterology clinics of … 2018 67 次引用
Journal of research … 2018 48 次引用
Gastroenterology 2017 335 次引用
Nutrition in clinical … 2017 55 次引用
World journal of … 2016 238 次引用
Current gastroenterology reports 2016 22 次引用
Journal of medicinal … 2016 17 次引用
Gastroenterology & hepatology 2016 7 次引用
BioMed research international 2015 149 次引用
World journal of … 2015 62 次引用
Healthcare (Basel, Switzerland) 2015 7 次引用
Journal of inflammation … 2014 411 次引用
Experimental biology and … 2014 131 次引用
Inflammatory bowel diseases 2012 224 次引用
Vitamins and hormones 2011 25 次引用
Current opinion in … 2011 23 次引用
Joint bone spine 2010 281 次引用
Acta medica Indonesiana 2007 4 次引用
Nature clinical practice. … 2005 191 次引用
Alimentary pharmacology & … 2003 179 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:
600-800 IU/day (RDA)
ibdsupport:
1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
deficiencycorrection:
50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance

上限: 4,000 IU/day (100 mcg); higher doses under medical supervision only

研究中使用的剂量

剂量 持续时间 效果 N
None -- Positive --
None -- Mixed --
None -- Positive --
None -- Neutral --
None -- Negative 193
None -- Mixed --
None 690 weeks Neutral 357656
None -- Positive 310

最佳服用时间: With a meal containing fat for better absorption

Safety & Side Effects

已报告的副作用

  • ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
  • ⚠ Kidney stones with excessive long-term supplementation
  • ⚠ Constipation
  • ⚠ Metallic taste

已知相互作用

  • ● Thiazide diuretics (may increase risk of hypercalcemia)
  • ● Corticosteroids (reduce vitamin D absorption and metabolism)
  • ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
  • ● Statins (vitamin D may affect statin metabolism)

可耐受最高摄入量: 4,000 IU/day (100 mcg); higher doses under medical supervision only

在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Vitamin D help with 炎症性肠病(IBD)——概述?
Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Vitamin D may support 炎症性肠病(IBD)——概述 management. Our evidence grade is B (Good Evidence).
How much Vitamin D should I take for 炎症性肠病(IBD)——概述?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion), Kidney stones with excessive long-term supplementation, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and 炎症性肠病(IBD)——概述?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

其他成分用于 炎症性肠病(IBD)——概述

Vitamin D 用于其他健康状况

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