Vitamin D 用于 Inflammatory Bowel Disease (IBD) — General
BSupplementation (1,000-4,000 IU/day) reduces relapse risk in both UC and Crohn's. Deficiency is common in IBD (up to 60%) and correlates with disease severity.
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B
结论
Supplementation (1,000-4,000 IU/day) reduces relapse risk in both UC and Crohn's. Deficiency is common in IBD (up to 60%) and correlates with disease severity.
Key Study Findings
Review
Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future …
Dose: None
vs: None
Outcome: IBS symptom improvement with vitamin D supplementation
效果: None
None
研究人群: individuals with irritable bowel syndrome
Review
Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: patients with ulcerative colitis
Review
Probiotics in inflammatory bowel disease: microbial modulation and therapeutic prospects.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: review of probiotics as therapeutic strategy for inflammatory bowel disease
Review
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Dose: None
vs: None
Outcome: Micronutrient deficiency management in pediatric IBD
效果: None
None
研究人群: Children with inflammatory bowel disease (review)
Observational Study
n=193
The importance of vitamin D levels in patients with inflammatory bowel disease.
Dose: None
vs: Clinical activity groups and VD status groups
Outcome: Vitamin D levels and IBD activity markers
效果: None
0.009 (CD), 0.033 (UC), 0.032
研究人群: Greek IBD patients (122 CD, 71 UC)
Review
Osteoporosis: A Review.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Adults with osteoporosis
Key Statistics
10
研究数量
1500
受试者
↑
Positive
B
等级
Referenced Papers
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CCL20 expression is elevated in inflammatory bowel disease and attenuated by vitamin D metabolites.
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2020
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2020
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2018
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48 次引用
Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what …
Systematic Review
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2018
39 次引用
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2017
335 次引用
Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.
Meta-Analysis
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2017
73 次引用
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2017
55 次引用
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14 次引用
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8 次引用
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2015
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 600-800 IU/day (RDA)
- ibdsupport:
- 1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
- deficiencycorrection:
- 50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance
上限： 4,000 IU/day (100 mcg); higher doses under medical supervision only
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Negative | 193 |
| None | -- | Mixed | -- |
| None | 690 weeks | Neutral | 357656 |
| None | -- | Positive | 310 |
最佳服用时间： With a meal containing fat for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
- ⚠ Kidney stones with excessive long-term supplementation
- ⚠ Constipation
- ⚠ Metallic taste
已知相互作用
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
可耐受最高摄入量： 4,000 IU/day (100 mcg); higher doses under medical supervision only
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Vitamin D help with Inflammatory Bowel Disease (IBD) — General?
Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Vitamin D may support Inflammatory Bowel Disease (IBD) — General management. Our evidence grade is B (Good Evidence).
How much Vitamin D should I take for Inflammatory Bowel Disease (IBD) — General?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion), Kidney stones with excessive long-term supplementation, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Inflammatory Bowel Disease (IBD) — General?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Inflammatory Bowel Disease (IBD) — General
Vitamin D 用于其他健康状况
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