The interaction between obesity and visceral hypersensitivity.

Wu Yanping, Xuefen Gao, Yizun Cheng, Mi Liu, Siyu Liao et al.

Review Journal of gastroenterology and hepatology 2023 16 次引用

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Study Design

研究类型: Review
研究人群: None

干预措施: The interaction between obesity and visceral hypersensitivity. None
对照组: None
主要结局: inflammation markers
效应方向: Mixed
偏倚风险: Unclear

Abstract

Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory mediators, causing intestinal hyperpermeability and nerve endings activation. (ii) Obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon. (iii) Vitamin D deficiency contributes to both fat accumulation and disruption of the intestinal mucosal barrier. (iv) Brain-gut axis may be another bridge from obesity to visceral hypersensitivity.

简要概述

This work has suggested that brain‐gut axis may be another bridge from obesity to visceral hypersensitivity, and obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon.

Used In Evidence Reviews

C Vitamin D 用于 Irritable Bowel Syndrome (IBS)

The interaction between obesity and visceral hypersensitivity.

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Study Design

Abstract

简要概述

Used In Evidence Reviews

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