Lactobacillus rhamnosus GG 用于 肠易激综合征（IBS）
B 证据 至少一项随机试验支持这一结论，结果基本一致。多项RCT显示IBS症状有所改善，尤其是腹胀和腹痛。在IBS-D亚型中效果最强。在所有IBS亚型中结果并不一致。
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B
结论
多项RCT显示IBS症状有所改善，尤其是腹胀和腹痛。在IBS-D亚型中效果最强。在所有IBS亚型中结果并不一致。
Key Study Findings
Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None
vs: placebo
Outcome: improvement in key IBS symptoms
效果: None
None
研究人群: patients with IBS from 32 RCTs evaluating 10 probiotic strains
Randomized Controlled Trial
3 weeks
Double-blind
Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review …
Dose: None
vs: Placebo
Outcome: Pain outcomes
效果: None
None
研究人群: IBS patients
Systematic Review
n=3
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic …
Dose: None
vs: None
Outcome: Abdominal pain frequency/intensity, constipation
效果: None
None
研究人群: Children with FAPD or functional constipation
Systematic Review
Probiotics for Irritable Bowel Syndrome: Clinical Data in Children.
Dose: various probiotic strains
vs: placebo
Outcome: IBS symptom improvement in children
效果: LGG showed benefit in some studies
None
研究人群: Children with IBS
Review
Probiotic Bacterial and Fungal Strains: Claims with Evidence.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Various populations (probiotic claims review)
Review
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: IBD patients
Key Statistics
8
研究数量
1200
受试者
↑
Positive
B
等级
Referenced Papers
Journal of clinical …
2026
Nutrients
2024
5 次引用
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Systematic Review
Journal of clinical …
2018
34 次引用
Digestive diseases (Basel, …
2016
37 次引用
Probiotics for Irritable Bowel Syndrome: Clinical Data in Children.
Systematic Review
Journal of pediatric …
2016
19 次引用
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
Systematic Review
Paediatric drugs
2015
122 次引用
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Review
Nutrition in clinical …
2015
31 次引用
BMC gastroenterology
2010
91 次引用
Alimentary pharmacology & …
2007
102 次引用
Asia Pacific journal …
2006
45 次引用
Asia Pacific journal …
2006
Alimentary pharmacology & …
2005
398 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 10-20 billion CFU/day
- ibssupport:
- 10 billion CFU/day for 4-8 weeks
- aadprevention:
- 10-20 billion CFU/day (start with antibiotic, continue 7 days after)
上限： Generally well-tolerated up to 40 billion CFU/day in clinical trials
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | 3 weeks | Positive | -- |
| None | -- | Mixed | 3 |
| various probiotic strains | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | 26.0 weeks | Mixed | -- |
最佳服用时间： On an empty stomach or 30 minutes before meals for optimal survival
Safety & Side Effects
已报告的副作用
- ⚠ Mild gas and bloating during initial use (usually resolves in 1-2 weeks)
- ⚠ Rare reports of bacteremia in severely immunocompromised individuals
- ⚠ Occasional loose stools during adjustment period
- ⚠ Very rare: systemic infection in critically ill patients with central venous catheters
已知相互作用
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (theoretical risk of infection in immunocompromised patients)
- ● Antifungals (no known interaction but may affect gut flora balance)
可耐受最高摄入量： Generally well-tolerated up to 40 billion CFU/day in clinical trials
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Lactobacillus rhamnosus GG help with 肠易激综合征（IBS）?
Based on 8 studies with 1,200 participants, there is moderate evidence from clinical studies that Lactobacillus rhamnosus GG may support 肠易激综合征（IBS） management. Our evidence grade is B (Good Evidence).
How much Lactobacillus rhamnosus GG should I take for 肠易激综合征（IBS）?
Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus rhamnosus GG?
Reported side effects may include Mild gas and bloating during initial use (usually resolves in 1-2 weeks), Rare reports of bacteremia in severely immunocompromised individuals, Occasional loose stools during adjustment period, Very rare: systemic infection in critically ill patients with central venous catheters. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus rhamnosus GG and 肠易激综合征（IBS）?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 肠易激综合征（IBS）
Lactobacillus rhamnosus GG 用于其他健康状况
References
- [1] Roman Maslennikov et al.. J Clin Med. 2026. Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. doi:10.3390/jcm15031152 PubMed
- [2] Silvia Salvatore et al.. Nutrients. 2024. Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights. doi:10.3390/nu16030349 PubMed
- [3] Carrie A M Wegh et al.. J Clin Gastroenterol. 2018. Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. doi:10.1097/MCG.0000000000001054 PubMed
- [4] Hania Szajewska et al.. Dig Dis. 2016. Probiotic Bacterial and Fungal Strains: Claims with Evidence. doi:10.1159/000443359 PubMed
- [5] Eleonora Giannetti et al.. J Pediatr Gastroenterol Nutr. 2016. Probiotics for Irritable Bowel Syndrome: Clinical Data in Children. doi:10.1097/MPG.0000000000001220 PubMed
- [6] Sylvia Cruchet et al.. Paediatr Drugs. 2015. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. doi:10.1007/s40272-015-0124-6 PubMed
- [7] Danielle Barnes et al.. Nutr Clin Pract. 2015. Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children. doi:10.1177/0884533615610081 PubMed
- [8] Anna Lyra et al.. BMC Gastroenterol. 2010. Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes. doi:10.1186/1471-230X-10-110 PubMed
- [9] K Kajander et al.. Aliment Pharmacol Ther. 2007. Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome. doi:10.1111/j.1365-2036.2007.03391.x PubMed
- [10] Seppo Salminen et al.. Asia Pac J Clin Nutr. 2006. Intestinal colonisation, microbiota and future probiotics? PubMed
- [11] Kajsa Kajander et al.. Asia Pac J Clin Nutr. 2006. Clinical studies on alleviating the symptoms of irritable bowel syndrome. PubMed
- [12] K Kajander et al.. Aliment Pharmacol Ther. 2005. A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. doi:10.1111/j.1365-2036.2005.02579.x PubMed
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