L-Glutamine 用于 Increased Intestinal Permeability (Leaky Gut)
DSmall studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.
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D
结论
Small studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.
Key Study Findings
Review
Intestinal Barrier Impairment, Preservation, and Repair: An Update.
Dose: None
vs: None
Outcome: Intestinal barrier preservation and repair
效果: None
None
研究人群: IBD and IBS patients (review)
Other
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.
Dose: None
vs: None
Outcome: Cholesterol levels
效果: None
None
研究人群: Mouse model
In Vitro
Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …
Dose: None
vs: None
Outcome: inflammation markers
效果: None
None
研究人群: Mice
Other
Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Systematic Review
Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.
Dose: None
vs: Placebo or standard care
Outcome: IBD symptom improvement
效果: None
None
研究人群: IBD patients
Controlled Clinical Trial
n=43
4 weeks
Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with …
Dose: 5 g/d
vs: None
Outcome: None
效果: None
None
研究人群: IBS patients
Key Statistics
2
研究数量
80
受试者
↑
Positive
D
等级
Referenced Papers
Nutrients
2024
47 次引用
Cannabis and cannabinoid …
2024
10 次引用
International journal of …
2023
9 次引用
Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.
Systematic Review
Clinical nutrition ESPEN
2021
39 次引用
Advances in nutrition …
2021
34 次引用
Nutrition research (New …
2020
42 次引用
Gut
2019
148 次引用
Current opinion in …
2017
71 次引用
JPEN. Journal of …
2016
44 次引用
Glutamine for induction of remission in Crohn's disease.
Systematic Review
The Cochrane database …
2016
37 次引用
Gastroenterology
2015
17 次引用
Scandinavian journal of …
2014
56 次引用
Digestive diseases and …
2012
81 次引用
Clinical nutrition (Edinburgh, …
2011
12 次引用
MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome.
Other
Gut
2010
263 次引用
Clinics (Sao Paulo, …
2010
47 次引用
Nutrition in clinical …
2008
42 次引用
Clinical nutrition (Edinburgh, …
2005
43 次引用
JPEN. Journal of …
2000
18 次引用
JPEN. Journal of …
1999
129 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 5-15 g/day
- ibsdsupport:
- 5 g three times daily (15 g/day total)
- postexercisegut:
- 0.25-0.9 g/kg before intense exercise
- gutbarriersupport:
- 0.5 g/kg/day (approximately 30-40 g/day for adults)
上限： Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 5 g/d | 4 weeks | Positive | 43 |
| 5 g | 8.0 weeks | Positive | -- |
| None | -- | Mixed | -- |
最佳服用时间： Between meals or before exercise; divide doses throughout the day
Safety & Side Effects
已报告的副作用
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Headache
- ⚠ Dizziness at very high doses
- ⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)
已知相互作用
- ● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
- ● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
- ● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)
可耐受最高摄入量： Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does L-Glutamine help with Increased Intestinal Permeability (Leaky Gut)?
Based on 2 studies with 80 participants, there is preliminary evidence that needs more research that L-Glutamine may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is D (Very Early Research).
How much L-Glutamine should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Glutamine?
Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Glutamine and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 80 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Increased Intestinal Permeability (Leaky Gut)
L-Glutamine 用于其他健康状况
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