Vitamin A 用于 Increased Intestinal Permeability (Leaky Gut)
CRetinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
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C
结论
Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
Key Study Findings
Observational Study
n=54
Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in …
Dose: None
vs: None
Outcome: Intestinal permeability (lactulose:mannitol ratio)
效果: AOR 0.15 (CI 0.05-0.42) for retinol
<0.001
研究人群: Community-dwelling elderly individuals
Other
12 weeks
Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.
Dose: None
vs: HFD control mice
Outcome: NAFLD biomarkers and gut microbiota composition
效果: None
None
研究人群: HFD-induced NAFLD mouse model
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
vs: None
Outcome: Athletic performance and nutritional optimization
效果: None
None
研究人群: Vegan athletes (narrative review)
Observational Study
Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …
Dose: None
vs: None
Outcome: DALYs and mortality rates of congenital birth defects
效果: DALYs decreased 59.77%, deaths decreased 63.81%
None
研究人群: G20 countries population, 1990-2021
Other
12 weeks
Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and …
Dose: None
vs: None
Outcome: Cognitive function
效果: None
None
研究人群: Mouse model (APP/PS1)
In Vitro
Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress.
Dose: None
vs: None
Outcome: oxidative stress markers
效果: None
p < 0.05
研究人群: Chickens
Key Statistics
3
研究数量
250
受试者
↑
Positive
C
等级
Referenced Papers
BMC pregnancy and …
2025
6 次引用
Current nutrition reports
2025
3 次引用
NPJ science of …
2025
2 次引用
Scientific reports
2025
Frontiers in nutrition
2024
12 次引用
Journal of animal …
2023
11 次引用
Food science & …
2023
2 次引用
International journal of …
2022
60 次引用
Journal of Nippon …
2021
26 次引用
Frontiers in immunology
2021
8 次引用
Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A …
Systematic Review
Psychiatry research
2020
60 次引用
Journal of diabetes …
2020
11 次引用
Blood
2017
49 次引用
ACS chemical neuroscience
2017
20 次引用
World journal of …
2016
238 次引用
Clinics in dermatology
2016
19 次引用
The Journal of …
2015
31 次引用
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Other
Journal of pediatric …
2014
38 次引用
Nutrition and cancer
2014
5 次引用
Blood
2013
54 次引用
European journal of …
2012
225 次引用
Journal of burn …
2012
16 次引用
Medical oncology (Northwood, …
2010
12 次引用
Scandinavian journal of …
2010
6 次引用
Journal of nutritional …
2010
2 次引用
European journal of …
2009
24 次引用
Veterinary parasitology
2008
80 次引用
Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.
Other
American journal of …
2008
25 次引用
European journal of …
2005
2 次引用
Journal of health, …
2003
The British journal …
2002
358 次引用
Rossiiskii fiziologicheskii zhurnal …
2002
Journal of pediatric …
2001
56 次引用
Journal of acquired …
2001
15 次引用
The Pediatric infectious …
2000
14 次引用
Life sciences
1998
35 次引用
Biulleten' eksperimental'noi biologii …
1987
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 700-900 mcg RAE/day (RDA for adults)
- gutbarriersupport:
- 900 mcg RAE/day from mixed sources
- deficiencycorrection:
- 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)
上限： 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Negative | 54 |
| None | 12 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 12 weeks | Negative | -- |
| None | -- | Positive | -- |
| None | 11 weeks | Positive | -- |
| 10 mg/kg | -- | Negative | -- |
最佳服用时间： With meals containing fat for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Hepatotoxicity at chronic high doses of preformed vitamin A
- ⚠ Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
- ⚠ Nausea, headache, and dizziness
- ⚠ Bone density reduction with long-term excess
已知相互作用
- ● Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
- ● Orlistat (reduces absorption of fat-soluble vitamins)
- ● Alcohol (increases hepatotoxicity risk of vitamin A)
- ● Tetracycline antibiotics (increased risk of intracranial pressure)
可耐受最高摄入量： 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Vitamin A help with Increased Intestinal Permeability (Leaky Gut)?
Based on 3 studies with 250 participants, there is limited but promising evidence that Vitamin A may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is C (Some Evidence).
How much Vitamin A should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin A?
Reported side effects may include Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin A and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Increased Intestinal Permeability (Leaky Gut)
Vitamin A 用于其他健康状况
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