Vitamin D cho Inflammatory Bowel Disease (IBD) — General

Supplementation (1,000-4,000 IU/day) reduces relapse risk in both UC and Crohn's. Deficiency is common in IBD (up to 60%) and correlates with disease severity.

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Kết luận

Supplementation (1,000-4,000 IU/day) reduces relapse risk in both UC and Crohn's. Deficiency is common in IBD (up to 60%) and correlates with disease severity.

Key Study Findings

Review

Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future …

Dose: None so với: None Outcome: IBS symptom improvement with vitamin D supplementation Hiệu quả: None None

Đối tượng nghiên cứu: individuals with irritable bowel syndrome

Review

Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment.

Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: patients with ulcerative colitis

Review

Probiotics in inflammatory bowel disease: microbial modulation and therapeutic prospects.

Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: review of probiotics as therapeutic strategy for inflammatory bowel disease

Review

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?

Dose: None so với: None Outcome: Micronutrient deficiency management in pediatric IBD Hiệu quả: None None

Đối tượng nghiên cứu: Children with inflammatory bowel disease (review)

Observational Study n=193

The importance of vitamin D levels in patients with inflammatory bowel disease.

Dose: None so với: Clinical activity groups and VD status groups Outcome: Vitamin D levels and IBD activity markers Hiệu quả: None 0.009 (CD), 0.033 (UC), 0.032

Đối tượng nghiên cứu: Greek IBD patients (122 CD, 71 UC)

Review

Osteoporosis: A Review.

Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: Adults with osteoporosis

Key Statistics

Nghiên cứu

1500

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future Research Opportunities. Other

Gastroenterology nursing : … None 4 trích dẫn

Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment. Review

Digestive diseases and … 2026 1 trích dẫn

Probiotics in inflammatory bowel disease: microbial modulation and therapeutic prospects. Review

Trends in molecular … 2025 35 trích dẫn

Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review. Review

Arquivos de neuro-psiquiatria 2025 6 trích dẫn

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? Review

Nutrients 2025 4 trích dẫn

The importance of vitamin D levels in patients with inflammatory bowel disease. Other

Journal of physiology … 2025 3 trích dẫn

Serum Vitamin D Levels and Long-Term Risk of Elderly-Onset Inflammatory Bowel Disease: A Large-Scale Prospective Cohort Study. Other

The American journal … 2025

CCL20 expression is elevated in inflammatory bowel disease and attenuated by vitamin D metabolites. Other

Scientific reports 2025

Osteoporosis: A Review. Review

JAMA 2025

Intestinal Barrier Impairment, Preservation, and Repair: An Update. Review

Nutrients 2024 47 trích dẫn

Contemporary Perspectives on the Role of Vitamin D in Enhancing Gut Health and Its Implications for Preventing and Managing Intestinal … Review

Nutrients 2024 27 trích dẫn

Bone health in patients with inflammatory bowel disease. Review

Swiss medical weekly 2024 9 trích dẫn

[Role of diet in the prevention and development of Crohn's Disease]. Review

Nutricion hospitalaria 2024 2 trích dẫn

Vitamin D and CRP are associated in hospitalized inflammatory bowel disease (IBD) patients in Shanghai. Other

Asia Pacific journal … 2024 1 trích dẫn

Vitamin D: immune function, inflammation, infections and auto-immunity. Review

Paediatrics and international … 2023 48 trích dẫn

Vitamin D and Microbiome: Molecular Interaction in Inflammatory Bowel Disease Pathogenesis. Review

The American journal … 2023 37 trích dẫn

Vitamin D therapy in pediatric patients with inflammatory bowel disease: a systematic review and meta-analysis. Meta-Analysis

World journal of … 2023 11 trích dẫn

Association between vitamin D level and pediatric inflammatory bowel disease: A systematic review and meta-analysis. Review

Frontiers in pediatrics 2023 6 trích dẫn

Assessing vitamin D as a biomarker in inflammatory bowel disease. Other

JGH open : … 2023 5 trích dẫn

Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model. Other

Toxicology mechanisms and … 2023 5 trích dẫn

Body Composition in Inflammatory Bowel Disease. Review

Archives of Iranian … 2023 2 trích dẫn

Vitamin D for the treatment of inflammatory bowel disease. Systematic Review

The Cochrane database … 2023 1 trích dẫn

Autoimmune disease and interconnections with vitamin D. Review

Endocrine connections 2022 50 trích dẫn

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease. Review

Journal of inflammation … 2022 50 trích dẫn

Molecular basis of vitamin D action in inflammatory bowel disease. Review

Autoimmunity reviews 2022 44 trích dẫn

Vitamin D in Prevention of Autoimmune Diseases. Review

Frontiers in bioscience … 2022 17 trích dẫn

Identification of putative transcriptomic biomarkers in irritable bowel syndrome (IBS): Differential gene expression and regulation of TPH1 and SERT by … Other

PloS one 2022 10 trích dẫn

Vitamin D supplementation in inflammatory bowel disease: a narrative review. Review

Medwave 2022 4 trích dẫn

Diet supporting therapy for inflammatory bowel diseases. Review

European journal of … 2021 40 trích dẫn

Effects of oral vitamin D supplementation on inflammatory bowel disease: a systematic review and meta-analysis. Meta-Analysis

Food & function 2021 25 trích dẫn

Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review. Systematic Review

Nutrients 2021 16 trích dẫn

Vitamin D Therapy in Adults With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Meta-Analysis

Inflammatory bowel diseases 2020 57 trích dẫn

Mucosal vitamin D signaling in inflammatory bowel disease. Review

Autoimmunity reviews 2020 48 trích dẫn

Vitamin D in autoimmune bullous disease. Review

Acta biochimica Polonica 2020 10 trích dẫn

[Inflammatory Bowel Disease and Vitamin D]. Review

The Korean journal … 2020 3 trích dẫn

Vitamin D and inflammatory bowel disease: what do we know so far? Review

Revista espanola de … 2020 2 trích dẫn

The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management. Review

Nutrients 2019 193 trích dẫn

Managing vitamin D deficiency in inflammatory bowel disease. Review

Frontline gastroenterology 2019 58 trích dẫn

Associations between inflammatory bowel diseases and vitamin D. Review

Critical reviews in … 2019 45 trích dẫn

Vitamin D in inflammatory bowel disease: From biology to clinical implications. Review

Complementary therapies in … 2019 27 trích dẫn

Vitamin D in Inflammatory Bowel Disease: Biological, Clinical and Therapeutic Aspects. Review

Current drug metabolism 2019 7 trích dẫn

Nutritional regulators of intestinal inflammation. Review

Current opinion in … 2019 5 trích dẫn

Vitamin D in inflammatory bowel disease: more than just a supplement. Review

Current opinion in … 2018 94 trích dẫn

Nutritional Interventions in the Patient with Inflammatory Bowel Disease. Review

Gastroenterology clinics of … 2018 67 trích dẫn

Vitamin D, the gut microbiome and inflammatory bowel disease. Review

Journal of research … 2018 48 trích dẫn

Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what … Systematic Review

European journal of … 2018 39 trích dẫn

Diet as a Trigger or Therapy for Inflammatory Bowel Diseases. Other

Gastroenterology 2017 335 trích dẫn

Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease: Systematic Review and Meta-Analysis. Meta-Analysis

Journal of clinical … 2017 73 trích dẫn

Role of Vitamin D in Inflammatory Bowel Disease. Review

Nutrition in clinical … 2017 55 trích dẫn

Vitamin D status in pediatric irritable bowel syndrome. Other

PloS one 2017 38 trích dẫn

Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands. Review

Current medicinal chemistry 2017 14 trích dẫn

Vitamin D Levels and Outcomes in Inflammatory Bowel Disease-Which is the Chicken and Which is the Egg? Other

Clinical gastroenterology and … 2017 8 trích dẫn

[Nutrition and dietary supplement in chronic inflammatory bowel diesease]. Review

Ugeskrift for laeger 2017

Diet and nutritional factors in inflammatory bowel diseases. Review

World journal of … 2016 238 trích dẫn

Protective links between vitamin D, inflammatory bowel disease and colon cancer. Review

World journal of … 2016 122 trích dẫn

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 trích dẫn

Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis. Review

Current pharmaceutical design 2016 32 trích dẫn

Vitamin D and the Pathogenesis of Inflammatory Bowel Disease. Review

Current gastroenterology reports 2016 22 trích dẫn

Reflections About Inflammatory Bowel Disease and Vitamins A and D. Review

Journal of medicinal … 2016 17 trích dẫn

Vitamin D and Inflammatory Bowel Disease. Other

Gastroenterology & hepatology 2016 7 trích dẫn

Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis. Meta-Analysis

Inflammatory bowel diseases 2015 214 trích dẫn

Vitamin D and inflammatory bowel disease. Review

BioMed research international 2015 149 trích dẫn

Role of vitamins in gastrointestinal diseases. Review

World journal of … 2015 62 trích dẫn

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn? Review

The Proceedings of … 2015 46 trích dẫn

The Role of Vitamin D in Inflammatory Bowel Disease. Review

Healthcare (Basel, Switzerland) 2015 7 trích dẫn

Vitamin D and inflammatory diseases. Review

Journal of inflammation … 2014 411 trích dẫn

Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease. Review

Experimental biology and … 2014 131 trích dẫn

Vitamin D improves inflammatory bowel disease outcomes: basic science and clinical review. Review

World journal of … 2014 117 trích dẫn

Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. Other

Journal of pediatric … 2014 38 trích dẫn

Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. Review

Inflammatory bowel diseases 2012 224 trích dẫn

Review article: vitamin D and inflammatory bowel disease--established concepts and future directions. Review

Alimentary pharmacology & … 2012 111 trích dẫn

Vitamin D: new roles and therapeutic potential in inflammatory bowel disease. Review

Current drug metabolism 2012 28 trích dẫn

Vitamin D and inflammatory bowel disease. Review

Vitamins and hormones 2011 25 trích dẫn

Nutrition and inflammatory bowel disease: primary or adjuvant therapy. Review

Current opinion in … 2011 23 trích dẫn

Vitamin D and inflammation. Review

Joint bone spine 2010 281 trích dẫn

Vitamin D and autoimmune disease. Review

Acta medica Indonesiana 2007 4 trích dẫn

Mechanisms of disease: vitamin D and inflammatory bowel disease. Review

Nature clinical practice. … 2005 191 trích dẫn

Review article: nutrition and adult inflammatory bowel disease. Review

Alimentary pharmacology & … 2003 179 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 600-800 IU/day (RDA)
ibdsupport:: 1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
deficiencycorrection:: 50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance

Giới hạn trên: 4,000 IU/day (100 mcg); higher doses under medical supervision only

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Positive	--
None	--	Mixed	--
None	--	Positive	--
None	--	Neutral	--
None	--	Negative	193
None	--	Mixed	--
None	690 weeks	Neutral	357656
None	--	Positive	310

Thời điểm dùng tốt nhất: With a meal containing fat for better absorption

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
⚠ Kidney stones with excessive long-term supplementation
⚠ Constipation
⚠ Metallic taste

Tương tác đã biết

● Thiazide diuretics (may increase risk of hypercalcemia)
● Corticosteroids (reduce vitamin D absorption and metabolism)
● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
● Statins (vitamin D may affect statin metabolism)

Mức hấp thụ tối đa cho phép: 4,000 IU/day (100 mcg); higher doses under medical supervision only

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Vitamin D help with Inflammatory Bowel Disease (IBD) — General?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Vitamin D may support Inflammatory Bowel Disease (IBD) — General management. Our evidence grade is B (Good Evidence).

How much Vitamin D should I take for Inflammatory Bowel Disease (IBD) — General?

Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion), Kidney stones with excessive long-term supplementation, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Inflammatory Bowel Disease (IBD) — General?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Related Evidence

Các thành phần khác cho Inflammatory Bowel Disease (IBD) — General

N-Acetyl Cysteine (NAC) D

Vitamin D cho các tình trạng khác

Irritable Bowel Syndrome (IBS) C

Đánh giá nhanh

Supplementation (1,000-4,000 IU/day) reduces relapse risk in both UC and Crohn's. Deficiency is common in IBD (up to 60%) and correlates with disease severity.

Evidence Strength72%

High confidence

Phân tích nghiên cứu

RCT (0)Meta (5)Other (5)

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