Vitamin D pour Inflammatory Bowel Disease (IBD) — General

Supplementation (1,000-4,000 IU/day) reduces relapse risk in both UC and Crohn's. Deficiency is common in IBD (up to 60%) and correlates with disease severity.

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En conclusion

Supplementation (1,000-4,000 IU/day) reduces relapse risk in both UC and Crohn's. Deficiency is common in IBD (up to 60%) and correlates with disease severity.

Key Study Findings

Review

Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future …

Dose: None vs: None Outcome: IBS symptom improvement with vitamin D supplementation Effet: None None

Population: individuals with irritable bowel syndrome

Review

Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment.

Dose: None vs: None Outcome: None Effet: None None

Population: patients with ulcerative colitis

Review

Probiotics in inflammatory bowel disease: microbial modulation and therapeutic prospects.

Dose: None vs: None Outcome: None Effet: None None

Population: review of probiotics as therapeutic strategy for inflammatory bowel disease

Review

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?

Dose: None vs: None Outcome: Micronutrient deficiency management in pediatric IBD Effet: None None

Population: Children with inflammatory bowel disease (review)

Observational Study n=193

The importance of vitamin D levels in patients with inflammatory bowel disease.

Dose: None vs: Clinical activity groups and VD status groups Outcome: Vitamin D levels and IBD activity markers Effet: None 0.009 (CD), 0.033 (UC), 0.032

Population: Greek IBD patients (122 CD, 71 UC)

Review

Osteoporosis: A Review.

Dose: None vs: None Outcome: None Effet: None None

Population: Adults with osteoporosis

Key Statistics

Études

1500

Participants

↑

Positive

Note

Referenced Papers

Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future Research Opportunities. Other

Gastroenterology nursing : … None 4 citations

Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment. Review

Digestive diseases and … 2026 1 citations

Probiotics in inflammatory bowel disease: microbial modulation and therapeutic prospects. Review

Trends in molecular … 2025 35 citations

Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review. Review

Arquivos de neuro-psiquiatria 2025 6 citations

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? Review

Nutrients 2025 4 citations

The importance of vitamin D levels in patients with inflammatory bowel disease. Other

Journal of physiology … 2025 3 citations

Serum Vitamin D Levels and Long-Term Risk of Elderly-Onset Inflammatory Bowel Disease: A Large-Scale Prospective Cohort Study. Other

The American journal … 2025

CCL20 expression is elevated in inflammatory bowel disease and attenuated by vitamin D metabolites. Other

Scientific reports 2025

Osteoporosis: A Review. Review

JAMA 2025

Intestinal Barrier Impairment, Preservation, and Repair: An Update. Review

Nutrients 2024 47 citations

Contemporary Perspectives on the Role of Vitamin D in Enhancing Gut Health and Its Implications for Preventing and Managing Intestinal … Review

Nutrients 2024 27 citations

Bone health in patients with inflammatory bowel disease. Review

Swiss medical weekly 2024 9 citations

[Role of diet in the prevention and development of Crohn's Disease]. Review

Nutricion hospitalaria 2024 2 citations

Vitamin D and CRP are associated in hospitalized inflammatory bowel disease (IBD) patients in Shanghai. Other

Asia Pacific journal … 2024 1 citations

Vitamin D: immune function, inflammation, infections and auto-immunity. Review

Paediatrics and international … 2023 48 citations

Vitamin D and Microbiome: Molecular Interaction in Inflammatory Bowel Disease Pathogenesis. Review

The American journal … 2023 37 citations

Vitamin D therapy in pediatric patients with inflammatory bowel disease: a systematic review and meta-analysis. Meta-Analysis

World journal of … 2023 11 citations

Association between vitamin D level and pediatric inflammatory bowel disease: A systematic review and meta-analysis. Review

Frontiers in pediatrics 2023 6 citations

Assessing vitamin D as a biomarker in inflammatory bowel disease. Other

JGH open : … 2023 5 citations

Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model. Other

Toxicology mechanisms and … 2023 5 citations

Body Composition in Inflammatory Bowel Disease. Review

Archives of Iranian … 2023 2 citations

Vitamin D for the treatment of inflammatory bowel disease. Systematic Review

The Cochrane database … 2023 1 citations

Autoimmune disease and interconnections with vitamin D. Review

Endocrine connections 2022 50 citations

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease. Review

Journal of inflammation … 2022 50 citations

Molecular basis of vitamin D action in inflammatory bowel disease. Review

Autoimmunity reviews 2022 44 citations

Vitamin D in Prevention of Autoimmune Diseases. Review

Frontiers in bioscience … 2022 17 citations

Identification of putative transcriptomic biomarkers in irritable bowel syndrome (IBS): Differential gene expression and regulation of TPH1 and SERT by … Other

PloS one 2022 10 citations

Vitamin D supplementation in inflammatory bowel disease: a narrative review. Review

Medwave 2022 4 citations

Diet supporting therapy for inflammatory bowel diseases. Review

European journal of … 2021 40 citations

Effects of oral vitamin D supplementation on inflammatory bowel disease: a systematic review and meta-analysis. Meta-Analysis

Food & function 2021 25 citations

Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review. Systematic Review

Nutrients 2021 16 citations

Vitamin D Therapy in Adults With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Meta-Analysis

Inflammatory bowel diseases 2020 57 citations

Mucosal vitamin D signaling in inflammatory bowel disease. Review

Autoimmunity reviews 2020 48 citations

Vitamin D in autoimmune bullous disease. Review

Acta biochimica Polonica 2020 10 citations

[Inflammatory Bowel Disease and Vitamin D]. Review

The Korean journal … 2020 3 citations

Vitamin D and inflammatory bowel disease: what do we know so far? Review

Revista espanola de … 2020 2 citations

The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management. Review

Nutrients 2019 193 citations

Managing vitamin D deficiency in inflammatory bowel disease. Review

Frontline gastroenterology 2019 58 citations

Associations between inflammatory bowel diseases and vitamin D. Review

Critical reviews in … 2019 45 citations

Vitamin D in inflammatory bowel disease: From biology to clinical implications. Review

Complementary therapies in … 2019 27 citations

Vitamin D in Inflammatory Bowel Disease: Biological, Clinical and Therapeutic Aspects. Review

Current drug metabolism 2019 7 citations

Nutritional regulators of intestinal inflammation. Review

Current opinion in … 2019 5 citations

Vitamin D in inflammatory bowel disease: more than just a supplement. Review

Current opinion in … 2018 94 citations

Nutritional Interventions in the Patient with Inflammatory Bowel Disease. Review

Gastroenterology clinics of … 2018 67 citations

Vitamin D, the gut microbiome and inflammatory bowel disease. Review

Journal of research … 2018 48 citations

Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what … Systematic Review

European journal of … 2018 39 citations

Diet as a Trigger or Therapy for Inflammatory Bowel Diseases. Other

Gastroenterology 2017 335 citations

Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease: Systematic Review and Meta-Analysis. Meta-Analysis

Journal of clinical … 2017 73 citations

Role of Vitamin D in Inflammatory Bowel Disease. Review

Nutrition in clinical … 2017 55 citations

Vitamin D status in pediatric irritable bowel syndrome. Other

PloS one 2017 38 citations

Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands. Review

Current medicinal chemistry 2017 14 citations

Vitamin D Levels and Outcomes in Inflammatory Bowel Disease-Which is the Chicken and Which is the Egg? Other

Clinical gastroenterology and … 2017 8 citations

[Nutrition and dietary supplement in chronic inflammatory bowel diesease]. Review

Ugeskrift for laeger 2017

Diet and nutritional factors in inflammatory bowel diseases. Review

World journal of … 2016 238 citations

Protective links between vitamin D, inflammatory bowel disease and colon cancer. Review

World journal of … 2016 122 citations

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 citations

Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis. Review

Current pharmaceutical design 2016 32 citations

Vitamin D and the Pathogenesis of Inflammatory Bowel Disease. Review

Current gastroenterology reports 2016 22 citations

Reflections About Inflammatory Bowel Disease and Vitamins A and D. Review

Journal of medicinal … 2016 17 citations

Vitamin D and Inflammatory Bowel Disease. Other

Gastroenterology & hepatology 2016 7 citations

Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis. Meta-Analysis

Inflammatory bowel diseases 2015 214 citations

Vitamin D and inflammatory bowel disease. Review

BioMed research international 2015 149 citations

Role of vitamins in gastrointestinal diseases. Review

World journal of … 2015 62 citations

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn? Review

The Proceedings of … 2015 46 citations

The Role of Vitamin D in Inflammatory Bowel Disease. Review

Healthcare (Basel, Switzerland) 2015 7 citations

Vitamin D and inflammatory diseases. Review

Journal of inflammation … 2014 411 citations

Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease. Review

Experimental biology and … 2014 131 citations

Vitamin D improves inflammatory bowel disease outcomes: basic science and clinical review. Review

World journal of … 2014 117 citations

Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. Other

Journal of pediatric … 2014 38 citations

Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. Review

Inflammatory bowel diseases 2012 224 citations

Review article: vitamin D and inflammatory bowel disease--established concepts and future directions. Review

Alimentary pharmacology & … 2012 111 citations

Vitamin D: new roles and therapeutic potential in inflammatory bowel disease. Review

Current drug metabolism 2012 28 citations

Vitamin D and inflammatory bowel disease. Review

Vitamins and hormones 2011 25 citations

Nutrition and inflammatory bowel disease: primary or adjuvant therapy. Review

Current opinion in … 2011 23 citations

Vitamin D and inflammation. Review

Joint bone spine 2010 281 citations

Vitamin D and autoimmune disease. Review

Acta medica Indonesiana 2007 4 citations

Mechanisms of disease: vitamin D and inflammatory bowel disease. Review

Nature clinical practice. … 2005 191 citations

Review article: nutrition and adult inflammatory bowel disease. Review

Alimentary pharmacology & … 2003 179 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:: 600-800 IU/day (RDA)
ibdsupport:: 1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
deficiencycorrection:: 50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance

Limite supérieure : 4,000 IU/day (100 mcg); higher doses under medical supervision only

Posologies étudiées dans la recherche

Posologie	Durée	Effet	N
None	--	Positive	--
None	--	Mixed	--
None	--	Positive	--
None	--	Neutral	--
None	--	Negative	193
None	--	Mixed	--
None	690 weeks	Neutral	357656
None	--	Positive	310

Moment optimal de prise : With a meal containing fat for better absorption

Safety & Side Effects

Effets indésirables signalés

⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
⚠ Kidney stones with excessive long-term supplementation
⚠ Constipation
⚠ Metallic taste

Interactions connues

● Thiazide diuretics (may increase risk of hypercalcemia)
● Corticosteroids (reduce vitamin D absorption and metabolism)
● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
● Statins (vitamin D may affect statin metabolism)

Apport maximal tolérable : 4,000 IU/day (100 mcg); higher doses under medical supervision only

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does Vitamin D help with Inflammatory Bowel Disease (IBD) — General?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Vitamin D may support Inflammatory Bowel Disease (IBD) — General management. Our evidence grade is B (Good Evidence).

How much Vitamin D should I take for Inflammatory Bowel Disease (IBD) — General?

Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion), Kidney stones with excessive long-term supplementation, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Inflammatory Bowel Disease (IBD) — General?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Related Evidence

Autres ingrédients pour Inflammatory Bowel Disease (IBD) — General

N-Acetyl Cysteine (NAC) D

Vitamin D pour d'autres pathologies

Irritable Bowel Syndrome (IBS) C

Verdict rapide

Supplementation (1,000-4,000 IU/day) reduces relapse risk in both UC and Crohn's. Deficiency is common in IBD (up to 60%) and correlates with disease severity.

Evidence Strength72%

High confidence

Synthèse des études

RCT (0)Meta (5)Other (5)

Comparer les alternatives

Découvrez comment d'autres ingrédients se comparent pour cette condition.Découvrez comment d'autres ingrédients se comparent pour cette pathologie.

Voir tous les ingrédients pour Inflammatory Bowel Disease (IBD) — General

En savoir plus

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