Vitamin D ： Inflammatory Bowel Disease (IBD) — General
BSupplementation (1,000-4,000 IU/day) reduces relapse risk in both UC and Crohn's. Deficiency is common in IBD (up to 60%) and correlates with disease severity.
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B
結論
Supplementation (1,000-4,000 IU/day) reduces relapse risk in both UC and Crohn's. Deficiency is common in IBD (up to 60%) and correlates with disease severity.
Key Study Findings
Review
Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future …
Dose: None
vs: None
Outcome: IBS symptom improvement with vitamin D supplementation
効果: None
None
対象集団: individuals with irritable bowel syndrome
Review
Diet in Ulcerative Colitis: A Narrative Review of Its Role in Pathogenesis and Treatment.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: patients with ulcerative colitis
Review
Probiotics in inflammatory bowel disease: microbial modulation and therapeutic prospects.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of probiotics as therapeutic strategy for inflammatory bowel disease
Review
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Dose: None
vs: None
Outcome: Micronutrient deficiency management in pediatric IBD
効果: None
None
対象集団: Children with inflammatory bowel disease (review)
Observational Study
n=193
The importance of vitamin D levels in patients with inflammatory bowel disease.
Dose: None
vs: Clinical activity groups and VD status groups
Outcome: Vitamin D levels and IBD activity markers
効果: None
0.009 (CD), 0.033 (UC), 0.032
対象集団: Greek IBD patients (122 CD, 71 UC)
Review
Osteoporosis: A Review.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Adults with osteoporosis
Key Statistics
10
研究数
1500
参加者数
↑
Positive
B
グレード
Referenced Papers
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4 件の引用
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2025
3 件の引用
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2025
CCL20 expression is elevated in inflammatory bowel disease and attenuated by vitamin D metabolites.
Other
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JAMA
2025
Nutrients
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47 件の引用
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37 件の引用
Vitamin D therapy in pediatric patients with inflammatory bowel disease: a systematic review and meta-analysis.
Meta-Analysis
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2023
11 件の引用
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2023
6 件の引用
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2021
40 件の引用
Effects of oral vitamin D supplementation on inflammatory bowel disease: a systematic review and meta-analysis.
Meta-Analysis
Food & function
2021
25 件の引用
Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review.
Systematic Review
Nutrients
2021
16 件の引用
Vitamin D Therapy in Adults With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Meta-Analysis
Inflammatory bowel diseases
2020
57 件の引用
Autoimmunity reviews
2020
48 件の引用
Acta biochimica Polonica
2020
10 件の引用
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2020
3 件の引用
Revista espanola de …
2020
2 件の引用
Nutrients
2019
193 件の引用
Frontline gastroenterology
2019
58 件の引用
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2019
45 件の引用
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2019
27 件の引用
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2019
7 件の引用
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2019
5 件の引用
Current opinion in …
2018
94 件の引用
Gastroenterology clinics of …
2018
67 件の引用
Journal of research …
2018
48 件の引用
Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what …
Systematic Review
European journal of …
2018
39 件の引用
Gastroenterology
2017
335 件の引用
Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.
Meta-Analysis
Journal of clinical …
2017
73 件の引用
Nutrition in clinical …
2017
55 件の引用
PloS one
2017
38 件の引用
Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands.
Review
Current medicinal chemistry
2017
14 件の引用
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2017
8 件の引用
Ugeskrift for laeger
2017
World journal of …
2016
238 件の引用
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2016
122 件の引用
Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?
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2016
41 件の引用
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2016
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2016
22 件の引用
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2016
17 件の引用
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2016
7 件の引用
Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis.
Meta-Analysis
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2015
214 件の引用
BioMed research international
2015
149 件の引用
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2015
62 件の引用
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2015
46 件の引用
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2015
7 件の引用
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2014
411 件の引用
Experimental biology and …
2014
131 件の引用
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2014
117 件の引用
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2014
38 件の引用
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2012
224 件の引用
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111 件の引用
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2012
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 600-800 IU/day (RDA)
- ibdsupport:
- 1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
- deficiencycorrection:
- 50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance
上限量： 4,000 IU/day (100 mcg); higher doses under medical supervision only
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Negative | 193 |
| None | -- | Mixed | -- |
| None | 690 weeks | Neutral | 357656 |
| None | -- | Positive | 310 |
推奨摂取タイミング： With a meal containing fat for better absorption
Safety & Side Effects
報告されている副作用
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
- ⚠ Kidney stones with excessive long-term supplementation
- ⚠ Constipation
- ⚠ Metallic taste
既知の相互作用
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
耐容上限摂取量： 4,000 IU/day (100 mcg); higher doses under medical supervision only
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Vitamin D help with Inflammatory Bowel Disease (IBD) — General?
Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Vitamin D may support Inflammatory Bowel Disease (IBD) — General management. Our evidence grade is B (Good Evidence).
How much Vitamin D should I take for Inflammatory Bowel Disease (IBD) — General?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion), Kidney stones with excessive long-term supplementation, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Inflammatory Bowel Disease (IBD) — General?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Inflammatory Bowel Disease (IBD) — General
Vitamin D 他の症状・状態について
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。