L-Glutamine для Irritable Bowel Syndrome (IBS)
C Доказательства Доказательства ограничены небольшими исследованиями, однако имеются некоторые положительные сигналы.Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.
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C
Итог
Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.
Key Study Findings
Other
Unraveling the active ingredients and molecular mechanisms of Qinghua Changyan granule against irritable bowel syndrome …
Dose: None
или: None
Outcome: IBS-D symptom relief via gut microbiota and glutamine …
Эффект: None
None
Популяция: animal model of IBS with diarrhea
Other
n=25
4 weeks
Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 …
Dose: Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917
или: phosphate-buffered saline (PBS)
Outcome: visceral hypersensitivity (abdominal withdrawal reflex scores)
Эффект: None
p<0.05
Популяция: female rats with water avoidance stress-induced IBS-D model
Other
n=62
[Study on activation mechanism of SGCs in representation along the distribution of stomach meridian in …
Dose: None
или: Control group (no citrobacter)
Outcome: SGC activation in DRG segments
Эффект: None
P<0.05 to P<0.01
Популяция: Male C57BL/6 mice (IBS-D model)
Review
Intestinal Barrier Impairment, Preservation, and Repair: An Update.
Dose: None
или: None
Outcome: Intestinal barrier preservation and repair
Эффект: None
None
Популяция: IBD and IBS patients (review)
Other
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.
Dose: None
или: None
Outcome: Cholesterol levels
Эффект: None
None
Популяция: Mouse model
In Vitro
Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …
Dose: None
или: None
Outcome: inflammation markers
Эффект: None
None
Популяция: Mice
Key Statistics
2
Исследования
150
Участники
↑
Positive
C
Оценка
Referenced Papers
Fitoterapia
2026
1 цитирований
Journal of the …
2026
Zhongguo zhen jiu …
2025
Nutrients
2024
47 цитирований
Cannabis and cannabinoid …
2024
10 цитирований
International journal of …
2023
9 цитирований
Journal of gastroenterology
2022
23 цитирований
NeuroImage. Clinical
2022
8 цитирований
Digestion
2021
29 цитирований
Frontiers in nutrition
2021
17 цитирований
Medicine
2021
Nutrition research (New …
2020
42 цитирований
World journal of …
2020
11 цитирований
Gut
2019
148 цитирований
Metabolomics : Official …
2019
41 цитирований
Pain
2019
23 цитирований
Scientific reports
2019
14 цитирований
Gut
2019
5 цитирований
[Not Available].
RCT
Praxis
2018
Current opinion in …
2017
71 цитирований
JPEN. Journal of …
2016
44 цитирований
Gastroenterology
2015
17 цитирований
Frontline gastroenterology
2012
20 цитирований
The American journal …
2011
48 цитирований
Clinical nutrition (Edinburgh, …
2011
12 цитирований
MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome.
Other
Gut
2010
263 цитирований
Clinics (Sao Paulo, …
2010
47 цитирований
Zhong xi yi …
2009
6 цитирований
Journal of clinical …
2008
73 цитирований
Nutrition in clinical …
2008
42 цитирований
Journal of proteome …
2006
80 цитирований
Medycyna wieku rozwojowego
2004
1 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 5-15 g/day
- ibsdsupport:
- 5 g three times daily (15 g/day total)
- postexercisegut:
- 0.25-0.9 g/kg before intense exercise
- gutbarriersupport:
- 0.5 g/kg/day (approximately 30-40 g/day for adults)
Верхний предел: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Positive | -- |
| Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 | 4 weeks | Positive | 25 |
| None | -- | Mixed | 62 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Negative | 75 |
Лучшее время приёма: Between meals or before exercise; divide doses throughout the day
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Headache
- ⚠ Dizziness at very high doses
- ⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)
Известные взаимодействия
- ● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
- ● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
- ● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)
Допустимый верхний уровень потребления: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does L-Glutamine help with Irritable Bowel Syndrome (IBS)?
Based on 2 studies with 150 participants, there is limited but promising evidence that L-Glutamine may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).
How much L-Glutamine should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Glutamine?
Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Glutamine and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Irritable Bowel Syndrome (IBS)
L-Glutamine для других состояний
References
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- [2] Nazila Dardmeh et al.. J Sci Food Agric. 2026. Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 on metabolic profiles in an … doi:10.1002/jsfa.70190 PubMed
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