L-Glutamine per Irritable Bowel Syndrome (IBS)

Q: Does L-Glutamine help with Irritable Bowel Syndrome (IBS)?

Based on 2 studies with 150 participants, there is limited but promising evidence that L-Glutamine may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).

Q: How much L-Glutamine should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of L-Glutamine?

Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for L-Glutamine and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.

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In sintesi

Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.

Key Study Findings

Other

Unraveling the active ingredients and molecular mechanisms of Qinghua Changyan granule against irritable bowel syndrome …

Dose: None vs: None Outcome: IBS-D symptom relief via gut microbiota and glutamine … Effetto: None None

Popolazione: animal model of IBS with diarrhea

Other n=25 4 weeks

Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 …

Dose: Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 vs: phosphate-buffered saline (PBS) Outcome: visceral hypersensitivity (abdominal withdrawal reflex scores) Effetto: None p<0.05

Popolazione: female rats with water avoidance stress-induced IBS-D model

Other n=62

[Study on activation mechanism of SGCs in representation along the distribution of stomach meridian in …

Dose: None vs: Control group (no citrobacter) Outcome: SGC activation in DRG segments Effetto: None P<0.05 to P<0.01

Popolazione: Male C57BL/6 mice (IBS-D model)

Review

Intestinal Barrier Impairment, Preservation, and Repair: An Update.

Dose: None vs: None Outcome: Intestinal barrier preservation and repair Effetto: None None

Popolazione: IBD and IBS patients (review)

Other

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.

Dose: None vs: None Outcome: Cholesterol levels Effetto: None None

Popolazione: Mouse model

In Vitro

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …

Dose: None vs: None Outcome: inflammation markers Effetto: None None

Popolazione: Mice

Key Statistics

Studi

150

Partecipanti

↑

Positive

Grado

Referenced Papers

Unraveling the active ingredients and molecular mechanisms of Qinghua Changyan granule against irritable bowel syndrome with diarrhea: Effects on gut … Other

Fitoterapia 2026 1 citazioni

Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 on metabolic profiles in an … Other

Journal of the … 2026

[Study on activation mechanism of SGCs in representation along the distribution of stomach meridian in IBS-D mice]. Other

Zhongguo zhen jiu … 2025

Intestinal Barrier Impairment, Preservation, and Repair: An Update. Review

Nutrients 2024 47 citazioni

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Other

Cannabis and cannabinoid … 2024 10 citazioni

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 citazioni

Omics profiles of fecal and oral microbiota change in irritable bowel syndrome patients with diarrhea and symptom exacerbation. Other

Journal of gastroenterology 2022 23 citazioni

Irritable bowel syndrome in women: Association between decreased insular subregion volumes and gastrointestinal symptoms. Other

NeuroImage. Clinical 2022 8 citazioni

Glutamine Blocks Interleukin-13-Induced Intestinal Epithelial Barrier Dysfunction. Other

Digestion 2021 29 citazioni

Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management. Other

Frontiers in nutrition 2021 17 citazioni

To assess the effective and safety of compound glutamine entersoluble capsules in irritable bowel syndrome: A protocol for systematic review … Other

Medicine 2021

Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. CCT

Nutrition research (New … 2020 42 citazioni

Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome. Review

World journal of … 2020 11 citazioni

Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. RCT

Gut 2019 148 citazioni

Metabolomics reveals elevated urinary excretion of collagen degradation and epithelial cell turnover products in irritable bowel syndrome patients. Other

Metabolomics : Official … 2019 41 citazioni

Reduced excitatory neurotransmitter levels in anterior insulae are associated with abdominal pain in irritable bowel syndrome. Other

Pain 2019 23 citazioni

Elucidating the putative link between prefrontal neurotransmission, functional connectivity, and affective symptoms in irritable bowel syndrome. Other

Scientific reports 2019 14 citazioni

Efficacy of glutamine in postinfection IBS. Other

Gut 2019 5 citazioni

[Not Available]. RCT

Praxis 2018

Glutamine and the regulation of intestinal permeability: from bench to bedside. Review

Current opinion in … 2017 71 citazioni

Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome. Other

JPEN. Journal of … 2016 44 citazioni

Intestinal permeability in patients with diarrhea-predominant irritable bowel syndrome: is there a place for glutamine supplementation? Other

Gastroenterology 2015 17 citazioni

Nutritional management of adults with inflammatory bowel disease: practical lessons from the available evidence. Review

Frontline gastroenterology 2012 20 citazioni

Reduced hippocampal glutamate-glutamine levels in irritable bowel syndrome: preliminary findings using magnetic resonance spectroscopy. Other

The American journal … 2011 48 citazioni

Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model. Other

Clinical nutrition (Edinburgh, … 2011 12 citazioni

MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Other

Gut 2010 263 citazioni

Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine. Review

Clinics (Sao Paulo, … 2010 47 citazioni

[Effects of Changjishu soft elastic capsule in treatment of diarrhea-predominant irritable bowel patients with liver-qi stagnation and spleen deficiency syndrome: … RCT

Zhong xi yi … 2009 6 citazioni

Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with irritable bowel syndrome: a multicenter, randomized … RCT

Journal of clinical … 2008 73 citazioni

Behavioral and complementary approaches for the treatment of irritable bowel syndrome. Review

Nutrition in clinical … 2008 42 citazioni

Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation. Other

Journal of proteome … 2006 80 citazioni

[Environmental factors in the etiopathology of inflammatory bowel syndrome]. Review

Medycyna wieku rozwojowego 2004 1 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 5-15 g/day
ibsdsupport:: 5 g three times daily (15 g/day total)
postexercisegut:: 0.25-0.9 g/kg before intense exercise
gutbarriersupport:: 0.5 g/kg/day (approximately 30-40 g/day for adults)

Limite massimo: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Positive	--
Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917	4 weeks	Positive	25
None	--	Mixed	62
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Negative	75

Momento migliore per l'assunzione: Between meals or before exercise; divide doses throughout the day

Safety & Side Effects

Effetti collaterali segnalati

⚠ Mild gastrointestinal discomfort at high doses
⚠ Headache
⚠ Dizziness at very high doses
⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)

Interazioni note

● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)

Livello di assunzione massimo tollerabile: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does L-Glutamine help with Irritable Bowel Syndrome (IBS)?

Based on 2 studies with 150 participants, there is limited but promising evidence that L-Glutamine may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).

How much L-Glutamine should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Glutamine?

Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Glutamine and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

L-Glutamine per altre condizioni

Crohn's Disease C Increased Intestinal Permeability (Leaky Gut) D

Verdetto rapido

Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.

Evidence Strength52%

Moderate confidence

Analisi degli studi

RCT (4)Meta (0)Other (0)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Irritable Bowel Syndrome (IBS)

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.