L-Glutamine para Irritable Bowel Syndrome (IBS)

Q: Does L-Glutamine help with Irritable Bowel Syndrome (IBS)?

Based on 2 studies with 150 participants, there is limited but promising evidence that L-Glutamine may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).

Q: How much L-Glutamine should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of L-Glutamine?

Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for L-Glutamine and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'gutcited.com'; const params = 'ingredient\u003Dl\u002Dglutamine\u0026condition\u003Dibs'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Conclusão

Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.

Key Study Findings

Other

Unraveling the active ingredients and molecular mechanisms of Qinghua Changyan granule against irritable bowel syndrome …

Dose: None vs: None Outcome: IBS-D symptom relief via gut microbiota and glutamine … Efeito: None None

População: animal model of IBS with diarrhea

Other n=25 4 weeks

Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 …

Dose: Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 vs: phosphate-buffered saline (PBS) Outcome: visceral hypersensitivity (abdominal withdrawal reflex scores) Efeito: None p<0.05

População: female rats with water avoidance stress-induced IBS-D model

Other n=62

[Study on activation mechanism of SGCs in representation along the distribution of stomach meridian in …

Dose: None vs: Control group (no citrobacter) Outcome: SGC activation in DRG segments Efeito: None P<0.05 to P<0.01

População: Male C57BL/6 mice (IBS-D model)

Review

Intestinal Barrier Impairment, Preservation, and Repair: An Update.

Dose: None vs: None Outcome: Intestinal barrier preservation and repair Efeito: None None

População: IBD and IBS patients (review)

Other

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.

Dose: None vs: None Outcome: Cholesterol levels Efeito: None None

População: Mouse model

In Vitro

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …

Dose: None vs: None Outcome: inflammation markers Efeito: None None

População: Mice

Key Statistics

Estudos

150

Participantes

↑

Positive

Nota

Referenced Papers

Unraveling the active ingredients and molecular mechanisms of Qinghua Changyan granule against irritable bowel syndrome with diarrhea: Effects on gut … Other

Fitoterapia 2026 1 citações

Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 on metabolic profiles in an … Other

Journal of the … 2026

[Study on activation mechanism of SGCs in representation along the distribution of stomach meridian in IBS-D mice]. Other

Zhongguo zhen jiu … 2025

Intestinal Barrier Impairment, Preservation, and Repair: An Update. Review

Nutrients 2024 47 citações

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Other

Cannabis and cannabinoid … 2024 10 citações

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 citações

Omics profiles of fecal and oral microbiota change in irritable bowel syndrome patients with diarrhea and symptom exacerbation. Other

Journal of gastroenterology 2022 23 citações

Irritable bowel syndrome in women: Association between decreased insular subregion volumes and gastrointestinal symptoms. Other

NeuroImage. Clinical 2022 8 citações

Glutamine Blocks Interleukin-13-Induced Intestinal Epithelial Barrier Dysfunction. Other

Digestion 2021 29 citações

Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management. Other

Frontiers in nutrition 2021 17 citações

To assess the effective and safety of compound glutamine entersoluble capsules in irritable bowel syndrome: A protocol for systematic review … Other

Medicine 2021

Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. CCT

Nutrition research (New … 2020 42 citações

Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome. Review

World journal of … 2020 11 citações

Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. RCT

Gut 2019 148 citações

Metabolomics reveals elevated urinary excretion of collagen degradation and epithelial cell turnover products in irritable bowel syndrome patients. Other

Metabolomics : Official … 2019 41 citações

Reduced excitatory neurotransmitter levels in anterior insulae are associated with abdominal pain in irritable bowel syndrome. Other

Pain 2019 23 citações

Elucidating the putative link between prefrontal neurotransmission, functional connectivity, and affective symptoms in irritable bowel syndrome. Other

Scientific reports 2019 14 citações

Efficacy of glutamine in postinfection IBS. Other

Gut 2019 5 citações

[Not Available]. RCT

Praxis 2018

Glutamine and the regulation of intestinal permeability: from bench to bedside. Review

Current opinion in … 2017 71 citações

Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome. Other

JPEN. Journal of … 2016 44 citações

Intestinal permeability in patients with diarrhea-predominant irritable bowel syndrome: is there a place for glutamine supplementation? Other

Gastroenterology 2015 17 citações

Nutritional management of adults with inflammatory bowel disease: practical lessons from the available evidence. Review

Frontline gastroenterology 2012 20 citações

Reduced hippocampal glutamate-glutamine levels in irritable bowel syndrome: preliminary findings using magnetic resonance spectroscopy. Other

The American journal … 2011 48 citações

Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model. Other

Clinical nutrition (Edinburgh, … 2011 12 citações

MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Other

Gut 2010 263 citações

Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine. Review

Clinics (Sao Paulo, … 2010 47 citações

[Effects of Changjishu soft elastic capsule in treatment of diarrhea-predominant irritable bowel patients with liver-qi stagnation and spleen deficiency syndrome: … RCT

Zhong xi yi … 2009 6 citações

Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with irritable bowel syndrome: a multicenter, randomized … RCT

Journal of clinical … 2008 73 citações

Behavioral and complementary approaches for the treatment of irritable bowel syndrome. Review

Nutrition in clinical … 2008 42 citações

Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation. Other

Journal of proteome … 2006 80 citações

[Environmental factors in the etiopathology of inflammatory bowel syndrome]. Review

Medycyna wieku rozwojowego 2004 1 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:: 5-15 g/day
ibsdsupport:: 5 g three times daily (15 g/day total)
postexercisegut:: 0.25-0.9 g/kg before intense exercise
gutbarriersupport:: 0.5 g/kg/day (approximately 30-40 g/day for adults)

Limite superior: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
None	--	Positive	--
Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917	4 weeks	Positive	25
None	--	Mixed	62
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Negative	75

Melhor horário: Between meals or before exercise; divide doses throughout the day

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Mild gastrointestinal discomfort at high doses
⚠ Headache
⚠ Dizziness at very high doses
⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)

Interações Conhecidas

● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)

Ingestão máxima tolerável: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does L-Glutamine help with Irritable Bowel Syndrome (IBS)?

Based on 2 studies with 150 participants, there is limited but promising evidence that L-Glutamine may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).

How much L-Glutamine should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Glutamine?

Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Glutamine and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Related Evidence

Outros ingredientes para Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

L-Glutamine para outras condições

Crohn's Disease C Increased Intestinal Permeability (Leaky Gut) D

Veredito Rápido

Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.

Evidence Strength52%

Moderate confidence

Detalhamento dos Estudos

RCT (4)Meta (0)Other (0)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Irritable Bowel Syndrome (IBS)

Saiba Mais

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.