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Alpha-Galactosidase для Irritable Bowel Syndrome (IBS)

D Исследования Существуют только предварительные исследования (лабораторные исследования, описания случаев).

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

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            D

        

        

            
Итог

            
            
Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.
            
            

                
                Dose: None
                
                
                или: None
                
                
                Outcome: None
                
                
                Эффект: None
                
                
                None
                
            

            
            
Популяция: None

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                
                Double-blind
                
            

            
                A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal …
            
            

                
                Dose: 1200 G
                
                
                или: placebo
                
                
                Outcome: every 30 min during 7
                
                
                Эффект: None
                
                
                None
                
            

            
            
Популяция: patients with ibs after three standardized

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=31
                
                
                2.0 weeks
                
                
                Double-blind
                
            

            
                Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.
            
            

                
                Dose: 300 GALU or 150 GALU
                
                
                или: Placebo (glucose)
                
                
                Outcome: GI symptom severity on VAS
                
                
                Эффект: None
                
                
                pP0.006
                
            

            
            
Популяция: IBS patients (Rome III, H2 producers)

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=125
                
                
                4 weeks
                
                
                Double-blind
                
            

            
                Does oral α-galactosidase relieve irritable bowel symptoms?
            
            

                
                Dose: alpha-galactosidase 600 GalU per meal
                
                
                или: placebo
                
                
                Outcome: overall IBS symptom relief
                
                
                Эффект: no significant difference vs placebo
                
                
                >0.05
                
            

            
            
Популяция: IBS patients

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
1

        
Исследования

    

    

        
60

        
Участники

    

    

        
            
            ↑
            
        
        
Positive

    

    

        D

        
Оценка

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        International journal of …
                        2021
                        
                        16 цитирований
                        
                    

                

                
                

                    

                        
                            A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Neurogastroenterology and motility
                        2021
                        
                        4 цитирований
                        
                    

                

                
                

                    

                        
                            Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        The American journal …
                        2018
                        
                        49 цитирований
                        
                    

                

                
                

                    

                        
                            Does oral α-galactosidase relieve irritable bowel symptoms?
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Scandinavian journal of …
                        2016
                        
                        17 цитирований
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Часто используемые дозировки

                

                    
                    

                        
general:

                        
150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods

                    

                    
                    

                        
standardbeanodose:

                        
300 GalU (2-3 tablets) with first bite of problem food

                    

                    
                

                
                

                    Верхний предел: No established upper limit; adjust per meal as needed
                

                
            

            

            
            

                
Дозировки, изученные в исследованиях

                

                    

                        
                            

                                Дозировка
                                Длительность
                                Эффект
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                1200 G
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                            

                                300 GALU or 150 GALU
                                2.0 weeks
                                
                                    
                                    Positive
                                    
                                
                                31
                            

                            
                            

                                alpha-galactosidase 600 GalU per meal
                                4 weeks
                                
                                    
                                    Neutral
                                    
                                
                                125
                            

                            
                        
                    

                

            

            

            
            

                Лучшее время приёма: With the first bite of gas-producing food
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Зарегистрированные побочные эффекты

                    
    
                        
                        
  • 
                            ⚠
                            Generally very well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare allergic reactions to mold-derived enzyme (Aspergillus source)
                        
    • 
                        
                        
  • 
                            ⚠
                            May cause mild GI discomfort in rare cases
                        
    • 
                        
                    

                

                

                
                

                    
Известные взаимодействия

                    
    
                        
                        
  • 
                            ●
                            Acarbose (alpha-galactosidase may counteract the blood sugar-lowering mechanism of acarbose; contraindicated for concurrent use)
                        
    • 
                        
                        
  • 
                            ●
                            Miglitol (similar mechanism conflict as acarbose)
                        
    • 
                        
                    

                

                

                
                

                    

                        Допустимый верхний уровень потребления: No established upper limit; adjust per meal as needed
                    

                

                
            

            

                Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Alpha-Galactosidase help with Irritable Bowel Syndrome (IBS)?
            
        
        

            Based on 1 studies with 60 participants, there is preliminary evidence that needs more research that Alpha-Galactosidase may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is D (Very Early Research).
        

    

    
    

        
            How much Alpha-Galactosidase should I take for Irritable Bowel Syndrome (IBS)?
            
        
        

            Studies have used various dosages. A commonly studied range is 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Alpha-Galactosidase?
            
        
        

            Reported side effects may include Generally very well-tolerated, Rare allergic reactions to mold-derived enzyme (Aspergillus source), May cause mild GI discomfort in rare cases. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Alpha-Galactosidase and Irritable Bowel Syndrome (IBS)?
            
        
        

            We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 60 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Alpha-Galactosidase для других состояний

                    

                        
                        
                            Bloating and Intestinal Gas
                            B

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Fabio Caputo et al..
      Int J Environ Res Public Health.
      2021.
      Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.
      doi:10.3390/ijerph18063320
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Lena Böhn et al..
      Neurogastroenterol Motil.
      2021.
      A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome …
      doi:10.1111/nmo.14094
      PubMed
    
    3. 
    
    
  3. 
      [3]
      C J Tuck et al..
      Am J Gastroenterol.
      2018.
      Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.
      doi:10.1038/ajg.2017.245
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Markku Hillilä et al..
      Scand J Gastroenterol.
      2016.
      Does oral α-galactosidase relieve irritable bowel symptoms?
      doi:10.3109/00365521.2015.1063156
      PubMed
    
    5. 
    
  















    

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