L-Glutamine لـ Irritable Bowel Syndrome (IBS)
C الأدلة أدلة محدودة من دراسات صغيرة، غير أن ثمة بعض الإشارات الإيجابية.Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.
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C
الخلاصة
Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.
Key Study Findings
Other
Unraveling the active ingredients and molecular mechanisms of Qinghua Changyan granule against irritable bowel syndrome …
Dose: None
مقابل: None
Outcome: IBS-D symptom relief via gut microbiota and glutamine …
التأثير: None
None
المجتمع المدروس: animal model of IBS with diarrhea
Other
n=25
4 weeks
Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 …
Dose: Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917
مقابل: phosphate-buffered saline (PBS)
Outcome: visceral hypersensitivity (abdominal withdrawal reflex scores)
التأثير: None
p<0.05
المجتمع المدروس: female rats with water avoidance stress-induced IBS-D model
Other
n=62
[Study on activation mechanism of SGCs in representation along the distribution of stomach meridian in …
Dose: None
مقابل: Control group (no citrobacter)
Outcome: SGC activation in DRG segments
التأثير: None
P<0.05 to P<0.01
المجتمع المدروس: Male C57BL/6 mice (IBS-D model)
Review
Intestinal Barrier Impairment, Preservation, and Repair: An Update.
Dose: None
مقابل: None
Outcome: Intestinal barrier preservation and repair
التأثير: None
None
المجتمع المدروس: IBD and IBS patients (review)
Other
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.
Dose: None
مقابل: None
Outcome: Cholesterol levels
التأثير: None
None
المجتمع المدروس: Mouse model
In Vitro
Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …
Dose: None
مقابل: None
Outcome: inflammation markers
التأثير: None
None
المجتمع المدروس: Mice
Key Statistics
2
الدراسات
150
المشاركون
↑
Positive
C
التقييم
Referenced Papers
Fitoterapia
2026
1 اقتباسات
Journal of the …
2026
Zhongguo zhen jiu …
2025
Nutrients
2024
47 اقتباسات
Cannabis and cannabinoid …
2024
10 اقتباسات
International journal of …
2023
9 اقتباسات
Journal of gastroenterology
2022
23 اقتباسات
NeuroImage. Clinical
2022
8 اقتباسات
Digestion
2021
29 اقتباسات
Frontiers in nutrition
2021
17 اقتباسات
Medicine
2021
Nutrition research (New …
2020
42 اقتباسات
World journal of …
2020
11 اقتباسات
Gut
2019
148 اقتباسات
Metabolomics : Official …
2019
41 اقتباسات
Pain
2019
23 اقتباسات
Scientific reports
2019
14 اقتباسات
Gut
2019
5 اقتباسات
[Not Available].
RCT
Praxis
2018
Current opinion in …
2017
71 اقتباسات
JPEN. Journal of …
2016
44 اقتباسات
Gastroenterology
2015
17 اقتباسات
Frontline gastroenterology
2012
20 اقتباسات
The American journal …
2011
48 اقتباسات
Clinical nutrition (Edinburgh, …
2011
12 اقتباسات
MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome.
Other
Gut
2010
263 اقتباسات
Clinics (Sao Paulo, …
2010
47 اقتباسات
Zhong xi yi …
2009
6 اقتباسات
Journal of clinical …
2008
73 اقتباسات
Nutrition in clinical …
2008
42 اقتباسات
Journal of proteome …
2006
80 اقتباسات
Medycyna wieku rozwojowego
2004
1 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 5-15 g/day
- ibsdsupport:
- 5 g three times daily (15 g/day total)
- postexercisegut:
- 0.25-0.9 g/kg before intense exercise
- gutbarriersupport:
- 0.5 g/kg/day (approximately 30-40 g/day for adults)
الحد الأعلى: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Positive | -- |
| Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 | 4 weeks | Positive | 25 |
| None | -- | Mixed | 62 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Negative | 75 |
أفضل وقت للتناول: Between meals or before exercise; divide doses throughout the day
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Headache
- ⚠ Dizziness at very high doses
- ⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)
التفاعلات المعروفة
- ● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
- ● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
- ● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)
الحد الأقصى المسموح به: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does L-Glutamine help with Irritable Bowel Syndrome (IBS)?
Based on 2 studies with 150 participants, there is limited but promising evidence that L-Glutamine may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).
How much L-Glutamine should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Glutamine?
Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Glutamine and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Irritable Bowel Syndrome (IBS)
L-Glutamine لحالات أخرى
References
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- [2] Nazila Dardmeh et al.. J Sci Food Agric. 2026. Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 on metabolic profiles in an … doi:10.1002/jsfa.70190 PubMed
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