L-Glutamine لـ Irritable Bowel Syndrome (IBS)

Q: Does L-Glutamine help with Irritable Bowel Syndrome (IBS)?

Based on 2 studies with 150 participants, there is limited but promising evidence that L-Glutamine may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).

Q: How much L-Glutamine should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of L-Glutamine?

Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for L-Glutamine and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.

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الخلاصة

Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.

Key Study Findings

Other

Unraveling the active ingredients and molecular mechanisms of Qinghua Changyan granule against irritable bowel syndrome …

Dose: None مقابل: None Outcome: IBS-D symptom relief via gut microbiota and glutamine … التأثير: None None

المجتمع المدروس: animal model of IBS with diarrhea

Other n=25 4 weeks

Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 …

Dose: Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 مقابل: phosphate-buffered saline (PBS) Outcome: visceral hypersensitivity (abdominal withdrawal reflex scores) التأثير: None p<0.05

المجتمع المدروس: female rats with water avoidance stress-induced IBS-D model

Other n=62

[Study on activation mechanism of SGCs in representation along the distribution of stomach meridian in …

Dose: None مقابل: Control group (no citrobacter) Outcome: SGC activation in DRG segments التأثير: None P<0.05 to P<0.01

المجتمع المدروس: Male C57BL/6 mice (IBS-D model)

Review

Intestinal Barrier Impairment, Preservation, and Repair: An Update.

Dose: None مقابل: None Outcome: Intestinal barrier preservation and repair التأثير: None None

المجتمع المدروس: IBD and IBS patients (review)

Other

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.

Dose: None مقابل: None Outcome: Cholesterol levels التأثير: None None

المجتمع المدروس: Mouse model

In Vitro

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …

Dose: None مقابل: None Outcome: inflammation markers التأثير: None None

المجتمع المدروس: Mice

Key Statistics

الدراسات

150

المشاركون

↑

Positive

التقييم

Referenced Papers

Unraveling the active ingredients and molecular mechanisms of Qinghua Changyan granule against irritable bowel syndrome with diarrhea: Effects on gut … Other

Fitoterapia 2026 1 اقتباسات

Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 on metabolic profiles in an … Other

Journal of the … 2026

[Study on activation mechanism of SGCs in representation along the distribution of stomach meridian in IBS-D mice]. Other

Zhongguo zhen jiu … 2025

Intestinal Barrier Impairment, Preservation, and Repair: An Update. Review

Nutrients 2024 47 اقتباسات

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Other

Cannabis and cannabinoid … 2024 10 اقتباسات

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 اقتباسات

Omics profiles of fecal and oral microbiota change in irritable bowel syndrome patients with diarrhea and symptom exacerbation. Other

Journal of gastroenterology 2022 23 اقتباسات

Irritable bowel syndrome in women: Association between decreased insular subregion volumes and gastrointestinal symptoms. Other

NeuroImage. Clinical 2022 8 اقتباسات

Glutamine Blocks Interleukin-13-Induced Intestinal Epithelial Barrier Dysfunction. Other

Digestion 2021 29 اقتباسات

Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management. Other

Frontiers in nutrition 2021 17 اقتباسات

To assess the effective and safety of compound glutamine entersoluble capsules in irritable bowel syndrome: A protocol for systematic review … Other

Medicine 2021

Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. CCT

Nutrition research (New … 2020 42 اقتباسات

Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome. Review

World journal of … 2020 11 اقتباسات

Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. RCT

Gut 2019 148 اقتباسات

Metabolomics reveals elevated urinary excretion of collagen degradation and epithelial cell turnover products in irritable bowel syndrome patients. Other

Metabolomics : Official … 2019 41 اقتباسات

Reduced excitatory neurotransmitter levels in anterior insulae are associated with abdominal pain in irritable bowel syndrome. Other

Pain 2019 23 اقتباسات

Elucidating the putative link between prefrontal neurotransmission, functional connectivity, and affective symptoms in irritable bowel syndrome. Other

Scientific reports 2019 14 اقتباسات

Efficacy of glutamine in postinfection IBS. Other

Gut 2019 5 اقتباسات

[Not Available]. RCT

Praxis 2018

Glutamine and the regulation of intestinal permeability: from bench to bedside. Review

Current opinion in … 2017 71 اقتباسات

Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome. Other

JPEN. Journal of … 2016 44 اقتباسات

Intestinal permeability in patients with diarrhea-predominant irritable bowel syndrome: is there a place for glutamine supplementation? Other

Gastroenterology 2015 17 اقتباسات

Nutritional management of adults with inflammatory bowel disease: practical lessons from the available evidence. Review

Frontline gastroenterology 2012 20 اقتباسات

Reduced hippocampal glutamate-glutamine levels in irritable bowel syndrome: preliminary findings using magnetic resonance spectroscopy. Other

The American journal … 2011 48 اقتباسات

Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model. Other

Clinical nutrition (Edinburgh, … 2011 12 اقتباسات

MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Other

Gut 2010 263 اقتباسات

Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine. Review

Clinics (Sao Paulo, … 2010 47 اقتباسات

[Effects of Changjishu soft elastic capsule in treatment of diarrhea-predominant irritable bowel patients with liver-qi stagnation and spleen deficiency syndrome: … RCT

Zhong xi yi … 2009 6 اقتباسات

Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with irritable bowel syndrome: a multicenter, randomized … RCT

Journal of clinical … 2008 73 اقتباسات

Behavioral and complementary approaches for the treatment of irritable bowel syndrome. Review

Nutrition in clinical … 2008 42 اقتباسات

Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation. Other

Journal of proteome … 2006 80 اقتباسات

[Environmental factors in the etiopathology of inflammatory bowel syndrome]. Review

Medycyna wieku rozwojowego 2004 1 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 5-15 g/day
ibsdsupport:: 5 g three times daily (15 g/day total)
postexercisegut:: 0.25-0.9 g/kg before intense exercise
gutbarriersupport:: 0.5 g/kg/day (approximately 30-40 g/day for adults)

الحد الأعلى: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Positive	--
Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917	4 weeks	Positive	25
None	--	Mixed	62
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Negative	75

أفضل وقت للتناول: Between meals or before exercise; divide doses throughout the day

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Mild gastrointestinal discomfort at high doses
⚠ Headache
⚠ Dizziness at very high doses
⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)

التفاعلات المعروفة

● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)

الحد الأقصى المسموح به: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does L-Glutamine help with Irritable Bowel Syndrome (IBS)?

Based on 2 studies with 150 participants, there is limited but promising evidence that L-Glutamine may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).

How much L-Glutamine should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Glutamine?

Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Glutamine and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Related Evidence

مكونات أخرى لـ Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

L-Glutamine لحالات أخرى

Crohn's Disease C Increased Intestinal Permeability (Leaky Gut) D

الخلاصة السريعة

Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.

Evidence Strength52%

Moderate confidence

تفصيل الدراسات

RCT (4)Meta (0)Other (0)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Irritable Bowel Syndrome (IBS)

اعرف المزيد

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.