Vitamin A لـ Increased Intestinal Permeability (Leaky Gut)
CRetinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
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C
الخلاصة
Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
Key Study Findings
Observational Study
n=54
Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in …
Dose: None
مقابل: None
Outcome: Intestinal permeability (lactulose:mannitol ratio)
التأثير: AOR 0.15 (CI 0.05-0.42) for retinol
<0.001
المجتمع المدروس: Community-dwelling elderly individuals
Other
12 weeks
Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.
Dose: None
مقابل: HFD control mice
Outcome: NAFLD biomarkers and gut microbiota composition
التأثير: None
None
المجتمع المدروس: HFD-induced NAFLD mouse model
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
مقابل: None
Outcome: Athletic performance and nutritional optimization
التأثير: None
None
المجتمع المدروس: Vegan athletes (narrative review)
Observational Study
Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …
Dose: None
مقابل: None
Outcome: DALYs and mortality rates of congenital birth defects
التأثير: DALYs decreased 59.77%, deaths decreased 63.81%
None
المجتمع المدروس: G20 countries population, 1990-2021
Other
12 weeks
Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and …
Dose: None
مقابل: None
Outcome: Cognitive function
التأثير: None
None
المجتمع المدروس: Mouse model (APP/PS1)
In Vitro
Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress.
Dose: None
مقابل: None
Outcome: oxidative stress markers
التأثير: None
p < 0.05
المجتمع المدروس: Chickens
Key Statistics
3
الدراسات
250
المشاركون
↑
Positive
C
التقييم
Referenced Papers
BMC pregnancy and …
2025
6 اقتباسات
Current nutrition reports
2025
3 اقتباسات
NPJ science of …
2025
2 اقتباسات
Scientific reports
2025
Frontiers in nutrition
2024
12 اقتباسات
Journal of animal …
2023
11 اقتباسات
Food science & …
2023
2 اقتباسات
International journal of …
2022
60 اقتباسات
Journal of Nippon …
2021
26 اقتباسات
Frontiers in immunology
2021
8 اقتباسات
Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A …
Systematic Review
Psychiatry research
2020
60 اقتباسات
Journal of diabetes …
2020
11 اقتباسات
Blood
2017
49 اقتباسات
ACS chemical neuroscience
2017
20 اقتباسات
World journal of …
2016
238 اقتباسات
Clinics in dermatology
2016
19 اقتباسات
The Journal of …
2015
31 اقتباسات
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Other
Journal of pediatric …
2014
38 اقتباسات
Nutrition and cancer
2014
5 اقتباسات
Blood
2013
54 اقتباسات
European journal of …
2012
225 اقتباسات
Journal of burn …
2012
16 اقتباسات
Medical oncology (Northwood, …
2010
12 اقتباسات
Scandinavian journal of …
2010
6 اقتباسات
Journal of nutritional …
2010
2 اقتباسات
European journal of …
2009
24 اقتباسات
Veterinary parasitology
2008
80 اقتباسات
Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.
Other
American journal of …
2008
25 اقتباسات
European journal of …
2005
2 اقتباسات
Journal of health, …
2003
The British journal …
2002
358 اقتباسات
Rossiiskii fiziologicheskii zhurnal …
2002
Journal of pediatric …
2001
56 اقتباسات
Journal of acquired …
2001
15 اقتباسات
The Pediatric infectious …
2000
14 اقتباسات
Life sciences
1998
35 اقتباسات
Biulleten' eksperimental'noi biologii …
1987
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 700-900 mcg RAE/day (RDA for adults)
- gutbarriersupport:
- 900 mcg RAE/day from mixed sources
- deficiencycorrection:
- 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)
الحد الأعلى: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Negative | 54 |
| None | 12 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 12 weeks | Negative | -- |
| None | -- | Positive | -- |
| None | 11 weeks | Positive | -- |
| 10 mg/kg | -- | Negative | -- |
أفضل وقت للتناول: With meals containing fat for better absorption
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Hepatotoxicity at chronic high doses of preformed vitamin A
- ⚠ Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
- ⚠ Nausea, headache, and dizziness
- ⚠ Bone density reduction with long-term excess
التفاعلات المعروفة
- ● Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
- ● Orlistat (reduces absorption of fat-soluble vitamins)
- ● Alcohol (increases hepatotoxicity risk of vitamin A)
- ● Tetracycline antibiotics (increased risk of intracranial pressure)
الحد الأقصى المسموح به: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Vitamin A help with Increased Intestinal Permeability (Leaky Gut)?
Based on 3 studies with 250 participants, there is limited but promising evidence that Vitamin A may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is C (Some Evidence).
How much Vitamin A should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin A?
Reported side effects may include Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin A and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Increased Intestinal Permeability (Leaky Gut)
Vitamin A لحالات أخرى
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.