Vitamin A para Increased Intestinal Permeability (Leaky Gut)

Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'gutcited.com'; const params = 'ingredient\u003Dvitamin\u002Da\u0026condition\u003Dintestinal\u002Dpermeability'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Conclusión

Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.

Key Study Findings

Observational Study n=54

Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in …

Dose: None vs: None Outcome: Intestinal permeability (lactulose:mannitol ratio) Efecto: AOR 0.15 (CI 0.05-0.42) for retinol <0.001

Población: Community-dwelling elderly individuals

Other 12 weeks

Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.

Dose: None vs: HFD control mice Outcome: NAFLD biomarkers and gut microbiota composition Efecto: None None

Población: HFD-induced NAFLD mouse model

Review

Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.

Dose: None vs: None Outcome: Athletic performance and nutritional optimization Efecto: None None

Población: Vegan athletes (narrative review)

Observational Study

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …

Dose: None vs: None Outcome: DALYs and mortality rates of congenital birth defects Efecto: DALYs decreased 59.77%, deaths decreased 63.81% None

Población: G20 countries population, 1990-2021

Other 12 weeks

Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and …

Dose: None vs: None Outcome: Cognitive function Efecto: None None

Población: Mouse model (APP/PS1)

In Vitro

Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress.

Dose: None vs: None Outcome: oxidative stress markers Efecto: None p < 0.05

Población: Chickens

Key Statistics

Estudios

250

Participantes

↑

Positive

Calificación

Referenced Papers

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions for 2022-2040. Other

BMC pregnancy and … 2025 6 citas

Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review. Review

Current nutrition reports 2025 3 citas

Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics. Other

NPJ science of … 2025 2 citas

Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population. Other

Scientific reports 2025

Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and the release of inflammatory factors, … Other

Frontiers in nutrition 2024 12 citas

Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress. Other

Journal of animal … 2023 11 citas

Maternal Vitamin A deficiency during pregnancy and lactation induced damaged intestinal structure and intestinal flora homeostasis in offspring mice. Other

Food science & … 2023 2 citas

Crocetin Prolongs Recovery Period of DSS-Induced Colitis via Altering Intestinal Microbiome and Increasing Intestinal Permeability. Other

International journal of … 2022 60 citas

Nutrition and Atopic Dermatitis. Other

Journal of Nippon … 2021 26 citas

Retinoic Acid Signaling Modulates Recipient Gut Barrier Integrity and Microbiota After Allogeneic Hematopoietic Stem Cell Transplantation in Mice. Other

Frontiers in immunology 2021 8 citas

Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A … Systematic Review

Psychiatry research 2020 60 citas

Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency. Other

Journal of diabetes … 2020 11 citas

Lower levels of vitamin A are associated with increased gastrointestinal graft-versus-host disease in children. Other

Blood 2017 49 citas

Vitamin-Derived Nanolipoidal Carriers for Brain Delivery of Dimethyl Fumarate: A Novel Approach with Preclinical Evidence. Other

ACS chemical neuroscience 2017 20 citas

Diet and nutritional factors in inflammatory bowel diseases. Review

World journal of … 2016 238 citas

Nutrition and skin: Kids are not just little people. Review

Clinics in dermatology 2016 19 citas

Protective effect of crocetin against burn-induced intestinal injury. Other

The Journal of … 2015 31 citas

Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. Other

Journal of pediatric … 2014 38 citas

Changes in intestinal permeability and nutritional status after cytotoxic therapy in patients with cancer. Other

Nutrition and cancer 2014 5 citas

Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration. Other

Blood 2013 54 citas

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 citas

Zinc supplementation in burn patients. Other

Journal of burn … 2012 16 citas

Intestinal permeability, vitamin A absorption, alpha-tocopherol, and neopterin in patients with rectal carcinoma treated with chemoradiation. Other

Medical oncology (Northwood, … 2010 12 citas

Intestinal permeability, vitamin A absorption and serum alpha-tocopherol during therapy with gefitinib. Other

Scandinavian journal of … 2010 6 citas

Intestinal permeability, vitamin A absorption and serum alpha-tocopherol in gastrointestinal stromal tumor patients treated with imatinib. Other

Journal of nutritional … 2010 2 citas

Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: a randomized clinical trial. RCT

European journal of … 2009 24 citas

Effect of Cryptosporidium parvum infection on the absorptive capacity and paracellular permeability of the small intestine in neonatal calves. Other

Veterinary parasitology 2008 80 citas

Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea. Other

American journal of … 2008 25 citas

Acute but not chronic ethanol exposure impairs retinol oxidation in the small and large intestine of the rat. Other

European journal of … 2005 2 citas

Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil. Other

Journal of health, … 2003

The immune system: a target for functional foods? Review

The British journal … 2002 358 citas

[Effects of natural (zinc, vitamin E) and synthetic (diludin) antioxidants on the intestinal permeability in chicks with vitamin A deficiency]. Other

Rossiiskii fiziologicheskii zhurnal … 2002

The effect of antenatal vitamin A and beta-carotene supplementation on gut integrity of infants of HIV-infected South African women. RCT

Journal of pediatric … 2001 56 citas

Feeding mode, intestinal permeability, and neopterin excretion: a longitudinal study in infants of HIV-infected South African women. RCT

Journal of acquired … 2001 15 citas

Vitamin A supplementation of South African children with severe diarrhea: optimum timing for improving biochemical and clinical recovery and subsequent … RCT

The Pediatric infectious … 2000 14 citas

Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice. Other

Life sciences 1998 35 citas

[Effect of vitamin A deficiency on the macromolecular permeability of small intestine mucosa in the adult rat]. Other

Biulleten' eksperimental'noi biologii … 1987

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 700-900 mcg RAE/day (RDA for adults)
gutbarriersupport:: 900 mcg RAE/day from mixed sources
deficiencycorrection:: 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)

Límite superior: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Negative	54
None	12 weeks	Positive	--
None	--	Positive	--
None	--	Positive	--
None	12 weeks	Negative	--
None	--	Positive	--
None	11 weeks	Positive	--
10 mg/kg	--	Negative	--

Mejor momento para tomar: With meals containing fat for better absorption

Safety & Side Effects

Efectos secundarios reportados

⚠ Hepatotoxicity at chronic high doses of preformed vitamin A
⚠ Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
⚠ Nausea, headache, and dizziness
⚠ Bone density reduction with long-term excess

Interacciones conocidas

● Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
● Orlistat (reduces absorption of fat-soluble vitamins)
● Alcohol (increases hepatotoxicity risk of vitamin A)
● Tetracycline antibiotics (increased risk of intracranial pressure)

Ingesta máxima tolerable: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Vitamin A help with Increased Intestinal Permeability (Leaky Gut)?

Based on 3 studies with 250 participants, there is limited but promising evidence that Vitamin A may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is C (Some Evidence).

How much Vitamin A should I take for Increased Intestinal Permeability (Leaky Gut)?

Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin A?

Reported side effects may include Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin A and Increased Intestinal Permeability (Leaky Gut)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.

Related Evidence

Otros ingredientes para Increased Intestinal Permeability (Leaky Gut)

Bovine Colostrum B Resistant Starch C Zinc Carnosine C L-Glutamine D

Vitamin A para otras condiciones

Acute Diarrhea D

Veredicto rápido

Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.

Evidence Strength52%

Moderate confidence

Desglose de estudios

RCT (4)Meta (0)Other (0)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Increased Intestinal Permeability (Leaky Gut)

Más información

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.