Vitamin A pour Increased Intestinal Permeability (Leaky Gut)
C Preuves Preuves limitées issues de petites études, mais certains signaux positifs existent.Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
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C
En conclusion
Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
Key Study Findings
Observational Study
n=54
Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in …
Dose: None
vs: None
Outcome: Intestinal permeability (lactulose:mannitol ratio)
Effet: AOR 0.15 (CI 0.05-0.42) for retinol
<0.001
Population: Community-dwelling elderly individuals
Other
12 weeks
Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.
Dose: None
vs: HFD control mice
Outcome: NAFLD biomarkers and gut microbiota composition
Effet: None
None
Population: HFD-induced NAFLD mouse model
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
vs: None
Outcome: Athletic performance and nutritional optimization
Effet: None
None
Population: Vegan athletes (narrative review)
Observational Study
Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …
Dose: None
vs: None
Outcome: DALYs and mortality rates of congenital birth defects
Effet: DALYs decreased 59.77%, deaths decreased 63.81%
None
Population: G20 countries population, 1990-2021
Other
12 weeks
Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and …
Dose: None
vs: None
Outcome: Cognitive function
Effet: None
None
Population: Mouse model (APP/PS1)
In Vitro
Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress.
Dose: None
vs: None
Outcome: oxidative stress markers
Effet: None
p < 0.05
Population: Chickens
Key Statistics
3
Études
250
Participants
↑
Positive
C
Note
Referenced Papers
BMC pregnancy and …
2025
6 citations
Current nutrition reports
2025
3 citations
NPJ science of …
2025
2 citations
Scientific reports
2025
Frontiers in nutrition
2024
12 citations
Journal of animal …
2023
11 citations
Food science & …
2023
2 citations
International journal of …
2022
60 citations
Journal of Nippon …
2021
26 citations
Frontiers in immunology
2021
8 citations
Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A …
Systematic Review
Psychiatry research
2020
60 citations
Journal of diabetes …
2020
11 citations
Blood
2017
49 citations
ACS chemical neuroscience
2017
20 citations
World journal of …
2016
238 citations
Clinics in dermatology
2016
19 citations
The Journal of …
2015
31 citations
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Other
Journal of pediatric …
2014
38 citations
Nutrition and cancer
2014
5 citations
Blood
2013
54 citations
European journal of …
2012
225 citations
Journal of burn …
2012
16 citations
Medical oncology (Northwood, …
2010
12 citations
Scandinavian journal of …
2010
6 citations
Journal of nutritional …
2010
2 citations
European journal of …
2009
24 citations
Veterinary parasitology
2008
80 citations
Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.
Other
American journal of …
2008
25 citations
European journal of …
2005
2 citations
Journal of health, …
2003
The British journal …
2002
358 citations
Rossiiskii fiziologicheskii zhurnal …
2002
Journal of pediatric …
2001
56 citations
Journal of acquired …
2001
15 citations
The Pediatric infectious …
2000
14 citations
Life sciences
1998
35 citations
Biulleten' eksperimental'noi biologii …
1987
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Posologies couramment utilisées
- general:
- 700-900 mcg RAE/day (RDA for adults)
- gutbarriersupport:
- 900 mcg RAE/day from mixed sources
- deficiencycorrection:
- 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)
Limite supérieure : 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
Posologies étudiées dans la recherche
| Posologie | Durée | Effet | N |
|---|---|---|---|
| None | -- | Negative | 54 |
| None | 12 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 12 weeks | Negative | -- |
| None | -- | Positive | -- |
| None | 11 weeks | Positive | -- |
| 10 mg/kg | -- | Negative | -- |
Moment optimal de prise : With meals containing fat for better absorption
Safety & Side Effects
Effets indésirables signalés
- ⚠ Hepatotoxicity at chronic high doses of preformed vitamin A
- ⚠ Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
- ⚠ Nausea, headache, and dizziness
- ⚠ Bone density reduction with long-term excess
Interactions connues
- ● Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
- ● Orlistat (reduces absorption of fat-soluble vitamins)
- ● Alcohol (increases hepatotoxicity risk of vitamin A)
- ● Tetracycline antibiotics (increased risk of intracranial pressure)
Apport maximal tolérable : 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
Frequently Asked Questions
Does Vitamin A help with Increased Intestinal Permeability (Leaky Gut)?
Based on 3 studies with 250 participants, there is limited but promising evidence that Vitamin A may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is C (Some Evidence).
How much Vitamin A should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin A?
Reported side effects may include Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin A and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
Related Evidence
Autres ingrédients pour Increased Intestinal Permeability (Leaky Gut)
Vitamin A pour d'autres pathologies
References
- [1] Xiangwen Li et al.. BMC Pregnancy Childbirth. 2025. Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions for 2022-2040. doi:10.1186/s12884-025-07617-w PubMed
- [2] Álvaro Vergara A Nieto et al.. Curr Nutr Rep. 2025. Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review. doi:10.1007/s13668-025-00633-4 PubMed
- [3] Siqi Wang et al.. NPJ Sci Food. 2025. Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics. doi:10.1038/s41538-025-00586-6 PubMed
- [4] Maria Clara da Cruz Carvalho et al.. Sci Rep. 2025. Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population. doi:10.1038/s41598-025-08045-8 PubMed
- [5] Zhong-Li Wang et al.. Front Nutr. 2024. Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and the release of inflammatory factors, … doi:10.3389/fnut.2024.1367086 PubMed
- [6] Hyun Woo Kim et al.. J Anim Sci Technol. 2023. Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress. doi:10.5187/jast.2023.e22 PubMed
- [7] Junming Zhou et al.. Food Sci Nutr. 2023. Maternal Vitamin A deficiency during pregnancy and lactation induced damaged intestinal structure and intestinal flora homeostasis in offspring mice. doi:10.1002/fsn3.3332 PubMed
- [8] Peishi Feng et al.. Int J Mol Sci. 2022. Crocetin Prolongs Recovery Period of DSS-Induced Colitis via Altering Intestinal Microbiome and Increasing Intestinal Permeability. doi:10.3390/ijms23073832 PubMed
- [9] Naoko Kanda et al.. J Nippon Med Sch. 2021. Nutrition and Atopic Dermatitis. doi:10.1272/jnms.JNMS.2021_88-317 PubMed
- [10] Pan Pan et al.. Front Immunol. 2021. Retinoic Acid Signaling Modulates Recipient Gut Barrier Integrity and Microbiota After Allogeneic Hematopoietic Stem Cell Transplantation in Mice. doi:10.3389/fimmu.2021.749002 PubMed
- [11] Jiaxin Yang et al.. Psychiatry Res. 2020. Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A … doi:10.1016/j.psychres.2020.113471 PubMed
- [12] Yunting Zhou et al.. J Diabetes Res. 2020. Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency. doi:10.1155/2020/2354108 PubMed
- [13] Dana T Lounder et al.. Blood. 2017. Lower levels of vitamin A are associated with increased gastrointestinal graft-versus-host disease in children. doi:10.1182/blood-2017-02-765826 PubMed
- [14] Pramod Kumar et al.. ACS Chem Neurosci. 2017. Vitamin-Derived Nanolipoidal Carriers for Brain Delivery of Dimethyl Fumarate: A Novel Approach with Preclinical Evidence. doi:10.1021/acschemneuro.7b00041 PubMed
- [15] Danuta Owczarek et al.. World J Gastroenterol. 2016. Diet and nutritional factors in inflammatory bowel diseases. doi:10.3748/wjg.v22.i3.895 PubMed
- [16] Meagen McCusker et al.. Clin Dermatol. 2016. Nutrition and skin: Kids are not just little people. doi:10.1016/j.clindermatol.2016.07.004 PubMed
- [17] Chunxiang Zhou et al.. J Surg Res. 2015. Protective effect of crocetin against burn-induced intestinal injury. doi:10.1016/j.jss.2015.05.052 PubMed
- [18] Neha R Santucci et al.. J Pediatr Gastroenterol Nutr. 2014. Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. doi:10.1097/MPG.0000000000000477 PubMed
- [19] Nilian C S Souza et al.. Nutr Cancer. 2014. Changes in intestinal permeability and nutritional status after cytotoxic therapy in patients with cancer. doi:10.1080/01635581.2014.894095 PubMed
- [20] Kazutoshi Aoyama et al.. Blood. 2013. Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration. doi:10.1182/blood-2012-11-470252 PubMed
- [21] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [22] Nancy Caldis-Coutris et al.. J Burn Care Res. 2012. Zinc supplementation in burn patients. doi:10.1097/BCR.0b013e31824799a3 PubMed
- [23] Josef Dvorák et al.. Med Oncol. 2010. Intestinal permeability, vitamin A absorption, alpha-tocopherol, and neopterin in patients with rectal carcinoma treated with chemoradiation. doi:10.1007/s12032-009-9270-4 PubMed
- [24] Bohuslav Melichar et al.. Scand J Clin Lab Invest. 2010. Intestinal permeability, vitamin A absorption and serum alpha-tocopherol during therapy with gefitinib. doi:10.3109/00365511003653581 PubMed
- [25] Bohuslav Melichar et al.. J Nutr Sci Vitaminol (Tokyo). 2010. Intestinal permeability, vitamin A absorption and serum alpha-tocopherol in gastrointestinal stromal tumor patients treated with imatinib. doi:10.3177/jnsv.56.347 PubMed
- [26] J L Rosado et al.. Eur J Clin Nutr. 2009. Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: a randomized clinical trial. doi:10.1038/ejcn.2009.53 PubMed
- [27] Pavel Klein et al.. Vet Parasitol. 2008. Effect of Cryptosporidium parvum infection on the absorptive capacity and paracellular permeability of the small intestine in neonatal calves. doi:10.1016/j.vetpar.2007.11.020 PubMed
- [28] Bohuslav Melichar et al.. Am J Clin Oncol. 2008. Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea. doi:10.1097/COC.0b013e318174dbb9 PubMed
- [29] Alexandr Parlesak et al.. Eur J Nutr. 2005. Acute but not chronic ethanol exposure impairs retinol oxidation in the small and large intestine of the rat. doi:10.1007/s00394-004-0507-x PubMed
- [30] Ping Chen et al.. J Health Popul Nutr. 2003. Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil. PubMed
- [31] Philip C Calder et al.. Br J Nutr. 2002. The immune system: a target for functional foods? doi:10.1079/BJN2002682 PubMed
- [32] N A Basova et al.. Ross Fiziol Zh Im I M Sechenova. 2002. [Effects of natural (zinc, vitamin E) and synthetic (diludin) antioxidants on the intestinal permeability in chicks with vitamin A deficiency]. PubMed
- [33] S M Filteau et al.. J Pediatr Gastroenterol Nutr. 2001. The effect of antenatal vitamin A and beta-carotene supplementation on gut integrity of infants of HIV-infected South African women. doi:10.1097/00005176-200104000-00014 PubMed
- [34] N C Rollins et al.. J Acquir Immune Defic Syndr. 2001. Feeding mode, intestinal permeability, and neopterin excretion: a longitudinal study in infants of HIV-infected South African women. doi:10.1097/00042560-200110010-00004 PubMed
- [35] N C Rollins et al.. Pediatr Infect Dis J. 2000. Vitamin A supplementation of South African children with severe diarrhea: optimum timing for improving biochemical and clinical recovery and subsequent … doi:10.1097/00006454-200004000-00004 PubMed
- [36] T Horie et al.. Life Sci. 1998. Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice. doi:10.1016/s0024-3205(98)00067-8 PubMed
- [37] I V Gmoshinskiĭ et al.. Biull Eksp Biol Med. 1987. [Effect of vitamin A deficiency on the macromolecular permeability of small intestine mucosa in the adult rat]. PubMed
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