Vitamin A для Increased Intestinal Permeability (Leaky Gut)
C Доказательства Доказательства ограничены небольшими исследованиями, однако имеются некоторые положительные сигналы.Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
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C
Итог
Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
Key Study Findings
Observational Study
n=54
Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in …
Dose: None
или: None
Outcome: Intestinal permeability (lactulose:mannitol ratio)
Эффект: AOR 0.15 (CI 0.05-0.42) for retinol
<0.001
Популяция: Community-dwelling elderly individuals
Other
12 weeks
Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.
Dose: None
или: HFD control mice
Outcome: NAFLD biomarkers and gut microbiota composition
Эффект: None
None
Популяция: HFD-induced NAFLD mouse model
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
или: None
Outcome: Athletic performance and nutritional optimization
Эффект: None
None
Популяция: Vegan athletes (narrative review)
Observational Study
Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …
Dose: None
или: None
Outcome: DALYs and mortality rates of congenital birth defects
Эффект: DALYs decreased 59.77%, deaths decreased 63.81%
None
Популяция: G20 countries population, 1990-2021
Other
12 weeks
Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and …
Dose: None
или: None
Outcome: Cognitive function
Эффект: None
None
Популяция: Mouse model (APP/PS1)
In Vitro
Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress.
Dose: None
или: None
Outcome: oxidative stress markers
Эффект: None
p < 0.05
Популяция: Chickens
Key Statistics
3
Исследования
250
Участники
↑
Positive
C
Оценка
Referenced Papers
BMC pregnancy and …
2025
6 цитирований
Current nutrition reports
2025
3 цитирований
NPJ science of …
2025
2 цитирований
Scientific reports
2025
Frontiers in nutrition
2024
12 цитирований
Journal of animal …
2023
11 цитирований
Food science & …
2023
2 цитирований
International journal of …
2022
60 цитирований
Journal of Nippon …
2021
26 цитирований
Frontiers in immunology
2021
8 цитирований
Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A …
Systematic Review
Psychiatry research
2020
60 цитирований
Journal of diabetes …
2020
11 цитирований
Blood
2017
49 цитирований
ACS chemical neuroscience
2017
20 цитирований
World journal of …
2016
238 цитирований
Clinics in dermatology
2016
19 цитирований
The Journal of …
2015
31 цитирований
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Other
Journal of pediatric …
2014
38 цитирований
Nutrition and cancer
2014
5 цитирований
Blood
2013
54 цитирований
European journal of …
2012
225 цитирований
Journal of burn …
2012
16 цитирований
Medical oncology (Northwood, …
2010
12 цитирований
Scandinavian journal of …
2010
6 цитирований
Journal of nutritional …
2010
2 цитирований
European journal of …
2009
24 цитирований
Veterinary parasitology
2008
80 цитирований
Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.
Other
American journal of …
2008
25 цитирований
European journal of …
2005
2 цитирований
Journal of health, …
2003
The British journal …
2002
358 цитирований
Rossiiskii fiziologicheskii zhurnal …
2002
Journal of pediatric …
2001
56 цитирований
Journal of acquired …
2001
15 цитирований
The Pediatric infectious …
2000
14 цитирований
Life sciences
1998
35 цитирований
Biulleten' eksperimental'noi biologii …
1987
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 700-900 mcg RAE/day (RDA for adults)
- gutbarriersupport:
- 900 mcg RAE/day from mixed sources
- deficiencycorrection:
- 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)
Верхний предел: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Negative | 54 |
| None | 12 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 12 weeks | Negative | -- |
| None | -- | Positive | -- |
| None | 11 weeks | Positive | -- |
| 10 mg/kg | -- | Negative | -- |
Лучшее время приёма: With meals containing fat for better absorption
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Hepatotoxicity at chronic high doses of preformed vitamin A
- ⚠ Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
- ⚠ Nausea, headache, and dizziness
- ⚠ Bone density reduction with long-term excess
Известные взаимодействия
- ● Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
- ● Orlistat (reduces absorption of fat-soluble vitamins)
- ● Alcohol (increases hepatotoxicity risk of vitamin A)
- ● Tetracycline antibiotics (increased risk of intracranial pressure)
Допустимый верхний уровень потребления: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Vitamin A help with Increased Intestinal Permeability (Leaky Gut)?
Based on 3 studies with 250 participants, there is limited but promising evidence that Vitamin A may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is C (Some Evidence).
How much Vitamin A should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin A?
Reported side effects may include Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin A and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Increased Intestinal Permeability (Leaky Gut)
Vitamin A для других состояний
References
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- [3] Siqi Wang et al.. NPJ Sci Food. 2025. Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics. doi:10.1038/s41538-025-00586-6 PubMed
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