Vitamin A ： Increased Intestinal Permeability (Leaky Gut)
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
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C
結論
Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
Key Study Findings
Observational Study
n=54
Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in …
Dose: None
vs: None
Outcome: Intestinal permeability (lactulose:mannitol ratio)
効果: AOR 0.15 (CI 0.05-0.42) for retinol
<0.001
対象集団: Community-dwelling elderly individuals
Other
12 weeks
Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.
Dose: None
vs: HFD control mice
Outcome: NAFLD biomarkers and gut microbiota composition
効果: None
None
対象集団: HFD-induced NAFLD mouse model
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
vs: None
Outcome: Athletic performance and nutritional optimization
効果: None
None
対象集団: Vegan athletes (narrative review)
Observational Study
Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …
Dose: None
vs: None
Outcome: DALYs and mortality rates of congenital birth defects
効果: DALYs decreased 59.77%, deaths decreased 63.81%
None
対象集団: G20 countries population, 1990-2021
Other
12 weeks
Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and …
Dose: None
vs: None
Outcome: Cognitive function
効果: None
None
対象集団: Mouse model (APP/PS1)
In Vitro
Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress.
Dose: None
vs: None
Outcome: oxidative stress markers
効果: None
p < 0.05
対象集団: Chickens
Key Statistics
3
研究数
250
参加者数
↑
Positive
C
グレード
Referenced Papers
BMC pregnancy and …
2025
6 件の引用
Current nutrition reports
2025
3 件の引用
NPJ science of …
2025
2 件の引用
Scientific reports
2025
Frontiers in nutrition
2024
12 件の引用
Journal of animal …
2023
11 件の引用
Food science & …
2023
2 件の引用
International journal of …
2022
60 件の引用
Journal of Nippon …
2021
26 件の引用
Frontiers in immunology
2021
8 件の引用
Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A …
Systematic Review
Psychiatry research
2020
60 件の引用
Journal of diabetes …
2020
11 件の引用
Blood
2017
49 件の引用
ACS chemical neuroscience
2017
20 件の引用
World journal of …
2016
238 件の引用
Clinics in dermatology
2016
19 件の引用
The Journal of …
2015
31 件の引用
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Other
Journal of pediatric …
2014
38 件の引用
Nutrition and cancer
2014
5 件の引用
Blood
2013
54 件の引用
European journal of …
2012
225 件の引用
Journal of burn …
2012
16 件の引用
Medical oncology (Northwood, …
2010
12 件の引用
Scandinavian journal of …
2010
6 件の引用
Journal of nutritional …
2010
2 件の引用
European journal of …
2009
24 件の引用
Veterinary parasitology
2008
80 件の引用
Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.
Other
American journal of …
2008
25 件の引用
European journal of …
2005
2 件の引用
Journal of health, …
2003
The British journal …
2002
358 件の引用
Rossiiskii fiziologicheskii zhurnal …
2002
Journal of pediatric …
2001
56 件の引用
Journal of acquired …
2001
15 件の引用
The Pediatric infectious …
2000
14 件の引用
Life sciences
1998
35 件の引用
Biulleten' eksperimental'noi biologii …
1987
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 700-900 mcg RAE/day (RDA for adults)
- gutbarriersupport:
- 900 mcg RAE/day from mixed sources
- deficiencycorrection:
- 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)
上限量： 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Negative | 54 |
| None | 12 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 12 weeks | Negative | -- |
| None | -- | Positive | -- |
| None | 11 weeks | Positive | -- |
| 10 mg/kg | -- | Negative | -- |
推奨摂取タイミング： With meals containing fat for better absorption
Safety & Side Effects
報告されている副作用
- ⚠ Hepatotoxicity at chronic high doses of preformed vitamin A
- ⚠ Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
- ⚠ Nausea, headache, and dizziness
- ⚠ Bone density reduction with long-term excess
既知の相互作用
- ● Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
- ● Orlistat (reduces absorption of fat-soluble vitamins)
- ● Alcohol (increases hepatotoxicity risk of vitamin A)
- ● Tetracycline antibiotics (increased risk of intracranial pressure)
耐容上限摂取量： 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Vitamin A help with Increased Intestinal Permeability (Leaky Gut)?
Based on 3 studies with 250 participants, there is limited but promising evidence that Vitamin A may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is C (Some Evidence).
How much Vitamin A should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin A?
Reported side effects may include Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin A and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Increased Intestinal Permeability (Leaky Gut)
Vitamin A 他の症状・状態について
References
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- [2] Álvaro Vergara A Nieto et al.. Curr Nutr Rep. 2025. Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review. doi:10.1007/s13668-025-00633-4 PubMed
- [3] Siqi Wang et al.. NPJ Sci Food. 2025. Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics. doi:10.1038/s41538-025-00586-6 PubMed
- [4] Maria Clara da Cruz Carvalho et al.. Sci Rep. 2025. Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population. doi:10.1038/s41598-025-08045-8 PubMed
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- [6] Hyun Woo Kim et al.. J Anim Sci Technol. 2023. Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress. doi:10.5187/jast.2023.e22 PubMed
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