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Deglycyrrhizinated Licorice (DGL) 관련 Peptic Ulcer Disease

C

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

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            C

        

        

            
결론

            
            
Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Systematic Review
                
                
                
                
            

            
                Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                효과: None
                
                
                None
                
            

            
            
대상 집단: the presence of dyspepsia in the absence of organic or metabolic causes

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive …
            
            

                
                Dose: Glycyrrhiza glabra flavonoid-rich extract
                
                
                vs: None
                
                
                Outcome: compatibility with probiotics and digestive enzymes
                
                
                효과: compatible with all tested strains
                
                
                None
                
            

            
            
대상 집단: Probiotic strains and enzymes (in vitro)

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence …
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                효과: None
                
                
                None
                
            

            
            
대상 집단: IBD patients (herbal therapy review)

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                4 weeks
                
                
                Double-blind
                
            

            
                An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled …
            
            

                
                Dose: 75 mg twice daily
                
                
                vs: Placebo
                
                
                Outcome: Functional dyspepsia symptom severity (SFLDQ)
                
                
                효과: None
                
                
                None
                
            

            
            
대상 집단: Adults with functional dyspepsia

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
2

        
연구

    

    

        
150

        
참여자

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
등급

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.
                        
                        
                            
                                Systematic Review
                            
                            
                            
                        
                    

                    

                        Current drug discovery …
                        2021
                        
                        16 인용
                        
                    

                

                
                

                    

                        
                            Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of dietary …
                        2017
                        
                        13 인용
                        
                    

                

                
                

                    

                        
                            Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Annals of gastroenterology
                        2016
                        
                        41 인용
                        
                    

                

                
                

                    

                        
                            An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Evidence-based complementary and …
                        2012
                        
                        70 인용
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
일반적으로 사용되는 용량

                

                    
                    

                        
general:

                        
380-760 mg DGL extract 3 times daily before meals

                    

                    
                    

                        
gastricsupport:

                        
760 mg before meals and at bedtime

                    

                    
                    

                        
dyspepsiasupport:

                        
380-400 mg chewable tablet 20 minutes before meals, 3 times daily

                    

                    
                

                
                

                    상한량: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
                

                
            

            

            
            

                
연구에서 사용된 용량

                

                    

                        
                            

                                용량
                                기간
                                효과
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                Glycyrrhiza glabra flavonoid-rich extract
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                75 mg twice daily
                                4 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                권장 복용 시간: 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
보고된 부작용

                    
    
                        
                        
  • 
                            ⚠
                            Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild nausea in rare cases
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache (uncommon)
                        
    • 
                        
                        
  • 
                            ⚠
                            If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)
                        
    • 
                        
                    

                

                

                
                

                    
알려진 상호작용

                    
    
                        
                        
  • 
                            ●
                            Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
                        
    • 
                        
                        
  • 
                            ●
                            Diuretics (if residual glycyrrhizin, additive potassium loss)
                        
    • 
                        
                        
  • 
                            ●
                            Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
                        
    • 
                        
                        
  • 
                            ●
                            Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)
                        
    • 
                        
                    

                

                

                
                

                    

                        일일 최대 섭취 허용량: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
                    

                

                
            

            

                건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Deglycyrrhizinated Licorice (DGL) help with Peptic Ulcer Disease?
            
        
        

            Based on 2 studies with 150 participants, there is limited but promising evidence that Deglycyrrhizinated Licorice (DGL) may support Peptic Ulcer Disease management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Deglycyrrhizinated Licorice (DGL) should I take for Peptic Ulcer Disease?
            
        
        

            Studies have used various dosages. A commonly studied range is 380-760 mg DGL extract 3 times daily before meals. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Deglycyrrhizinated Licorice (DGL)?
            
        
        

            Reported side effects may include Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Deglycyrrhizinated Licorice (DGL) and Peptic Ulcer Disease?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
관련 다른 성분: Peptic Ulcer Disease

                    

                        
                        
                            Zinc Carnosine
                            B

                        
                        
                    

                

                

                
                

                    
Deglycyrrhizinated Licorice (DGL) 다른 건강 상태에 대한 근거

                    

                        
                        
                            Functional Dyspepsia
                            C

                        
                        
                    

                

                
            

        

        

    


    
    












    

        FDA 면책 조항:
        이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.