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Zinc Carnosine 관련 Peptic Ulcer Disease

B

Reduces NSAID-induced small bowel injury by 70% (measured by calprotectin). Promotes gastric mucosal healing. 75-150 mg/day as zinc carnosine complex.

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            B

        

        

            
결론

            
            
Reduces NSAID-induced small bowel injury by 70% (measured by calprotectin). Promotes gastric mucosal healing. 75-150 mg/day as zinc carnosine complex.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=92
                
                
                
            

            
                Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: A …
            
            

                
                Dose: Zinc carnosine 75 mg twice daily for 10 days
                
                
                vs: Standard triple therapy for 14 days
                
                
                Outcome: H. pylori eradication rate
                
                
                효과: 93.5% vs 69.6%
                
                
                P=0.003
                
            

            
            
대상 집단: Dyspepsia patients with H. pylori infection

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats.
            
            

                
                Dose: 30 mg/kg
                
                
                vs: None
                
                
                Outcome: mineral status
                
                
                효과: or 2
                
                
                None
                
            

            
            
대상 집단: animal model

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
연구

    

    

        
500

        
참여자

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
등급

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: A randomized controlled study.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        World journal of …
                        2022
                        
                        8 인용
                        
                    

                

                
                

                    

                        
                            The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Life sciences
                        1991
                        
                        52 인용
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
일반적으로 사용되는 용량

                

                    
                    

                        
general:

                        
75 mg twice daily (as zinc carnosine complex)

                    

                    
                    

                        
nsaidprotection:

                        
37.5-75 mg twice daily alongside NSAID therapy

                    

                    
                    

                        
gastricprotection:

                        
75 mg twice daily for 8 weeks

                    

                    
                

                
                

                    상한량: 40 mg/day elemental zinc (equivalent to ~340 mg zinc carnosine); risk of copper depletion above this
                

                
            

            

            
            

                
연구에서 사용된 용량

                

                    

                        
                            

                                용량
                                기간
                                효과
                                N
                            

                        
                        
                            
                            

                                Zinc carnosine 75 mg twice daily for 10 days
                                --
                                
                                    
                                    Positive
                                    
                                
                                92
                            

                            
                            

                                30 mg/kg
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                권장 복용 시간: On an empty stomach or between meals for gastric mucosal contact; twice daily
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
보고된 부작용

                    
    
                        
                        
  • 
                            ⚠
                            Nausea (most common, usually transient)
                        
    • 
                        
                        
  • 
                            ⚠
                            Metallic taste
                        
    • 
                        
                        
  • 
                            ⚠
                            Copper depletion with long-term high-dose use (>40 mg elemental zinc/day)
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache
                        
    • 
                        
                    

                

                

                
                

                    
알려진 상호작용

                    
    
                        
                        
  • 
                            ●
                            Tetracycline and quinolone antibiotics (zinc reduces absorption; space 2 hours)
                        
    • 
                        
                        
  • 
                            ●
                            Penicillamine (zinc reduces absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Copper supplements (zinc competes with copper for absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Bisphosphonates (zinc may reduce absorption; space 2 hours)
                        
    • 
                        
                    

                

                

                
                

                    

                        일일 최대 섭취 허용량: 40 mg/day elemental zinc (equivalent to ~340 mg zinc carnosine); risk of copper depletion above this
                    

                

                
            

            

                건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Zinc Carnosine help with Peptic Ulcer Disease?
            
        
        

            Based on 6 studies with 500 participants, there is moderate evidence from clinical studies that Zinc Carnosine may support Peptic Ulcer Disease management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Zinc Carnosine should I take for Peptic Ulcer Disease?
            
        
        

            Studies have used various dosages. A commonly studied range is 75 mg twice daily (as zinc carnosine complex). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Zinc Carnosine?
            
        
        

            Reported side effects may include Nausea (most common, usually transient), Metallic taste, Copper depletion with long-term high-dose use (>40 mg elemental zinc/day), Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Zinc Carnosine and Peptic Ulcer Disease?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
관련 다른 성분: Peptic Ulcer Disease

                    

                        
                        
                            Deglycyrrhizinated Licorice (DGL)
                            C

                        
                        
                    

                

                

                
                

                    
Zinc Carnosine 다른 건강 상태에 대한 근거

                    

                        
                        
                            Increased Intestinal Permeability (Leaky Gut)
                            C

                        
                        
                    

                

                
            

        

        

    


    
    












    

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        이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.