Deglycyrrhizinated Licorice (DGL) para Peptic Ulcer Disease

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'gutcited.com'; const params = 'ingredient\u003Ddeglycyrrhizinated\u002Dlicorice\u0026condition\u003Dgastric\u002Dulcer'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Conclusión

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

Key Study Findings

Systematic Review

Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.

Dose: None vs: None Outcome: None Efecto: None None

Población: the presence of dyspepsia in the absence of organic or metabolic causes

In Vitro

Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive …

Dose: Glycyrrhiza glabra flavonoid-rich extract vs: None Outcome: compatibility with probiotics and digestive enzymes Efecto: compatible with all tested strains None

Población: Probiotic strains and enzymes (in vitro)

Review

Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence …

Dose: None vs: None Outcome: None Efecto: None None

Población: IBD patients (herbal therapy review)

Randomized Controlled Trial 4 weeks Double-blind

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled …

Dose: 75 mg twice daily vs: Placebo Outcome: Functional dyspepsia symptom severity (SFLDQ) Efecto: None None

Población: Adults with functional dyspepsia

Key Statistics

Estudios

150

Participantes

↑

Positive

Calificación

Referenced Papers

Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review. Systematic Review

Current drug discovery … 2021 16 citas

Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes. Other

Journal of dietary … 2017 13 citas

Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies. Review

Annals of gastroenterology 2016 41 citas

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Other

Evidence-based complementary and … 2012 70 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 380-760 mg DGL extract 3 times daily before meals
gastricsupport:: 760 mg before meals and at bedtime
dyspepsiasupport:: 380-400 mg chewable tablet 20 minutes before meals, 3 times daily

Límite superior: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Positive	--
Glycyrrhiza glabra flavonoid-rich extract	--	Positive	--
None	--	Mixed	--
75 mg twice daily	4 weeks	Positive	--

Mejor momento para tomar: 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact

Safety & Side Effects

Efectos secundarios reportados

⚠ Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
⚠ Mild nausea in rare cases
⚠ Headache (uncommon)
⚠ If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)

Interacciones conocidas

● Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
● Diuretics (if residual glycyrrhizin, additive potassium loss)
● Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
● Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)

Ingesta máxima tolerable: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Deglycyrrhizinated Licorice (DGL) help with Peptic Ulcer Disease?

Based on 2 studies with 150 participants, there is limited but promising evidence that Deglycyrrhizinated Licorice (DGL) may support Peptic Ulcer Disease management. Our evidence grade is C (Some Evidence).

How much Deglycyrrhizinated Licorice (DGL) should I take for Peptic Ulcer Disease?

Studies have used various dosages. A commonly studied range is 380-760 mg DGL extract 3 times daily before meals. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Deglycyrrhizinated Licorice (DGL)?

Reported side effects may include Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Deglycyrrhizinated Licorice (DGL) and Peptic Ulcer Disease?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Related Evidence

Otros ingredientes para Peptic Ulcer Disease

Zinc Carnosine B

Deglycyrrhizinated Licorice (DGL) para otras condiciones

Functional Dyspepsia C

Veredicto rápido

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

Evidence Strength52%

Moderate confidence

Desglose de estudios

RCT (0)Meta (0)Other (2)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Peptic Ulcer Disease

Más información

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.