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Deglycyrrhizinated Licorice (DGL) para Peptic Ulcer Disease

C

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

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            C

        

        

            
Conclusão

            
            
Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Systematic Review
                
                
                
                
            

            
                Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Efeito: None
                
                
                None
                
            

            
            
População: the presence of dyspepsia in the absence of organic or metabolic causes

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive …
            
            

                
                Dose: Glycyrrhiza glabra flavonoid-rich extract
                
                
                vs: None
                
                
                Outcome: compatibility with probiotics and digestive enzymes
                
                
                Efeito: compatible with all tested strains
                
                
                None
                
            

            
            
População: Probiotic strains and enzymes (in vitro)

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence …
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Efeito: None
                
                
                None
                
            

            
            
População: IBD patients (herbal therapy review)

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                4 weeks
                
                
                Double-blind
                
            

            
                An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled …
            
            

                
                Dose: 75 mg twice daily
                
                
                vs: Placebo
                
                
                Outcome: Functional dyspepsia symptom severity (SFLDQ)
                
                
                Efeito: None
                
                
                None
                
            

            
            
População: Adults with functional dyspepsia

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
2

        
Estudos

    

    

        
150

        
Participantes

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Nota

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.
                        
                        
                            
                                Systematic Review
                            
                            
                            
                        
                    

                    

                        Current drug discovery …
                        2021
                        
                        16 citações
                        
                    

                

                
                

                    

                        
                            Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of dietary …
                        2017
                        
                        13 citações
                        
                    

                

                
                

                    

                        
                            Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Annals of gastroenterology
                        2016
                        
                        41 citações
                        
                    

                

                
                

                    

                        
                            An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Evidence-based complementary and …
                        2012
                        
                        70 citações
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosagens Comumente Utilizadas

                

                    
                    

                        
general:

                        
380-760 mg DGL extract 3 times daily before meals

                    

                    
                    

                        
gastricsupport:

                        
760 mg before meals and at bedtime

                    

                    
                    

                        
dyspepsiasupport:

                        
380-400 mg chewable tablet 20 minutes before meals, 3 times daily

                    

                    
                

                
                

                    Limite superior: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
                

                
            

            

            
            

                
Dosagens Estudadas em Pesquisas

                

                    

                        
                            

                                Dosagem
                                Duração
                                Efeito
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                Glycyrrhiza glabra flavonoid-rich extract
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                75 mg twice daily
                                4 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Melhor horário: 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Efeitos Colaterais Relatados

                    
    
                        
                        
  • 
                            ⚠
                            Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild nausea in rare cases
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache (uncommon)
                        
    • 
                        
                        
  • 
                            ⚠
                            If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)
                        
    • 
                        
                    

                

                

                
                

                    
Interações Conhecidas

                    
    
                        
                        
  • 
                            ●
                            Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
                        
    • 
                        
                        
  • 
                            ●
                            Diuretics (if residual glycyrrhizin, additive potassium loss)
                        
    • 
                        
                        
  • 
                            ●
                            Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
                        
    • 
                        
                        
  • 
                            ●
                            Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)
                        
    • 
                        
                    

                

                

                
                

                    

                        Ingestão máxima tolerável: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
                    

                

                
            

            

                Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Deglycyrrhizinated Licorice (DGL) help with Peptic Ulcer Disease?
            
        
        

            Based on 2 studies with 150 participants, there is limited but promising evidence that Deglycyrrhizinated Licorice (DGL) may support Peptic Ulcer Disease management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Deglycyrrhizinated Licorice (DGL) should I take for Peptic Ulcer Disease?
            
        
        

            Studies have used various dosages. A commonly studied range is 380-760 mg DGL extract 3 times daily before meals. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Deglycyrrhizinated Licorice (DGL)?
            
        
        

            Reported side effects may include Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Deglycyrrhizinated Licorice (DGL) and Peptic Ulcer Disease?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Outros ingredientes para Peptic Ulcer Disease

                    

                        
                        
                            Zinc Carnosine
                            B

                        
                        
                    

                

                

                
                

                    
Deglycyrrhizinated Licorice (DGL) para outras condições

                    

                        
                        
                            Functional Dyspepsia
                            C

                        
                        
                    

                

                
            

        

        

    


    
    












    

        Aviso Legal da FDA:
        Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.