Deglycyrrhizinated Licorice (DGL) для Peptic Ulcer Disease

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

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Итог

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

Key Study Findings

Systematic Review

Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.

Dose: None или: None Outcome: None Эффект: None None

Популяция: the presence of dyspepsia in the absence of organic or metabolic causes

In Vitro

Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive …

Dose: Glycyrrhiza glabra flavonoid-rich extract или: None Outcome: compatibility with probiotics and digestive enzymes Эффект: compatible with all tested strains None

Популяция: Probiotic strains and enzymes (in vitro)

Review

Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence …

Dose: None или: None Outcome: None Эффект: None None

Популяция: IBD patients (herbal therapy review)

Randomized Controlled Trial 4 weeks Double-blind

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled …

Dose: 75 mg twice daily или: Placebo Outcome: Functional dyspepsia symptom severity (SFLDQ) Эффект: None None

Популяция: Adults with functional dyspepsia

Key Statistics

Исследования

150

Участники

↑

Positive

Оценка

Referenced Papers

Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review. Systematic Review

Current drug discovery … 2021 16 цитирований

Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes. Other

Journal of dietary … 2017 13 цитирований

Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies. Review

Annals of gastroenterology 2016 41 цитирований

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Other

Evidence-based complementary and … 2012 70 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:: 380-760 mg DGL extract 3 times daily before meals
gastricsupport:: 760 mg before meals and at bedtime
dyspepsiasupport:: 380-400 mg chewable tablet 20 minutes before meals, 3 times daily

Верхний предел: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
None	--	Positive	--
Glycyrrhiza glabra flavonoid-rich extract	--	Positive	--
None	--	Mixed	--
75 mg twice daily	4 weeks	Positive	--

Лучшее время приёма: 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
⚠ Mild nausea in rare cases
⚠ Headache (uncommon)
⚠ If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)

Известные взаимодействия

● Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
● Diuretics (if residual glycyrrhizin, additive potassium loss)
● Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
● Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)

Допустимый верхний уровень потребления: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Deglycyrrhizinated Licorice (DGL) help with Peptic Ulcer Disease?

Based on 2 studies with 150 participants, there is limited but promising evidence that Deglycyrrhizinated Licorice (DGL) may support Peptic Ulcer Disease management. Our evidence grade is C (Some Evidence).

How much Deglycyrrhizinated Licorice (DGL) should I take for Peptic Ulcer Disease?

Studies have used various dosages. A commonly studied range is 380-760 mg DGL extract 3 times daily before meals. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Deglycyrrhizinated Licorice (DGL)?

Reported side effects may include Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Deglycyrrhizinated Licorice (DGL) and Peptic Ulcer Disease?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Related Evidence

Другие ингредиенты для Peptic Ulcer Disease

Zinc Carnosine B

Deglycyrrhizinated Licorice (DGL) для других состояний

Functional Dyspepsia C

Краткий вывод

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

Evidence Strength52%

Moderate confidence

Разбор исследований

RCT (0)Meta (0)Other (2)

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