Deglycyrrhizinated Licorice (DGL) 用于 消化性溃疡病
C 证据 来自小型研究的证据有限，但存在一些积极信号。Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.
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C
结论
Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.
Key Study Findings
Systematic Review
Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: the presence of dyspepsia in the absence of organic or metabolic causes
In Vitro
Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive …
Dose: Glycyrrhiza glabra flavonoid-rich extract
vs: None
Outcome: compatibility with probiotics and digestive enzymes
效果: compatible with all tested strains
None
研究人群: Probiotic strains and enzymes (in vitro)
Review
Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: IBD patients (herbal therapy review)
Randomized Controlled Trial
4 weeks
Double-blind
An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled …
Dose: 75 mg twice daily
vs: Placebo
Outcome: Functional dyspepsia symptom severity (SFLDQ)
效果: None
None
研究人群: Adults with functional dyspepsia
Key Statistics
2
研究数量
150
受试者
↑
Positive
C
等级
Referenced Papers
Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.
Systematic Review
Current drug discovery …
2021
16 次引用
Journal of dietary …
2017
13 次引用
Annals of gastroenterology
2016
41 次引用
Evidence-based complementary and …
2012
70 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 380-760 mg DGL extract 3 times daily before meals
- gastricsupport:
- 760 mg before meals and at bedtime
- dyspepsiasupport:
- 380-400 mg chewable tablet 20 minutes before meals, 3 times daily
上限： Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| Glycyrrhiza glabra flavonoid-rich extract | -- | Positive | -- |
| None | -- | Mixed | -- |
| 75 mg twice daily | 4 weeks | Positive | -- |
最佳服用时间： 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact
Safety & Side Effects
已报告的副作用
- ⚠ Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
- ⚠ Mild nausea in rare cases
- ⚠ Headache (uncommon)
- ⚠ If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)
已知相互作用
- ● Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
- ● Diuretics (if residual glycyrrhizin, additive potassium loss)
- ● Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
- ● Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)
可耐受最高摄入量： Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Deglycyrrhizinated Licorice (DGL) help with 消化性溃疡病?
Based on 2 studies with 150 participants, there is limited but promising evidence that Deglycyrrhizinated Licorice (DGL) may support 消化性溃疡病 management. Our evidence grade is C (Some Evidence).
How much Deglycyrrhizinated Licorice (DGL) should I take for 消化性溃疡病?
Studies have used various dosages. A commonly studied range is 380-760 mg DGL extract 3 times daily before meals. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Deglycyrrhizinated Licorice (DGL)?
Reported side effects may include Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Deglycyrrhizinated Licorice (DGL) and 消化性溃疡病?
We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 消化性溃疡病
Deglycyrrhizinated Licorice (DGL) 用于其他健康状况
References
- [1] Maryam Azimi et al.. Curr Drug Discov Technol. 2021. Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review. doi:10.2174/1570163817666200611132831 PubMed
- [2] Mannanthendil Kumaran Asha et al.. J Diet Suppl. 2017. Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes. doi:10.1080/19390211.2016.1223257 PubMed
- [3] John K Triantafillidis et al.. Ann Gastroenterol. 2016. Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies. doi:10.20524/aog.2016.0059 PubMed
- [4] Kadur Ramamurthy Raveendra et al.. Evid Based Complement Alternat Med. 2012. An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. doi:10.1155/2012/216970 PubMed
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