Deglycyrrhizinated Licorice (DGL) per Peptic Ulcer Disease

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

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In sintesi

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

Key Study Findings

Systematic Review

Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: the presence of dyspepsia in the absence of organic or metabolic causes

In Vitro

Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive …

Dose: Glycyrrhiza glabra flavonoid-rich extract vs: None Outcome: compatibility with probiotics and digestive enzymes Effetto: compatible with all tested strains None

Popolazione: Probiotic strains and enzymes (in vitro)

Review

Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence …

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: IBD patients (herbal therapy review)

Randomized Controlled Trial 4 weeks Double-blind

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled …

Dose: 75 mg twice daily vs: Placebo Outcome: Functional dyspepsia symptom severity (SFLDQ) Effetto: None None

Popolazione: Adults with functional dyspepsia

Key Statistics

Studi

150

Partecipanti

↑

Positive

Grado

Referenced Papers

Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review. Systematic Review

Current drug discovery … 2021 16 citazioni

Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes. Other

Journal of dietary … 2017 13 citazioni

Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies. Review

Annals of gastroenterology 2016 41 citazioni

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Other

Evidence-based complementary and … 2012 70 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 380-760 mg DGL extract 3 times daily before meals
gastricsupport:: 760 mg before meals and at bedtime
dyspepsiasupport:: 380-400 mg chewable tablet 20 minutes before meals, 3 times daily

Limite massimo: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Positive	--
Glycyrrhiza glabra flavonoid-rich extract	--	Positive	--
None	--	Mixed	--
75 mg twice daily	4 weeks	Positive	--

Momento migliore per l'assunzione: 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact

Safety & Side Effects

Effetti collaterali segnalati

⚠ Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
⚠ Mild nausea in rare cases
⚠ Headache (uncommon)
⚠ If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)

Interazioni note

● Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
● Diuretics (if residual glycyrrhizin, additive potassium loss)
● Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
● Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)

Livello di assunzione massimo tollerabile: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Deglycyrrhizinated Licorice (DGL) help with Peptic Ulcer Disease?

Based on 2 studies with 150 participants, there is limited but promising evidence that Deglycyrrhizinated Licorice (DGL) may support Peptic Ulcer Disease management. Our evidence grade is C (Some Evidence).

How much Deglycyrrhizinated Licorice (DGL) should I take for Peptic Ulcer Disease?

Studies have used various dosages. A commonly studied range is 380-760 mg DGL extract 3 times daily before meals. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Deglycyrrhizinated Licorice (DGL)?

Reported side effects may include Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Deglycyrrhizinated Licorice (DGL) and Peptic Ulcer Disease?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Peptic Ulcer Disease

Zinc Carnosine B

Deglycyrrhizinated Licorice (DGL) per altre condizioni

Functional Dyspepsia C

Verdetto rapido

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

Evidence Strength52%

Moderate confidence

Analisi degli studi

RCT (0)Meta (0)Other (2)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Peptic Ulcer Disease

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.