Deglycyrrhizinated Licorice (DGL) untuk Peptic Ulcer Disease

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

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Kesimpulan

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

Key Study Findings

Systematic Review

Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.

Dose: None vs: None Outcome: None Efek: None None

Populasi: the presence of dyspepsia in the absence of organic or metabolic causes

In Vitro

Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive …

Dose: Glycyrrhiza glabra flavonoid-rich extract vs: None Outcome: compatibility with probiotics and digestive enzymes Efek: compatible with all tested strains None

Populasi: Probiotic strains and enzymes (in vitro)

Review

Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence …

Dose: None vs: None Outcome: None Efek: None None

Populasi: IBD patients (herbal therapy review)

Randomized Controlled Trial 4 weeks Double-blind

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled …

Dose: 75 mg twice daily vs: Placebo Outcome: Functional dyspepsia symptom severity (SFLDQ) Efek: None None

Populasi: Adults with functional dyspepsia

Key Statistics

Studi

150

Peserta

↑

Positive

Peringkat

Referenced Papers

Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review. Systematic Review

Current drug discovery … 2021 16 sitasi

Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes. Other

Journal of dietary … 2017 13 sitasi

Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies. Review

Annals of gastroenterology 2016 41 sitasi

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Other

Evidence-based complementary and … 2012 70 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 380-760 mg DGL extract 3 times daily before meals
gastricsupport:: 760 mg before meals and at bedtime
dyspepsiasupport:: 380-400 mg chewable tablet 20 minutes before meals, 3 times daily

Batas atas: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Positive	--
Glycyrrhiza glabra flavonoid-rich extract	--	Positive	--
None	--	Mixed	--
75 mg twice daily	4 weeks	Positive	--

Waktu terbaik diminum: 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
⚠ Mild nausea in rare cases
⚠ Headache (uncommon)
⚠ If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)

Interaksi yang Diketahui

● Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
● Diuretics (if residual glycyrrhizin, additive potassium loss)
● Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
● Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)

Asupan atas yang dapat ditoleransi: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Deglycyrrhizinated Licorice (DGL) help with Peptic Ulcer Disease?

Based on 2 studies with 150 participants, there is limited but promising evidence that Deglycyrrhizinated Licorice (DGL) may support Peptic Ulcer Disease management. Our evidence grade is C (Some Evidence).

How much Deglycyrrhizinated Licorice (DGL) should I take for Peptic Ulcer Disease?

Studies have used various dosages. A commonly studied range is 380-760 mg DGL extract 3 times daily before meals. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Deglycyrrhizinated Licorice (DGL)?

Reported side effects may include Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Deglycyrrhizinated Licorice (DGL) and Peptic Ulcer Disease?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Peptic Ulcer Disease

Zinc Carnosine B

Deglycyrrhizinated Licorice (DGL) untuk kondisi lain

Functional Dyspepsia C

Kesimpulan Singkat

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

Evidence Strength52%

Moderate confidence

Rincian Studi

RCT (0)Meta (0)Other (2)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Peptic Ulcer Disease

Pelajari Lebih Lanjut

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