알파-갈락토시다아제 관련 과민성 대장 증후군(IBS)
D 연구 예비 연구(실험실 연구, 증례 보고)만 존재합니다.고포드맵 식이를 섭취하는 IBS 환자 대상 단일 연구입니다. 특정 식품 유발요인으로 인한 가스 관련 증상을 줄일 수 있습니다.
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D
결론
고포드맵 식이를 섭취하는 IBS 환자 대상 단일 연구입니다. 특정 식품 유발요인으로 인한 가스 관련 증상을 줄일 수 있습니다.
Key Study Findings
Review
Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: None
Randomized Controlled Trial
Double-blind
A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal …
Dose: 1200 G
vs: placebo
Outcome: every 30 min during 7
효과: None
None
대상 집단: patients with ibs after three standardized
Randomized Controlled Trial
n=31
2.0 weeks
Double-blind
Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.
Dose: 300 GALU or 150 GALU
vs: Placebo (glucose)
Outcome: GI symptom severity on VAS
효과: None
pP0.006
대상 집단: IBS patients (Rome III, H2 producers)
Randomized Controlled Trial
n=125
4 weeks
Double-blind
Does oral α-galactosidase relieve irritable bowel symptoms?
Dose: alpha-galactosidase 600 GalU per meal
vs: placebo
Outcome: overall IBS symptom relief
효과: no significant difference vs placebo
>0.05
대상 집단: IBS patients
Key Statistics
1
연구
60
참여자
↑
Positive
D
등급
Referenced Papers
International journal of …
2021
16 인용
Neurogastroenterology and motility
2021
4 인용
The American journal …
2018
49 인용
Scandinavian journal of …
2016
17 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods
- standardbeanodose:
- 300 GalU (2-3 tablets) with first bite of problem food
상한량: No established upper limit; adjust per meal as needed
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| 1200 G | -- | Neutral | -- |
| 300 GALU or 150 GALU | 2.0 weeks | Positive | 31 |
| alpha-galactosidase 600 GalU per meal | 4 weeks | Neutral | 125 |
권장 복용 시간: With the first bite of gas-producing food
Safety & Side Effects
보고된 부작용
- ⚠ Generally very well-tolerated
- ⚠ Rare allergic reactions to mold-derived enzyme (Aspergillus source)
- ⚠ May cause mild GI discomfort in rare cases
알려진 상호작용
- ● Acarbose (alpha-galactosidase may counteract the blood sugar-lowering mechanism of acarbose; contraindicated for concurrent use)
- ● Miglitol (similar mechanism conflict as acarbose)
일일 최대 섭취 허용량: No established upper limit; adjust per meal as needed
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does 알파-갈락토시다아제 help with 과민성 대장 증후군(IBS)?
Based on 1 studies with 60 participants, there is preliminary evidence that needs more research that 알파-갈락토시다아제 may support 과민성 대장 증후군(IBS) management. Our evidence grade is D (Very Early Research).
How much 알파-갈락토시다아제 should I take for 과민성 대장 증후군(IBS)?
Studies have used various dosages. A commonly studied range is 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 알파-갈락토시다아제?
Reported side effects may include Generally very well-tolerated, Rare allergic reactions to mold-derived enzyme (Aspergillus source), May cause mild GI discomfort in rare cases. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 알파-갈락토시다아제 and 과민성 대장 증후군(IBS)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 60 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: 과민성 대장 증후군(IBS)
알파-갈락토시다아제 다른 건강 상태에 대한 근거
References
- [1] Fabio Caputo et al.. Int J Environ Res Public Health. 2021. Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review. doi:10.3390/ijerph18063320 PubMed
- [2] Lena Böhn et al.. Neurogastroenterol Motil. 2021. A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome … doi:10.1111/nmo.14094 PubMed
- [3] C J Tuck et al.. Am J Gastroenterol. 2018. Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. doi:10.1038/ajg.2017.245 PubMed
- [4] Markku Hillilä et al.. Scand J Gastroenterol. 2016. Does oral α-galactosidase relieve irritable bowel symptoms? doi:10.3109/00365521.2015.1063156 PubMed
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