Alpha-Galactosidase 관련 Bloating and Intestinal Gas

Reduces gas symptoms from high-fiber foods containing raffinose/stachyose by 50-70%. Beano (alpha-galactosidase 300 GalU) is the most studied formulation.

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결론

Reduces gas symptoms from high-fiber foods containing raffinose/stachyose by 50-70%. Beano (alpha-galactosidase 300 GalU) is the most studied formulation.

Key Study Findings

Review

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.

Dose: None vs: None Outcome: None 효과: None None

대상 집단: None

Randomized Controlled Trial Double-blind

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal …

Dose: 1200 G vs: placebo Outcome: every 30 min during 7 효과: None None

대상 집단: patients with ibs after three standardized

Other n=17

FABry Disease Patient-Reported Outcome-GastroIntestinal (FABPRO-GI): A new Fabry disease-specific gastrointestinal outcomes instrument.

Dose: None vs: no treatment Outcome: None 효과: None None

대상 집단: fabry disease but are often nonspecific

Randomized Controlled Trial n=31 2.0 weeks Double-blind

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.

Dose: 300 GALU or 150 GALU vs: Placebo (glucose) Outcome: GI symptom severity on VAS 효과: None pP0.006

대상 집단: IBS patients (Rome III, H2 producers)

Randomized Controlled Trial n=125 4 weeks Double-blind

Does oral α-galactosidase relieve irritable bowel symptoms?

Dose: alpha-galactosidase 600 GalU per meal vs: placebo Outcome: overall IBS symptom relief 효과: no significant difference vs placebo >0.05

대상 집단: IBS patients

Case Reports

A family with various symptomatology suggestive of Anderson-Fabry disease and a genetic polymorphism of alpha …

Dose: 3.7nmol/mL/h vs: None Outcome: None 효과: None None

대상 집단: patients

Key Statistics

연구

300

참여자

↑

Positive

등급

Referenced Papers

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review. Review

International journal of … 2021 16 인용

FABry Disease Patient-Reported Outcome-GastroIntestinal (FABPRO-GI): A new Fabry disease-specific gastrointestinal outcomes instrument. Other

Quality of life … 2021 14 인용

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome … RCT

Neurogastroenterology and motility 2021 4 인용

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. RCT

The American journal … 2018 49 인용

Does oral α-galactosidase relieve irritable bowel symptoms? RCT

Scandinavian journal of … 2016 17 인용

A family with various symptomatology suggestive of Anderson-Fabry disease and a genetic polymorphism of alpha galactosidase A gene. Case Report

Clinical biochemistry 2015 18 인용

Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trial. RCT

BMC gastroenterology 2013 12 인용

The effect of oral alpha-galactosidase on intestinal gas production and gas-related symptoms. RCT

Digestive diseases and … 2007 45 인용

Gastrointestinal manifestations of Fabry disease: clinical response to enzyme replacement therapy. Other

Molecular genetics and … 2005 84 인용

Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance. RCT

The Journal of … 1994

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

general:: 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods
standardbeanodose:: 300 GalU (2-3 tablets) with first bite of problem food

상한량: No established upper limit; adjust per meal as needed

연구에서 사용된 용량

용량	기간	효과	N
None	--	Mixed	--
1200 G	--	Neutral	--
None	--	Positive	17
300 GALU or 150 GALU	2.0 weeks	Positive	31
alpha-galactosidase 600 GalU per meal	4 weeks	Neutral	125
3.7nmol/mL/h	--	Mixed	--
None	2 weeks	Positive	--
300 or 1200 GalU	--	Positive	8

권장 복용 시간: With the first bite of gas-producing food

Safety & Side Effects

보고된 부작용

⚠ Generally very well-tolerated
⚠ Rare allergic reactions to mold-derived enzyme (Aspergillus source)
⚠ May cause mild GI discomfort in rare cases

알려진 상호작용

● Acarbose (alpha-galactosidase may counteract the blood sugar-lowering mechanism of acarbose; contraindicated for concurrent use)
● Miglitol (similar mechanism conflict as acarbose)

일일 최대 섭취 허용량: No established upper limit; adjust per meal as needed

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does Alpha-Galactosidase help with Bloating and Intestinal Gas?

Based on 4 studies with 300 participants, there is moderate evidence from clinical studies that Alpha-Galactosidase may support Bloating and Intestinal Gas management. Our evidence grade is B (Good Evidence).

How much Alpha-Galactosidase should I take for Bloating and Intestinal Gas?

Studies have used various dosages. A commonly studied range is 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Galactosidase?

Reported side effects may include Generally very well-tolerated, Rare allergic reactions to mold-derived enzyme (Aspergillus source), May cause mild GI discomfort in rare cases. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Galactosidase and Bloating and Intestinal Gas?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

Alpha-Galactosidase 다른 건강 상태에 대한 근거

Irritable Bowel Syndrome (IBS) D

한눈에 보기

Reduces gas symptoms from high-fiber foods containing raffinose/stachyose by 50-70%. Beano (alpha-galactosidase 300 GalU) is the most studied formulation.

Evidence Strength72%

High confidence

연구 분석

RCT (6)Meta (0)Other (0)

대안 비교

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모든 성분 보기: Bloating and Intestinal Gas

자세히 알아보기

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.

Alpha-Galactosidase 관련 Bloating and Intestinal Gas

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결론

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

일반적으로 사용되는 용량

연구에서 사용된 용량

Safety & Side Effects

보고된 부작용

알려진 상호작용

Frequently Asked Questions

Related Evidence

관련 다른 성분: Bloating and Intestinal Gas

Alpha-Galactosidase 다른 건강 상태에 대한 근거