Alpha-Galactosidase لـ Irritable Bowel Syndrome (IBS)

D الأبحاث توجد أبحاث أولية فحسب (دراسات مختبرية، تقارير حالات).

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

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الخلاصة

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

Key Study Findings

Review

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: None

Randomized Controlled Trial Double-blind

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal …

Dose: 1200 G مقابل: placebo Outcome: every 30 min during 7 التأثير: None None

المجتمع المدروس: patients with ibs after three standardized

Randomized Controlled Trial n=31 2.0 weeks Double-blind

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.

Dose: 300 GALU or 150 GALU مقابل: Placebo (glucose) Outcome: GI symptom severity on VAS التأثير: None pP0.006

المجتمع المدروس: IBS patients (Rome III, H2 producers)

Randomized Controlled Trial n=125 4 weeks Double-blind

Does oral α-galactosidase relieve irritable bowel symptoms?

Dose: alpha-galactosidase 600 GalU per meal مقابل: placebo Outcome: overall IBS symptom relief التأثير: no significant difference vs placebo >0.05

المجتمع المدروس: IBS patients

Key Statistics

الدراسات

المشاركون

↑

Positive

التقييم

Referenced Papers

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review. Review

International journal of … 2021 16 اقتباسات

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome … RCT

Neurogastroenterology and motility 2021 4 اقتباسات

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. RCT

The American journal … 2018 49 اقتباسات

Does oral α-galactosidase relieve irritable bowel symptoms? RCT

Scandinavian journal of … 2016 17 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods
standardbeanodose:: 300 GalU (2-3 tablets) with first bite of problem food

الحد الأعلى: No established upper limit; adjust per meal as needed

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Mixed	--
1200 G	--	Neutral	--
300 GALU or 150 GALU	2.0 weeks	Positive	31
alpha-galactosidase 600 GalU per meal	4 weeks	Neutral	125

أفضل وقت للتناول: With the first bite of gas-producing food

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Generally very well-tolerated
⚠ Rare allergic reactions to mold-derived enzyme (Aspergillus source)
⚠ May cause mild GI discomfort in rare cases

التفاعلات المعروفة

● Acarbose (alpha-galactosidase may counteract the blood sugar-lowering mechanism of acarbose; contraindicated for concurrent use)
● Miglitol (similar mechanism conflict as acarbose)

الحد الأقصى المسموح به: No established upper limit; adjust per meal as needed

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Alpha-Galactosidase help with Irritable Bowel Syndrome (IBS)?

Based on 1 studies with 60 participants, there is preliminary evidence that needs more research that Alpha-Galactosidase may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is D (Very Early Research).

How much Alpha-Galactosidase should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Galactosidase?

Reported side effects may include Generally very well-tolerated, Rare allergic reactions to mold-derived enzyme (Aspergillus source), May cause mild GI discomfort in rare cases. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Galactosidase and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 60 total participants. The overall direction of effect is positive.

مكونات أخرى لـ Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

Alpha-Galactosidase لحالات أخرى

Bloating and Intestinal Gas B

الخلاصة السريعة

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

Evidence Strength30%

Low confidence

تفصيل الدراسات

RCT (3)Meta (0)Other (0)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Irritable Bowel Syndrome (IBS)

اعرف المزيد

References

[1] Fabio Caputo et al.. Int J Environ Res Public Health. 2021. Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review. doi:10.3390/ijerph18063320 PubMed
[2] Lena Böhn et al.. Neurogastroenterol Motil. 2021. A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome … doi:10.1111/nmo.14094 PubMed
[3] C J Tuck et al.. Am J Gastroenterol. 2018. Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. doi:10.1038/ajg.2017.245 PubMed
[4] Markku Hillilä et al.. Scand J Gastroenterol. 2016. Does oral α-galactosidase relieve irritable bowel symptoms? doi:10.3109/00365521.2015.1063156 PubMed

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Alpha-Galactosidase لـ Irritable Bowel Syndrome (IBS)

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الخلاصة

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

الجرعات الشائعة

الجرعات المدروسة في الأبحاث

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

التفاعلات المعروفة

Frequently Asked Questions

Related Evidence

مكونات أخرى لـ Irritable Bowel Syndrome (IBS)

Alpha-Galactosidase لحالات أخرى

References