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비피도박테리움 롱검 관련 과민성 대장 증후군(IBS)

B 근거 적어도 하나의 무작위 시험이 이를 지지하며, 대체로 일관된 결과를 보입니다.

RCT에서 위약 대비 IBS 복합 증상 점수가 유의하게 감소한 것으로 나타났습니다. 팽만감과 복부 팽창에 특히 유익하며 알플로렉스/얼라인으로 판매됩니다.

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결론

RCT에서 위약 대비 IBS 복합 증상 점수가 유의하게 감소한 것으로 나타났습니다. 팽만감과 복부 팽창에 특히 유익하며 알플로렉스/얼라인으로 판매됩니다.

Key Study Findings

Meta-Analysis n=3154
Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …
Dose: None vs: placebo Outcome: quality of life, depression, and anxiety in IBS … 효과: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression) None

대상 집단: patients with irritable bowel syndrome

Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None vs: placebo Outcome: improvement in key IBS symptoms 효과: None None

대상 집단: patients with IBS from 32 RCTs evaluating 10 probiotic strains

Controlled Clinical Trial n=51 12 weeks Open-label
Targeted probiotic therapy in irritable bowel syndrome: a clinical evaluation on Clostridium butyricum CBM588 and …
Dose: None vs: Pre-treatment baseline Outcome: IBS-SSS score reduction 효과: None None

대상 집단: IBS-D and IBS-C patients

Observational Study n=37 8 weeks Open-label
An 8-Week Course of Bifidobacterium longum 35624® Is Associated with a Reduction in the Symptoms …
Dose: None vs: None Outcome: Total IBS symptom score (TISS) 효과: 43.4% TISS reduction; >60% >=30% responders None

대상 집단: Adults with IBS (Rome IV criteria)

In Vitro n=35
A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum …
Dose: 1e6 CFU/mL vs: IBS supernatants without probiotic Outcome: Caco-2 paracellular permeability 효과: None <0.001

대상 집단: IBS patients (28) and asymptomatic controls (7)

Review
The Role and the Regulation of NLRP3 Inflammasome in Irritable Bowel Syndrome: A Narrative Review.
Dose: None vs: None Outcome: IBS symptom management via NLRP3 inhibition 효과: None None

대상 집단: Patients with IBS (narrative review)

Key Statistics

4

연구

600

참여자

↑

Positive

B

등급

Referenced Papers

The Cochrane database … 2020 14 인용
Journal of gastroenterology … 2017 32 인용

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

general:
1-10 billion CFU/day
ibssupport:
1 billion CFU/day (35624 strain, marketed as Alflorex/Align)

상한량: Well-tolerated up to 10 billion CFU/day in clinical trials

연구에서 사용된 용량

용량 기간 효과 N
None -- Positive 3154
None -- Positive --
None 12 weeks Positive 51
None 8 weeks Positive 37
1e6 CFU/mL -- Positive 35
None -- Positive --
None 12 weeks Positive --
1x10^10 CFU daily 6 weeks Positive 35

권장 복용 시간: On an empty stomach or before meals

Safety & Side Effects

보고된 부작용

  • ⚠ Mild gas and bloating during initial use
  • ⚠ Occasional abdominal discomfort
  • ⚠ Rare loose stools
  • ⚠ Very rare: bacteremia in immunocompromised individuals

알려진 상호작용

  • ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
  • ● Immunosuppressants (use with caution in immunocompromised patients)

일일 최대 섭취 허용량: Well-tolerated up to 10 billion CFU/day in clinical trials

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does 비피도박테리움 롱검 help with 과민성 대장 증후군(IBS)?
Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that 비피도박테리움 롱검 may support 과민성 대장 증후군(IBS) management. Our evidence grade is B (Good Evidence).
How much 비피도박테리움 롱검 should I take for 과민성 대장 증후군(IBS)?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 비피도박테리움 롱검?
Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 비피도박테리움 롱검 and 과민성 대장 증후군(IBS)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

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