Alpha-Galactosidase 用于 Irritable Bowel Syndrome (IBS)

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

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结论

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

Key Study Findings

Review

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Randomized Controlled Trial Double-blind

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal …

Dose: 1200 G vs: placebo Outcome: every 30 min during 7 效果: None None

研究人群: patients with ibs after three standardized

Randomized Controlled Trial n=31 2.0 weeks Double-blind

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.

Dose: 300 GALU or 150 GALU vs: Placebo (glucose) Outcome: GI symptom severity on VAS 效果: None pP0.006

研究人群: IBS patients (Rome III, H2 producers)

Randomized Controlled Trial n=125 4 weeks Double-blind

Does oral α-galactosidase relieve irritable bowel symptoms?

Dose: alpha-galactosidase 600 GalU per meal vs: placebo Outcome: overall IBS symptom relief 效果: no significant difference vs placebo >0.05

研究人群: IBS patients

Key Statistics

研究数量

受试者

↑

Positive

等级

Referenced Papers

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review. Review

International journal of … 2021 16 次引用

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome … RCT

Neurogastroenterology and motility 2021 4 次引用

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. RCT

The American journal … 2018 49 次引用

Does oral α-galactosidase relieve irritable bowel symptoms? RCT

Scandinavian journal of … 2016 17 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods
standardbeanodose:: 300 GalU (2-3 tablets) with first bite of problem food

上限： No established upper limit; adjust per meal as needed

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Mixed	--
1200 G	--	Neutral	--
300 GALU or 150 GALU	2.0 weeks	Positive	31
alpha-galactosidase 600 GalU per meal	4 weeks	Neutral	125

最佳服用时间： With the first bite of gas-producing food

Safety & Side Effects

已报告的副作用

⚠ Generally very well-tolerated
⚠ Rare allergic reactions to mold-derived enzyme (Aspergillus source)
⚠ May cause mild GI discomfort in rare cases

已知相互作用

● Acarbose (alpha-galactosidase may counteract the blood sugar-lowering mechanism of acarbose; contraindicated for concurrent use)
● Miglitol (similar mechanism conflict as acarbose)

可耐受最高摄入量： No established upper limit; adjust per meal as needed

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Alpha-Galactosidase help with Irritable Bowel Syndrome (IBS)?

Based on 1 studies with 60 participants, there is preliminary evidence that needs more research that Alpha-Galactosidase may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is D (Very Early Research).

How much Alpha-Galactosidase should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Galactosidase?

Reported side effects may include Generally very well-tolerated, Rare allergic reactions to mold-derived enzyme (Aspergillus source), May cause mild GI discomfort in rare cases. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Galactosidase and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 60 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

Alpha-Galactosidase 用于其他健康状况

Bloating and Intestinal Gas B

快速结论

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

Evidence Strength30%

Low confidence

研究分析

RCT (3)Meta (0)Other (0)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Irritable Bowel Syndrome (IBS)

了解更多

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