Vitamin A для Acute Diarrhea
D Исследования Существуют только предварительные исследования (лабораторные исследования, описания случаев).Some evidence in vitamin A-deficient populations. WHO recommends for measles-associated diarrhea. Not effective in non-deficient individuals.
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D
Итог
Some evidence in vitamin A-deficient populations. WHO recommends for measles-associated diarrhea. Not effective in non-deficient individuals.
Key Study Findings
Review
The interplay between malnutrition, persistent diarrhea, lactose intolerance, and food associated gut dysbiosis in children; …
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: children with persistent diarrhea, lactose intolerance, and gut dysbiosis in low/middle-income countries
Other
12 weeks
Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.
Dose: None
или: HFD control mice
Outcome: NAFLD biomarkers and gut microbiota composition
Эффект: None
None
Популяция: HFD-induced NAFLD mouse model
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
или: None
Outcome: Athletic performance and nutritional optimization
Эффект: None
None
Популяция: Vegan athletes (narrative review)
Observational Study
Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …
Dose: None
или: None
Outcome: DALYs and mortality rates of congenital birth defects
Эффект: DALYs decreased 59.77%, deaths decreased 63.81%
None
Популяция: G20 countries population, 1990-2021
Review
B Vitamins, Glucoronolactone and the Immune System: Bioavailability, Doses and Efficiency.
Dose: B vitamins and glucuronolactone
или: None
Outcome: Immune system function
Эффект: None
None
Популяция: General population (review)
Observational Study
n=48
The Resurgence of Measles Infection and its Associated Complications in Early Childhood at a Tertiary …
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: Children with acute diarrhea
Key Statistics
3
Исследования
500
Участники
↑
Positive
D
Оценка
Referenced Papers
BMC pediatrics
2026
BMC pregnancy and …
2025
6 цитирований
Current nutrition reports
2025
3 цитирований
NPJ science of …
2025
2 цитирований
Nutrients
2023
21 цитирований
Polish journal of …
2020
14 цитирований
Brain and nerve …
2019
1 цитирований
PloS one
2018
76 цитирований
Interventions to reduce post-acute consequences of diarrheal disease in children: a systematic review.
Systematic Review
BMC public health
2018
23 цитирований
World journal of …
2016
238 цитирований
Clinics in dermatology
2016
19 цитирований
Systematic reviews
2016
Maternal and child …
2015
23 цитирований
Serum levels of vitamins A and D, and zinc in children with acute diarrhea: A cross-sectional study.
Other
Medical journal of …
2015
15 цитирований
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Other
Journal of pediatric …
2014
38 цитирований
European journal of …
2012
225 цитирований
Journal of burn …
2012
16 цитирований
The Journal of …
2011
30 цитирований
European journal of …
2009
24 цитирований
Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.
Other
American journal of …
2008
25 цитирований
Journal of pediatric …
2006
54 цитирований
Acta paediatrica (Oslo, …
2004
38 цитирований
Biometals : an …
2004
36 цитирований
Journal of health, …
2003
The British journal …
2002
358 цитирований
Pediatrics
2002
154 цитирований
The British journal …
2001
74 цитирований
Journal of pediatric …
2001
56 цитирований
The British journal …
2001
30 цитирований
Journal of tropical …
2001
8 цитирований
The Journal of …
2000
107 цитирований
Journal of pediatric …
2000
20 цитирований
The Pediatric infectious …
2000
14 цитирований
Archivos latinoamericanos de …
1999
3 цитирований
Nutrition (Burbank, Los …
1998
24 цитирований
The Journal of …
1998
3 цитирований
"Feeding the gut": the scientific basis for continued enteral nutrition during acute diarrhea.
Review
The Journal of …
1997
48 цитирований
Breast-feeding status alters the effect of vitamin A treatment during acute diarrhea in children.
RCT
The Journal of …
1997
28 цитирований
The American journal …
1995
103 цитирований
Indian pediatrics
1995
31 цитирований
BMJ (Clinical research …
1994
105 цитирований
The American journal …
1993
42 цитирований
Glimpse (Dhaka, Bangladesh)
1984
The Journal of …
1983
16 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 700-900 mcg RAE/day (RDA for adults)
- gutbarriersupport:
- 900 mcg RAE/day from mixed sources
- deficiencycorrection:
- 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)
Верхний предел: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| None | 12 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| B vitamins and glucuronolactone | -- | Positive | -- |
| None | -- | Mixed | 48 |
| None | -- | Mixed | -- |
| None | 1.0 weeks | Mixed | -- |
Лучшее время приёма: With meals containing fat for better absorption
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Hepatotoxicity at chronic high doses of preformed vitamin A
- ⚠ Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
- ⚠ Nausea, headache, and dizziness
- ⚠ Bone density reduction with long-term excess
Известные взаимодействия
- ● Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
- ● Orlistat (reduces absorption of fat-soluble vitamins)
- ● Alcohol (increases hepatotoxicity risk of vitamin A)
- ● Tetracycline antibiotics (increased risk of intracranial pressure)
Допустимый верхний уровень потребления: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Vitamin A help with Acute Diarrhea?
Based on 3 studies with 500 participants, there is preliminary evidence that needs more research that Vitamin A may support Acute Diarrhea management. Our evidence grade is D (Very Early Research).
How much Vitamin A should I take for Acute Diarrhea?
Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin A?
Reported side effects may include Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin A and Acute Diarrhea?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Acute Diarrhea
Vitamin A для других состояний
References
- [1] Saadia Khan et al.. BMC Pediatr. 2026. The interplay between malnutrition, persistent diarrhea, lactose intolerance, and food associated gut dysbiosis in children; a comprehensive review. doi:10.1186/s12887-026-06529-8 PubMed
- [2] Xiangwen Li et al.. BMC Pregnancy Childbirth. 2025. Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions for 2022-2040. doi:10.1186/s12884-025-07617-w PubMed
- [3] Álvaro Vergara A Nieto et al.. Curr Nutr Rep. 2025. Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review. doi:10.1007/s13668-025-00633-4 PubMed
- [4] Siqi Wang et al.. NPJ Sci Food. 2025. Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics. doi:10.1038/s41538-025-00586-6 PubMed
- [5] Camelia Munteanu et al.. Nutrients. 2023. B Vitamins, Glucoronolactone and the Immune System: Bioavailability, Doses and Efficiency. doi:10.3390/nu16010024 PubMed
- [6] Muhammad Ilyas et al.. Pol J Microbiol. 2020. The Resurgence of Measles Infection and its Associated Complications in Early Childhood at a Tertiary Care Hospital in Peshawar, Pakistan. doi:10.33073/pjm-2020-020 PubMed
- [7] Yuuichi Yamamoto. Brain Nerve. 2019. [Skin Manifestations of Pellagra]. doi:10.11477/mf.1416201276 PubMed
- [8] Ivan D Florez et al.. PLoS One. 2018. Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis. doi:10.1371/journal.pone.0207701 PubMed
- [9] Patricia B Pavlinac et al.. BMC Public Health. 2018. Interventions to reduce post-acute consequences of diarrheal disease in children: a systematic review. doi:10.1186/s12889-018-5092-7 PubMed
- [10] Danuta Owczarek et al.. World J Gastroenterol. 2016. Diet and nutritional factors in inflammatory bowel diseases. doi:10.3748/wjg.v22.i3.895 PubMed
- [11] Meagen McCusker et al.. Clin Dermatol. 2016. Nutrition and skin: Kids are not just little people. doi:10.1016/j.clindermatol.2016.07.004 PubMed
- [12] Ivan D Florez et al.. Syst Rev. 2016. The effectiveness and safety of treatments used for acute diarrhea and acute gastroenteritis in children: protocol for a systematic review … doi:10.1186/s13643-016-0186-8 PubMed
- [13] Rina Agustina et al.. Matern Child Health J. 2015. Maternal agency influences the prevalence of diarrhea and acute respiratory tract infections among young Indonesian children. doi:10.1007/s10995-014-1603-z PubMed
- [14] Elham Talachian et al.. Med J Islam Repub Iran. 2015. Serum levels of vitamins A and D, and zinc in children with acute diarrhea: A cross-sectional study. PubMed
- [15] Neha R Santucci et al.. J Pediatr Gastroenterol Nutr. 2014. Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. doi:10.1097/MPG.0000000000000477 PubMed
- [16] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [17] Nancy Caldis-Coutris et al.. J Burn Care Res. 2012. Zinc supplementation in burn patients. doi:10.1097/BCR.0b013e31824799a3 PubMed
- [18] Phalguni Dutta et al.. J Pediatr. 2011. Zinc, vitamin A, and micronutrient supplementation in children with diarrhea: a randomized controlled clinical trial of combination therapy versus monotherapy. doi:10.1016/j.jpeds.2011.03.028 PubMed
- [19] J L Rosado et al.. Eur J Clin Nutr. 2009. Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: a randomized clinical trial. doi:10.1038/ejcn.2009.53 PubMed
- [20] Bohuslav Melichar et al.. Am J Clin Oncol. 2008. Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea. doi:10.1097/COC.0b013e318174dbb9 PubMed
- [21] Zulfiqar Ahmed Bhutta. J Pediatr Gastroenterol Nutr. 2006. Effect of infections and environmental factors on growth and nutritional status in developing countries. doi:10.1097/01.mpg.0000255846.77034.ed PubMed
- [22] E Villamor et al.. Acta Paediatr. 2004. Human immunodeficiency virus infection, diarrheal disease and sociodemographic predictors of child growth. PubMed
- [23] Delia R Bethell et al.. Biometals. 2004. Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrhea. doi:10.1023/b:biom.0000027714.56331.b8 PubMed
- [24] Ping Chen et al.. J Health Popul Nutr. 2003. Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil. PubMed
- [25] Philip C Calder et al.. Br J Nutr. 2002. The immune system: a target for functional foods? doi:10.1079/BJN2002682 PubMed
- [26] Tor Arne Strand et al.. Pediatrics. 2002. Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children. doi:10.1542/peds.109.5.898 PubMed
- [27] M K Bhan et al.. Br J Nutr. 2001. Micronutrient deficiency in children. doi:10.1079/bjn2001315 PubMed
- [28] S M Filteau et al.. J Pediatr Gastroenterol Nutr. 2001. The effect of antenatal vitamin A and beta-carotene supplementation on gut integrity of infants of HIV-infected South African women. doi:10.1097/00005176-200104000-00014 PubMed
- [29] D Mahalanabis et al.. Br J Nutr. 2001. Micronutrients as adjunct therapy of acute illness in children: impact on the episode outcome and policy implications of current findings. doi:10.1079/bjn2000308 PubMed
- [30] E Granot et al.. J Trop Pediatr. 2001. Oxidative stress is not enhanced in non-malnourished infants with persistent diarrhea. doi:10.1093/tropej/47.5.284 PubMed
- [31] W W Fawzi et al.. J Pediatr. 2000. Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania. doi:10.1067/mpd.2000.110136 PubMed
- [32] K Yurdakök et al.. J Pediatr Gastroenterol Nutr. 2000. Vitamin A supplementation in acute diarrhea. doi:10.1097/00005176-200009000-00006 PubMed
- [33] N C Rollins et al.. Pediatr Infect Dis J. 2000. Vitamin A supplementation of South African children with severe diarrhea: optimum timing for improving biochemical and clinical recovery and subsequent … doi:10.1097/00006454-200004000-00004 PubMed
- [34] D Carías et al.. Arch Latinoam Nutr. 1999. [Nutrient utilization in children with acute diarrhea fed with formulas containing chicken and soybean]. PubMed
- [35] A A Jordão Júnior et al.. Nutrition. 1998. Urinary excretion and plasma vitamin E levels in patients with AIDS. doi:10.1016/s0899-9007(98)00012-4 PubMed
- [36] D I Mehta et al.. J La State Med Soc. 1998. Chronic diarrhea in infancy and childhood. PubMed
- [37] C Duggan et al.. J Pediatr. 1997. "Feeding the gut": the scientific basis for continued enteral nutrition during acute diarrhea. doi:10.1016/s0022-3476(97)70024-6 PubMed
- [38] N Bhandari et al.. J Nutr. 1997. Breast-feeding status alters the effect of vitamin A treatment during acute diarrhea in children. doi:10.1093/jn/127.1.59 PubMed
- [39] J O Alvarez et al.. Am J Clin Nutr. 1995. Urinary excretion of retinol in children with acute diarrhea. doi:10.1093/ajcn/61.6.1273 PubMed
- [40] V Dewan et al.. Indian Pediatr. 1995. A randomized controlled trial of vitamin A supplementation in acute diarrhea. PubMed
- [41] N Bhandari et al.. BMJ. 1994. Impact of massive dose of vitamin A given to preschool children with acute diarrhoea on subsequent respiratory and diarrhoeal morbidity. doi:10.1136/bmj.309.6966.1404 PubMed
- [42] E Salazar-Lindo et al.. Am J Clin Nutr. 1993. Association of diarrhea and low serum retinol in Peruvian children. doi:10.1093/ajcn/58.1.110 PubMed
- [43] . Glimpse. 1984. Bangladesh women scientists' association honours ICDDR,B scientist. PubMed
- [44] A Molla et al.. J Pediatr. 1983. Change in serum vitamin A concentration after an oral dose in children with acute diarrhea. doi:10.1016/s0022-3476(83)80740-9 PubMed
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