Curcumin ： Irritable Bowel Syndrome (IBS)
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。Small RCTs suggest improvement in IBS symptoms. Anti-inflammatory mechanism plausible but evidence insufficient for strong recommendation.
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C
結論
Small RCTs suggest improvement in IBS symptoms. Anti-inflammatory mechanism plausible but evidence insufficient for strong recommendation.
Key Study Findings
Review
Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: patients with IBS (review of plant extracts including peppermint oil, Iberogast, curcumin)
Review
Curcumin in Inflammatory Complications: Therapeutic Applications and Clinical Evidence.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Review of curcumin in inflammatory complications
Systematic Review
n=1123
Double-blind
Potential therapeutic benefits of curcumin in depression or anxiety induced by chronic diseases: a systematic …
Dose: None
vs: Placebo/control
Outcome: Depression and anxiety in chronic diseases
効果: SMD -0.65 [-1.16, -0.13] depression; SMD -0.22 [-0
0.01 (both)
対象集団: Adults with chronic diseases and depression/anxiety (15 RCTs)
Systematic Review
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews …
Dose: None
vs: Various
Outcome: IBS symptom improvement
効果: Probiotics abdominal pain RR 4.04 (2.36-6.92)
None
対象集団: Adult IBS patients
Review
Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Review of herbal remedies for IBS
Systematic Review
A systematic review of the efficacy and safety of turmeric in the treatment of digestive …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: IBS patients
Key Statistics
2
研究数
200
参加者数
↑
Positive
C
グレード
Referenced Papers
Nutrients
2026
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical …
Systematic Review
Nutrition reviews
2025
10 件の引用
Potential therapeutic benefits of curcumin in depression or anxiety induced by chronic diseases: a systematic review of mechanistic and clinical …
Systematic Review
Frontiers in pharmacology
2025
4 件の引用
International journal of …
2025
2 件の引用
Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies.
Review
International journal of …
2025
1 件の引用
A systematic review of the efficacy and safety of turmeric in the treatment of digestive disorders.
Systematic Review
Phytotherapy research : …
2024
10 件の引用
Nutrients
2024
6 件の引用
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 件の引用
CNS & neurological …
2023
24 件の引用
Frontiers in microbiology
2023
11 件の引用
International journal of …
2023
9 件の引用
Nutrients
2022
16 件の引用
Iranian journal of …
2022
12 件の引用
Molecules (Basel, Switzerland)
2021
85 件の引用
BMC complementary medicine …
2021
56 件の引用
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 件の引用
Nutrition research (New …
2020
42 件の引用
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Meta-Analysis
Complementary therapies in …
2020
34 件の引用
Journal of ethnopharmacology
2019
83 件の引用
Current gastroenterology reports
2019
17 件の引用
The American journal …
2019
15 件の引用
Journal of clinical …
2019
3 件の引用
Journal of clinical …
2018
75 件の引用
Annals of gastroenterology
2018
25 件の引用
Medical principles and …
2017
45 件の引用
Phytotherapy research : …
2017
26 件の引用
Current gastroenterology reports
2017
16 件の引用
The Medical clinics …
2017
9 件の引用
Journal of gastrointestinal …
2016
96 件の引用
Current gastroenterology reports
2016
30 件の引用
Metabolic brain disease
2015
62 件の引用
Voprosy pitaniia
2015
8 件の引用
The AAPS journal
2013
1866 件の引用
Molecular nutrition & …
2013
395 件の引用
Voprosy pitaniia
2013
Clinics (Sao Paulo, …
2010
47 件の引用
Indian journal of …
2010
14 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
上限量： Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | 1123 |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| Peppermint oil, STW-5, psyllium, others | -- | Positive | -- |
| 200 mg | 8 weeks | Positive | -- |
推奨摂取タイミング： With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
報告されている副作用
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
既知の相互作用
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
耐容上限摂取量： Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Curcumin help with Irritable Bowel Syndrome (IBS)?
Based on 2 studies with 200 participants, there is limited but promising evidence that Curcumin may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).
How much Curcumin should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Irritable Bowel Syndrome (IBS)
Curcumin 他の症状・状態について
References
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- [2] Sheida Zeraattalab-Motlagh et al.. Nutr Rev. 2025. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical … doi:10.1093/nutrit/nuae107 PubMed
- [3] Jiyuan Yuan et al.. Front Pharmacol. 2025. Potential therapeutic benefits of curcumin in depression or anxiety induced by chronic diseases: a systematic review of mechanistic and clinical … doi:10.3389/fphar.2025.1638645 PubMed
- [4] Amber Zafar et al.. Int J Mol Sci. 2025. Curcumin in Inflammatory Complications: Therapeutic Applications and Clinical Evidence. doi:10.3390/ijms26199366 PubMed
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