Lactobacillus plantarum ： Irritable Bowel Syndrome (IBS)
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。Reduces abdominal pain and bloating in IBS. Multiple RCTs show significant improvement in global IBS symptom scores. Strain-specific evidence for 299v is relatively strong.
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B
結論
Reduces abdominal pain and bloating in IBS. Multiple RCTs show significant improvement in global IBS symptom scores. Strain-specific evidence for 299v is relatively strong.
Key Study Findings
Meta-Analysis
n=3154
Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …
Dose: None
vs: placebo
Outcome: quality of life, depression, and anxiety in IBS …
効果: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression)
None
対象集団: patients with irritable bowel syndrome
Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None
vs: placebo
Outcome: improvement in key IBS symptoms
効果: None
None
対象集団: patients with IBS from 32 RCTs evaluating 10 probiotic strains
Other
n=25
4 weeks
Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 …
Dose: Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917
vs: phosphate-buffered saline (PBS)
Outcome: visceral hypersensitivity (abdominal withdrawal reflex scores)
効果: None
p<0.05
対象集団: female rats with water avoidance stress-induced IBS-D model
Other
Lactobacillus plantarum and Galacto-Oligosaccharides Synbiotic Relieve Irritable Bowel Syndrome by Reshaping Gut Microbiota and Attenuating …
Dose: 1e9 CFU/day + GOS 10 g/L
vs: IBS model mice without synbiotic
Outcome: IBS symptoms and colonic dysfunction
効果: None
<0.05
対象集団: C. rodentium + WAS IBS mouse model
Other
Synergistic Modulation of the Gut-Brain-Immune Axis by a Dual Lactobacillus Combination in a Murine IBS …
Dose: None
vs: Single-strain or vehicle control
Outcome: IBS-like symptoms in zymosan-induced mouse model
効果: None
None
対象集団: Zymosan-induced IBS mouse model
Randomized Controlled Trial
n=61
12 weeks
Double-blind
Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel …
Dose: None
vs: Placebo
Outcome: IBS-SSS (100-point reduction)
効果: 45% active vs 33% placebo (P=0.42)
P=0.42
対象集団: IBD patients with IBS symptoms in remission
Key Statistics
5
研究数
800
参加者数
↑
Positive
B
グレード
Referenced Papers
Journal of clinical …
2026
European journal of …
2026
Journal of the …
2026
Nutrients
2025
6 件の引用
World journal of …
2025
2 件の引用
Journal of microbiology …
2025
1 件の引用
Beneficial microbes
2025
Food & function
2024
14 件の引用
Minerva gastroenterology
2024
4 件の引用
Journal of neurogastroenterology …
2024
4 件の引用
Frontiers in medicine
2024
2 件の引用
Journal of applied …
2024
1 件の引用
Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis.
Meta-Analysis
Gastroenterology
2023
75 件の引用
Drugs
2023
21 件の引用
Food & nutrition …
2022
26 件の引用
Journal of neurogastroenterology …
2022
21 件の引用
Nutrients
2022
20 件の引用
Frontiers in nutrition
2022
13 件の引用
JPMA. The Journal …
2022
6 件の引用
Beneficial microbes
2021
69 件の引用
Frontiers in immunology
2021
67 件の引用
European journal of …
2021
49 件の引用
Microorganisms
2021
47 件の引用
Digestive diseases (Basel, …
2021
28 件の引用
Food & function
2021
21 件の引用
Frontiers in pain …
2021
15 件の引用
Przeglad gastroenterologiczny
2021
14 件の引用
Central-European journal of …
2020
38 件の引用
The primary care …
2020
32 件の引用
Nutrition journal
2020
28 件の引用
European review for …
2020
21 件の引用
Probiotics and antimicrobial …
2020
21 件の引用
Probiotics and antimicrobial …
2019
43 件の引用
Foods (Basel, Switzerland)
2019
21 件の引用
Acta bio-medica : …
2019
6 件の引用
Food & function
2018
77 件の引用
Digestive diseases and …
2018
57 件の引用
Applied microbiology and …
2015
107 件の引用
Nutrition (Burbank, Los …
2014
64 件の引用
Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis.
Meta-Analysis
Revista espanola de …
2013
102 件の引用
PloS one
2012
445 件の引用
World journal of …
2012
277 件の引用
Journal of clinical …
2012
207 件の引用
Polski merkuriusz lekarski …
2012
8 件の引用
Revista espanola de …
2009
1 件の引用
Use of diet and probiotic therapy in the irritable bowel syndrome: analysis of the literature.
Review
Journal of clinical …
2005
54 件の引用
Zeitschrift fur Gastroenterologie
2005
17 件の引用
Journal of clinical …
2004
205 件の引用
Anaerobe
2004
40 件の引用
Digestive diseases and …
2002
250 件の引用
Current treatment options …
2002
5 件の引用
European journal of …
2001
518 件の引用
The American journal …
2000
648 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 10-20 billion CFU/day
- ibssupport:
- 10 billion CFU/day (299v strain) for 4 weeks minimum
上限量： Well-tolerated up to 20 billion CFU/day in clinical trials
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | 3154 |
| None | -- | Positive | -- |
| Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 | 4 weeks | Positive | 25 |
| 1e9 CFU/day + GOS 10 g/L | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 12 weeks | Neutral | 61 |
| None | 8 weeks | Positive | 1098 |
| 10 μg | 6 weeks | Positive | 246 |
推奨摂取タイミング： On an empty stomach or before meals
Safety & Side Effects
報告されている副作用
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional loose stools
- ⚠ Histamine-related symptoms in sensitive individuals (histamine-producing species)
- ⚠ Very rare: bacteremia in immunocompromised individuals
既知の相互作用
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (theoretical risk in immunocompromised patients)
- ● Histamine-intolerance medications (L. plantarum may produce biogenic amines)
耐容上限摂取量： Well-tolerated up to 20 billion CFU/day in clinical trials
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Lactobacillus plantarum help with Irritable Bowel Syndrome (IBS)?
Based on 5 studies with 800 participants, there is moderate evidence from clinical studies that Lactobacillus plantarum may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).
How much Lactobacillus plantarum should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus plantarum?
Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Histamine-related symptoms in sensitive individuals (histamine-producing species), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus plantarum and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Irritable Bowel Syndrome (IBS)
References
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