Curcumin ： Crohn's Disease
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。Limited RCT evidence. Some improvement in CDAI scores but results inconsistent. Better evidence exists for UC than Crohn's.
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C
結論
Limited RCT evidence. Some improvement in CDAI scores but results inconsistent. Better evidence exists for UC than Crohn's.
Key Study Findings
Meta-Analysis
n=2260
Comparative Efficacy of Medical Therapies in Reducing the Risk of Postoperative Recurrence in Crohn's Disease: …
Dose: None
vs: placebo or other medical therapies
Outcome: endoscopic recurrence (Rutgeerts score >= i2) at 6 …
効果: adalimumab vs thiopurines OR 0.33 (95% CI 0.12-0.91); adalimumab vs vitamin D OR 0.07 (95% CI 0.01-0
None
対象集団: patients with Crohn's disease post-surgery from 42 studies (38 RCTs)
Meta-Analysis
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of …
Dose: Varying dosages
vs: Placebo
Outcome: Clinical remission and response in UC
効果: None
None
対象集団: UC and CD patients (13 RCTs)
Systematic Review
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Dose: Peppermint oil, STW-5, psyllium, others
vs: Standard care or placebo
Outcome: Symptom improvement in GI diseases
効果: None
None
対象集団: Patients with gastroenterological diseases
Review
Use of curcumin and its nanopreparations in the treatment of inflammatory bowel disease.
Dose: Curcumin nanoformulations
vs: None
Outcome: IBD symptom improvement
効果: None
None
対象集団: IBD patients (preclinical/clinical review)
Review
Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and …
Dose: Various phytochemicals
vs: None
Outcome: NF-kB regulation in IBD
効果: None
None
対象集団: In vitro and in vivo IBD models
Meta-Analysis
Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A …
Dose: None
vs: Placebo or standard care
Outcome: Clinical/laboratory outcomes in autoimmune diseases
効果: None
None
対象集団: Patients with 10 types of autoimmune diseases
Key Statistics
3
研究数
200
参加者数
↔
Mixed
C
グレード
Referenced Papers
Inflammatory bowel diseases
2026
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 件の引用
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 件の引用
World journal of …
2024
Metabolites
2023
134 件の引用
Frontiers in immunology
2022
68 件の引用
Molecules (Basel, Switzerland)
2021
85 件の引用
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 件の引用
United European gastroenterology …
2021
41 件の引用
European journal of …
2021
40 件の引用
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 件の引用
Journal of Crohn's …
2020
71 件の引用
Clinical gastroenterology and …
2020
49 件の引用
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 件の引用
Nutrients
2020
30 件の引用
Digestive and liver …
2020
14 件の引用
Medicine
2020
4 件の引用
International journal of …
2019
137 件の引用
Critical reviews in …
2019
48 件の引用
Journal of medicinal …
2019
17 件の引用
Current opinion in …
2019
5 件の引用
Gastroenterology clinics of …
2018
67 件の引用
Macromolecular bioscience
2018
13 件の引用
Gastroenterology
2017
335 件の引用
Medical principles and …
2017
45 件の引用
JPEN. Journal of …
2017
24 件の引用
Comparison of remicade to curcumin for the treatment of Crohn's disease: A systematic review.
Systematic Review
Complementary therapies in …
2017
23 件の引用
The Medical clinics …
2017
9 件の引用
Ugeskrift for laeger
2017
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 件の引用
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 件の引用
Annals of gastroenterology
2015
135 件の引用
Molecules (Basel, Switzerland)
2014
122 件の引用
Experimental cell research
2014
16 件の引用
The AAPS journal
2013
1866 件の引用
Alimentary pharmacology & …
2013
128 件の引用
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 件の引用
Nature reviews. Gastroenterology …
2013
47 件の引用
Food & function
2012
151 件の引用
Journal of the …
2009
24 件の引用
Molecular nutrition & …
2008
67 件の引用
Revista de gastroenterologia …
2008
2 件の引用
Digestive diseases and …
2005
461 件の引用
Bioinformatics (Oxford, England)
2004
149 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
上限量： Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | 2260 |
| Varying dosages | -- | Positive | -- |
| Peppermint oil, STW-5, psyllium, others | -- | Positive | -- |
| Curcumin nanoformulations | -- | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
報告されている副作用
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
既知の相互作用
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
耐容上限摂取量： Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Curcumin help with Crohn's Disease?
Based on 3 studies with 200 participants, there is limited but promising evidence that Curcumin may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much Curcumin should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is mixed.
Related Evidence
に関する他の成分： Crohn's Disease
Curcumin 他の症状・状態について
References
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