Peppermint Oil ： Irritable Bowel Syndrome (IBS)
A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。Meta-analyses of 12+ RCTs demonstrate peppermint oil (450-750 mg/day enteric-coated) significantly reduces IBS abdominal pain (RR 1.78 vs placebo). A-grade evidence for global IBS symptom improvement. ACG conditional recommendation.
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A
結論
Meta-analyses of 12+ RCTs demonstrate peppermint oil (450-750 mg/day enteric-coated) significantly reduces IBS abdominal pain (RR 1.78 vs placebo). A-grade evidence for global IBS symptom improvement. ACG conditional recommendation.
Key Study Findings
Review
Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: patients with IBS (review of plant extracts including peppermint oil, Iberogast, curcumin)
Review
European Consensus on Functional Bloating and Abdominal Distension-An ESNM/UEG Recommendations for Clinical Management.
Dose: None
vs: None
Outcome: Functional bloating and abdominal distension management
効果: None
None
対象集団: Patients with functional bloating/distension (consensus)
Review
Mechanisms of action and clinical effectiveness of herbal treatments for disorders of gut-brain interaction.
Dose: None
vs: Placebo
Outcome: GI symptoms in DGBI (FD, IBS)
効果: None
None
対象集団: Patients with functional dyspepsia and IBS (review)
Review
Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Review of herbal remedies for IBS
Review
Diet, nutraceuticals, and lifestyle interventions for the treatment and management of irritable bowel syndrome.
Dose: None
vs: None
Outcome: IBS symptom management
効果: None
None
対象集団: Patients with IBS (review)
Review
Natural Products for the Treatment of Irritable Bowel Syndrome.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Patients with irritable bowel syndrome
Key Statistics
19
研究数
2569
参加者数
↑
Positive
A
グレード
Referenced Papers
Nutrients
2026
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical …
Systematic Review
Nutrition reviews
2025
10 件の引用
Journal of clinical …
2025
8 件の引用
United European gastroenterology …
2025
5 件の引用
Digestive and liver …
2025
4 件の引用
Nutrition in clinical …
2025
3 件の引用
Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies.
Review
International journal of …
2025
1 件の引用
Gastroenterology & hepatology
2025
The Medical letter …
2025
Nutrients
2024
5 件の引用
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 件の引用
BioPsychoSocial medicine
2024
3 件の引用
Current pharmaceutical design
2023
12 件の引用
Nutrients
2023
4 件の引用
Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome.
Meta-Analysis
Alimentary pharmacology & …
2022
35 件の引用
American journal of …
2022
18 件の引用
Nutrition & dietetics …
2022
12 件の引用
Neurogastroenterology and motility
2022
11 件の引用
Alimentary pharmacology & …
2022
1 件の引用
Alimentary pharmacology & …
2022
Frontline gastroenterology
2021
56 件の引用
The American journal …
2021
31 件の引用
The lancet. Gastroenterology …
2020
119 件の引用
Gastroenterology
2020
96 件の引用
Nutrition research (New …
2020
42 件の引用
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Meta-Analysis
Complementary therapies in …
2020
34 件の引用
Neurogastroenterology and motility
2020
34 件の引用
Gastroenterology
2020
8 件の引用
Journal of the …
2020
1 件の引用
The Medical letter …
2020
Journal of the …
2019
171 件の引用
The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data.
Meta-Analysis
BMC complementary and …
2019
167 件の引用
Current gastroenterology reports
2019
18 件の引用
World journal of …
2019
14 件の引用
Alimentary pharmacology & …
2018
148 件の引用
Nutrients
2018
54 件の引用
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders.
Review
British journal of …
2017
145 件の引用
Journal of gastroenterology …
2017
32 件の引用
Current opinion in …
2017
24 件の引用
Current gastroenterology reports
2017
16 件の引用
Handbook of experimental …
2017
4 件の引用
American journal of …
2016
15 件の引用
Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis.
Meta-Analysis
Journal of clinical …
2014
186 件の引用
World journal of …
2014
109 件の引用
Digestion
2014
61 件の引用
Journal of gastroenterology
2014
47 件の引用
Voprosy pitaniia
2013
FP essentials
2013
Irritable bowel syndrome.
Systematic Review
BMJ clinical evidence
2012
6 件の引用
Journal of clinical …
2011
30 件の引用
Discovery medicine
2011
Therapy options in irritable bowel syndrome.
Meta-Analysis
European journal of …
2010
61 件の引用
Irritable bowel syndrome.
Systematic Review
BMJ clinical evidence
2010
Canadian family physician …
2009
108 件の引用
Journal of the …
2009
40 件の引用
Australian family physician
2009
12 件の引用
BMJ (Clinical research …
2008
550 件の引用
Peppermint oil.
Review
American family physician
2007
125 件の引用
A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.).
Review
Phytotherapy research : …
2006
698 件の引用
Current treatment options …
2006
24 件の引用
Peppermint oil.
Review
Pediatrics in review
2006
2 件の引用
Phytomedicine : international …
2005
72 件の引用
American family physician
2005
The American journal …
1998
266 件の引用
The American journal …
1998
13 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 450-750 mg/day enteric-coated capsules
- ibssymptomsupport:
- 187-225 mg enteric-coated capsules, 2-3 times daily, 30-60 min before meals
上限量： Well-tolerated up to 1,200 mg/day in clinical trials; enteric coating essential
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： 30-60 minutes before meals; enteric-coated capsules MUST be swallowed whole (do not chew or crush)
Safety & Side Effects
報告されている副作用
- ⚠ Heartburn/GERD exacerbation (if non-enteric-coated; relaxes lower esophageal sphincter)
- ⚠ Perianal burning sensation (from undigested menthol reaching the rectum)
- ⚠ Nausea at high doses
- ⚠ Allergic reactions in mint-sensitive individuals
既知の相互作用
- ● Cyclosporine (peppermint may increase cyclosporine levels via CYP3A4 inhibition)
- ● Antacids and PPIs (may dissolve enteric coating prematurely; space 2 hours)
- ● Simethicone (coated formulations may interact with enteric-coated peppermint)
- ● CYP2C19 substrates (menthol is a weak CYP inhibitor)
耐容上限摂取量： Well-tolerated up to 1,200 mg/day in clinical trials; enteric coating essential
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Peppermint Oil help with Irritable Bowel Syndrome (IBS)?
Based on 19 studies with 2,569 participants, there is strong evidence from multiple clinical trials that Peppermint Oil may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is A (Strong Evidence).
How much Peppermint Oil should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 450-750 mg/day enteric-coated capsules. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Peppermint Oil?
Reported side effects may include Heartburn/GERD exacerbation (if non-enteric-coated; relaxes lower esophageal sphincter), Perianal burning sensation (from undigested menthol reaching the rectum), Nausea at high doses, Allergic reactions in mint-sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Peppermint Oil and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 19 peer-reviewed studies with 2,569 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Irritable Bowel Syndrome (IBS)
References
- [1] Ploutarchos Pastras et al.. Nutrients. 2026. Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines. doi:10.3390/nu18020183 PubMed
- [2] Sheida Zeraattalab-Motlagh et al.. Nutr Rev. 2025. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical … doi:10.1093/nutrit/nuae107 PubMed
- [3] Giovanni Marasco et al.. J Clin Med. 2025. Functional Foods and Nutraceuticals in Irritable Bowel Syndrome. doi:10.3390/jcm14061830 PubMed
- [4] Chloé Melchior et al.. United European Gastroenterol J. 2025. European Consensus on Functional Bloating and Abdominal Distension-An ESNM/UEG Recommendations for Clinical Management. doi:10.1002/ueg2.70098 PubMed
- [5] Md Moniruzzaman et al.. Dig Liver Dis. 2025. Mechanisms of action and clinical effectiveness of herbal treatments for disorders of gut-brain interaction. doi:10.1016/j.dld.2025.07.010 PubMed
- [6] Zoe N Memel et al.. Nutr Clin Pract. 2025. Diet, nutraceuticals, and lifestyle interventions for the treatment and management of irritable bowel syndrome. doi:10.1002/ncp.11307 PubMed
- [7] Raquel Abalo et al.. Int J Mol Sci. 2025. Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies. doi:10.3390/ijms26199345 PubMed
- [8] Sophie Brigstocke et al.. Gastroenterol Hepatol (N Y). 2025. Natural Products for the Treatment of Irritable Bowel Syndrome. PubMed
- [9] . Med Lett Drugs Ther. 2025. Drugs for irritable bowel syndrome. doi:10.58347/tml.2025.1721a PubMed
- [10] Silvia Salvatore et al.. Nutrients. 2024. Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights. doi:10.3390/nu16030349 PubMed
- [11] Sandra Utz et al.. Z Gastroenterol. 2024. [Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review]. doi:10.1055/a-2279-5045 PubMed
- [12] Kei Matsueda et al.. Biopsychosoc Med. 2024. Efficacy and safety of peppermint oil for the treatment in Japanese patients with irritable bowel syndrome: a prospective, open-label, and … doi:10.1186/s13030-024-00302-y PubMed
- [13] Emidio Scarpellini et al.. Curr Pharm Des. 2023. The Use of Peppermint Oil in Gastroenterology. doi:10.2174/1381612829666230328163449 PubMed
- [14] Daniela Pop et al.. Nutrients. 2023. The Use of Fibers, Herbal Medicines and Spices in Children with Irritable Bowel Syndrome: A Narrative Review. doi:10.3390/nu15204351 PubMed
- [15] Maria Rosa Ingrosso et al.. Aliment Pharmacol Ther. 2022. Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome. doi:10.1111/apt.17179 PubMed
- [16] Andrew Thomas et al.. Am J Lifestyle Med. 2022. Dietary Modification for the Restoration of Gut Microbiome and Management of Symptoms in Irritable Bowel Syndrome. doi:10.1177/15598276211012968 PubMed
- [17] Joanna Giang et al.. Nutr Diet. 2022. Efficacy and safety of biophenol-rich nutraceuticals in adults with inflammatory gastrointestinal diseases or irritable bowel syndrome: A systematic literature review … doi:10.1111/1747-0080.12672 PubMed
- [18] Joelle BouSaba et al.. Neurogastroenterol Motil. 2022. Pain in irritable bowel syndrome: Does anything really help? doi:10.1111/nmo.14305 PubMed
- [19] Yu Gu et al.. Aliment Pharmacol Ther. 2022. Letter: efficacy of peppermint oil in irritable bowel syndrome. doi:10.1111/apt.17194 PubMed
- [20] Maria Rosa Ingrosso et al.. Aliment Pharmacol Ther. 2022. Letter: efficacy of peppermint oil in irritable bowel syndrome-authors' reply. doi:10.1111/apt.17197 PubMed
- [21] Christopher J Black et al.. Frontline Gastroenterol. 2021. Best management of irritable bowel syndrome. doi:10.1136/flgastro-2019-101298 PubMed
- [22] Judy Nee et al.. Am J Gastroenterol. 2021. Peppermint Oil Treatment for Irritable Bowel Syndrome: A Randomized Placebo-Controlled Trial. doi:10.14309/ajg.0000000000001395 PubMed
- [23] Christopher J Black et al.. Lancet Gastroenterol Hepatol. 2020. Efficacy of soluble fibre, antispasmodic drugs, and gut-brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis. doi:10.1016/S2468-1253(19)30324-3 PubMed
- [24] Zsa Zsa R M Weerts et al.. Gastroenterology. 2020. Efficacy and Safety of Peppermint Oil in a Randomized, Double-Blind Trial of Patients With Irritable Bowel Syndrome. doi:10.1053/j.gastro.2019.08.026 PubMed
- [25] Karin Ried et al.. Nutr Res. 2020. Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. doi:10.1016/j.nutres.2020.02.008 PubMed
- [26] Jason A Hawrelak et al.. Complement Ther Med. 2020. Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis. doi:10.1016/j.ctim.2019.102233 PubMed
- [27] Eirini Dimidi et al.. Neurogastroenterol Motil. 2020. Food supplements and diet as treatment options in irritable bowel syndrome. doi:10.1111/nmo.13951 PubMed
- [28] Christopher J Black et al.. Gastroenterology. 2020. Peppermint Oil in Irritable Bowel Syndrome. doi:10.1053/j.gastro.2019.09.055 PubMed
- [29] Christopher N Andrews et al.. J Can Assoc Gastroenterol. 2020. Diarrhea-Predominant Irritable Bowel Syndrome: Medical Management Update. doi:10.1093/jcag/gwz034 PubMed
- [30] . Med Lett Drugs Ther. 2020. Drugs for Irritable Bowel Syndrome. PubMed
- [31] Paul Moayyedi et al.. J Can Assoc Gastroenterol. 2019. Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Irritable Bowel Syndrome (IBS). doi:10.1093/jcag/gwy071 PubMed
- [32] N Alammar et al.. BMC Complement Altern Med. 2019. The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data. doi:10.1186/s12906-018-2409-0 PubMed
- [33] Akhil Munjal et al.. Curr Gastroenterol Rep. 2019. Update on Pharmacotherapy for Irritable Bowel Syndrome. doi:10.1007/s11894-019-0692-7 PubMed
- [34] Liang Dai et al.. World J Clin Cases. 2019. Irritable bowel syndrome and functional constipation management with integrative medicine: A systematic review. doi:10.12998/wjcc.v7.i21.3486 PubMed
- [35] B P Chumpitazi et al.. Aliment Pharmacol Ther. 2018. Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional … doi:10.1111/apt.14519 PubMed
- [36] Amanda C Fifi et al.. Nutrients. 2018. Herbs and Spices in the Treatment of Functional Gastrointestinal Disorders: A Review of Clinical Trials. doi:10.3390/nu10111715 PubMed
- [37] Diego Currò et al.. Br J Pharmacol. 2017. Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders. doi:10.1111/bph.13632 PubMed
- [38] Emma P Halmos. J Gastroenterol Hepatol. 2017. When the low FODMAP diet does not work. doi:10.1111/jgh.13701 PubMed
- [39] Eirini Dimidi et al.. Curr Opin Clin Nutr Metab Care. 2017. Irritable bowel syndrome and diet: where are we in 2018? doi:10.1097/MCO.0000000000000416 PubMed
- [40] Brent W Acker et al.. Curr Gastroenterol Rep. 2017. Medicinal Foods for Functional GI Disorders. doi:10.1007/s11894-017-0601-x PubMed
- [41] Miguel Saps et al.. Handb Exp Pharmacol. 2017. Gastrointestinal Pharmacology. doi:10.1007/164_2016_119 PubMed
- [42] Stacy L Haber et al.. Am J Health Syst Pharm. 2016. Peppermint oil for treatment of irritable bowel syndrome. doi:10.2146/ajhp140801 PubMed
- [43] Reena Khanna et al.. J Clin Gastroenterol. 2014. Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis. doi:10.1097/MCG.0b013e3182a88357 PubMed
- [44] Oliver Grundmann et al.. World J Gastroenterol. 2014. Complementary and alternative medicines in irritable bowel syndrome: an integrative view. doi:10.3748/wjg.v20.i2.346 PubMed
- [45] Katy E Trinkley et al.. Digestion. 2014. Medication management of irritable bowel syndrome. doi:10.1159/000362405 PubMed
- [46] Tim Vanuytsel et al.. J Gastroenterol. 2014. Treatment of abdominal pain in irritable bowel syndrome. doi:10.1007/s00535-014-0966-7 PubMed
- [47] V I Pilipenko et al.. Vopr Pitan. 2013. [Contemporary dietotherapy of the irritable bowel syndrome]. PubMed
- [48] Julia Fashner et al.. FP Essent. 2013. Common gastrointestinal symptoms: irritable bowel syndrome. PubMed
- [49] Alexander Charles Ford et al.. BMJ Clin Evid. 2012. Irritable bowel syndrome. PubMed
- [50] K E Trinkley et al.. J Clin Pharm Ther. 2011. Treatment of irritable bowel syndrome. doi:10.1111/j.1365-2710.2010.01177.x PubMed
- [51] Nicole C Suares et al.. Discov Med. 2011. Diagnosis and treatment of irritable bowel syndrome. PubMed
- [52] Paul Enck et al.. Eur J Gastroenterol Hepatol. 2010. Therapy options in irritable bowel syndrome. doi:10.1097/MEG.0b013e3283405a17 PubMed
- [53] Alexander Charles Ford et al.. BMJ Clin Evid. 2010. Irritable bowel syndrome. PubMed
- [54] Yi-Hao A Shen et al.. Can Fam Physician. 2009. Complementary and alternative medicine for treatment of irritable bowel syndrome. PubMed
- [55] Full-Young Chang et al.. J Chin Med Assoc. 2009. Treatment of irritable bowel syndrome using complementary and alternative medicine. doi:10.1016/S1726-4901(09)70375-2 PubMed
- [56] Marie Pirotta. Aust Fam Physician. 2009. Irritable bowel syndrome - The role of complementary medicines in treatment. PubMed
- [57] Alexander C Ford et al.. BMJ. 2008. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. doi:10.1136/bmj.a2313 PubMed
- [58] Benjamin Kligler et al.. Am Fam Physician. 2007. Peppermint oil. PubMed
- [59] Diane L McKay et al.. Phytother Res. 2006. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). doi:10.1002/ptr.1936 PubMed
- [60] Howard Y Chang et al.. Curr Treat Options Gastroenterol. 2006. Current gut-directed therapies for irritable bowel syndrome. doi:10.1007/s11938-006-0013-8 PubMed
- [61] Theresa L Charrois et al.. Pediatr Rev. 2006. Peppermint oil. doi:10.1542/pir.27-7-e49 PubMed
- [62] H G Grigoleit et al.. Phytomedicine. 2005. Peppermint oil in irritable bowel syndrome. doi:10.1016/j.phymed.2004.10.005 PubMed
- [63] Susan K Hadley et al.. Am Fam Physician. 2005. Treatment of irritable bowel syndrome. PubMed
- [64] M H Pittler et al.. Am J Gastroenterol. 1998. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. doi:10.1111/j.1572-0241.1998.00343.x PubMed
- [65] T R Koch. Am J Gastroenterol. 1998. Peppermint oil and irritable bowel syndrome. doi:10.1111/j.1572-0241.1998.02304.x PubMed
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。