Curcumin ： Ulcerative Colitis (UC)
BMulticenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
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B
結論
Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
Key Study Findings
Systematic Review
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Dose: None
vs: placebo or standard therapy
Outcome: ulcerative colitis outcomes (18 outcomes across 7 SR/MAs)
効果: None
None
対象集団: patients with ulcerative colitis
Other
Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis.
Dose: None
vs: untreated colitis controls
Outcome: mitigation of colitis symptoms (ROS scavenging, barrier restoration, …
効果: None
None
対象集団: UC animal model and oxidatively stressed colon cells
Review
Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Systematic Review
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Dose: None
vs: Various comparators
Outcome: Multiple health outcomes
効果: None
None
対象集団: Human subjects across 25 meta-analyses
Review
Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
In Vitro
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
Dose: None
vs: DSS-induced UC mice
Outcome: UC inflammation via SphK1/NF-kB pathway
効果: None
None
対象集団: DSS-induced UC murine model
Key Statistics
5
研究数
400
参加者数
↑
Positive
B
グレード
Referenced Papers
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Systematic Review
Nutrition reviews
2026
ACS nano
2025
29 件の引用
Frontiers in immunology
2025
20 件の引用
Naunyn-Schmiedeberg's archives of …
2025
14 件の引用
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Systematic Review
Frontiers in pharmacology
2025
10 件の引用
BioFactors (Oxford, England)
2025
9 件の引用
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 件の引用
European journal of …
2025
7 件の引用
Explore (New York, …
2025
5 件の引用
Journal of agricultural …
2025
3 件の引用
Materials today. Bio
2025
3 件の引用
Frontiers in nutrition
2025
2 件の引用
Frontiers in pharmacology
2025
1 件の引用
Cellular and molecular …
2025
Nutrients
2025
International journal of …
2025
Clinical gastroenterology and …
2024
52 件の引用
Food research international …
2024
44 件の引用
Advanced materials (Deerfield …
2024
37 件の引用
Journal of pharmaceutical …
2024
29 件の引用
International journal of …
2024
27 件の引用
Nutrients
2024
23 件の引用
ACS omega
2024
16 件の引用
Frontiers in pediatrics
2024
4 件の引用
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 件の引用
World journal of …
2024
Frontiers in endocrinology
2023
253 件の引用
Metabolites
2023
134 件の引用
Advanced science (Weinheim, …
2023
90 件の引用
Journal of nanobiotechnology
2023
63 件の引用
Pharmaceuticals (Basel, Switzerland)
2023
18 件の引用
Toxicology mechanisms and …
2023
5 件の引用
Journal of nanobiotechnology
2022
206 件の引用
International journal of …
2022
142 件の引用
The American journal …
2022
86 件の引用
Frontiers in immunology
2022
68 件の引用
Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis.
Meta-Analysis
Journal of ethnopharmacology
2022
39 件の引用
American family physician
2022
38 件の引用
Nutrients
2022
19 件の引用
Turkish journal of …
2022
3 件の引用
Advances in experimental …
2021
87 件の引用
Molecules (Basel, Switzerland)
2021
85 件の引用
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 件の引用
European journal of …
2021
40 件の引用
Complementary therapies in …
2021
30 件の引用
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 件の引用
Clinical gastroenterology and …
2020
49 件の引用
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 件の引用
Nutrients
2020
30 件の引用
Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials.
Meta-Analysis
Journal of gastroenterology …
2020
30 件の引用
Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis.
Meta-Analysis
Expert review of …
2020
25 件の引用
Therapeutic advances in …
2020
21 件の引用
Medicine
2020
4 件の引用
International journal of …
2019
137 件の引用
Nutrients
2019
71 件の引用
Critical reviews in …
2019
48 件の引用
Journal of medicinal …
2019
17 件の引用
Immunopharmacology and immunotoxicology
2018
96 件の引用
Gastroenterology clinics of …
2018
67 件の引用
Nutrients
2018
46 件の引用
Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis.
Meta-Analysis
The American journal …
2018
30 件の引用
Medical principles and …
2017
45 件の引用
Acta medica Indonesiana
2017
24 件の引用
The Medical clinics …
2017
9 件の引用
Ugeskrift for laeger
2017
Annals of gastroenterology
2016
41 件の引用
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 件の引用
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 件の引用
Annals of gastroenterology
2015
135 件の引用
Molecules (Basel, Switzerland)
2014
122 件の引用
World journal of …
2014
23 件の引用
The AAPS journal
2013
1866 件の引用
Alimentary pharmacology & …
2013
128 件の引用
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 件の引用
Food & function
2012
151 件の引用
Revista de gastroenterologia …
2008
2 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
上限量： Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| Varying dosages | -- | Positive | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
報告されている副作用
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
既知の相互作用
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
耐容上限摂取量： Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Curcumin help with Ulcerative Colitis (UC)?
Based on 5 studies with 400 participants, there is moderate evidence from clinical studies that Curcumin may support Ulcerative Colitis (UC) management. Our evidence grade is B (Good Evidence).
How much Curcumin should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Ulcerative Colitis (UC)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Ulcerative Colitis (UC)
Curcumin 他の症状・状態について
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