Curcumin ： Ulcerative Colitis (UC)
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
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B
結論
Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
Key Study Findings
Systematic Review
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Dose: None
vs: placebo or standard therapy
Outcome: ulcerative colitis outcomes (18 outcomes across 7 SR/MAs)
効果: None
None
対象集団: patients with ulcerative colitis
Other
Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis.
Dose: None
vs: untreated colitis controls
Outcome: mitigation of colitis symptoms (ROS scavenging, barrier restoration, …
効果: None
None
対象集団: UC animal model and oxidatively stressed colon cells
Review
Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Systematic Review
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Dose: None
vs: Various comparators
Outcome: Multiple health outcomes
効果: None
None
対象集団: Human subjects across 25 meta-analyses
Review
Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
In Vitro
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
Dose: None
vs: DSS-induced UC mice
Outcome: UC inflammation via SphK1/NF-kB pathway
効果: None
None
対象集団: DSS-induced UC murine model
Key Statistics
5
研究数
400
参加者数
↑
Positive
B
グレード
Referenced Papers
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Systematic Review
Nutrition reviews
2026
ACS nano
2025
29 件の引用
Frontiers in immunology
2025
20 件の引用
Naunyn-Schmiedeberg's archives of …
2025
14 件の引用
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Systematic Review
Frontiers in pharmacology
2025
10 件の引用
BioFactors (Oxford, England)
2025
9 件の引用
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 件の引用
European journal of …
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7 件の引用
Explore (New York, …
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Journal of agricultural …
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Materials today. Bio
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Nutrients
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Metabolites
2023
134 件の引用
Advanced science (Weinheim, …
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Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis.
Meta-Analysis
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3 件の引用
Advances in experimental …
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Molecules (Basel, Switzerland)
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85 件の引用
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 件の引用
European journal of …
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40 件の引用
Complementary therapies in …
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30 件の引用
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
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8 件の引用
Clinical gastroenterology and …
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49 件の引用
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 件の引用
Nutrients
2020
30 件の引用
Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials.
Meta-Analysis
Journal of gastroenterology …
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30 件の引用
Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis.
Meta-Analysis
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Therapeutic advances in …
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21 件の引用
Medicine
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4 件の引用
International journal of …
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Nutrients
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Critical reviews in …
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Journal of medicinal …
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17 件の引用
Immunopharmacology and immunotoxicology
2018
96 件の引用
Gastroenterology clinics of …
2018
67 件の引用
Nutrients
2018
46 件の引用
Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis.
Meta-Analysis
The American journal …
2018
30 件の引用
Medical principles and …
2017
45 件の引用
Acta medica Indonesiana
2017
24 件の引用
The Medical clinics …
2017
9 件の引用
Ugeskrift for laeger
2017
Annals of gastroenterology
2016
41 件の引用
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 件の引用
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 件の引用
Annals of gastroenterology
2015
135 件の引用
Molecules (Basel, Switzerland)
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122 件の引用
World journal of …
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23 件の引用
The AAPS journal
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1866 件の引用
Alimentary pharmacology & …
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128 件の引用
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
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103 件の引用
Food & function
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Revista de gastroenterologia …
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2 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
上限量： Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| Varying dosages | -- | Positive | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
報告されている副作用
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
既知の相互作用
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
耐容上限摂取量： Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Curcumin help with Ulcerative Colitis (UC)?
Based on 5 studies with 400 participants, there is moderate evidence from clinical studies that Curcumin may support Ulcerative Colitis (UC) management. Our evidence grade is B (Good Evidence).
How much Curcumin should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Ulcerative Colitis (UC)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Ulcerative Colitis (UC)
Curcumin 他の症状・状態について
References
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