Lactobacillus plantarum per Irritable Bowel Syndrome (IBS)
B Evidenze Almeno un trial randomizzato lo supporta, con risultati per lo più coerenti.Reduces abdominal pain and bloating in IBS. Multiple RCTs show significant improvement in global IBS symptom scores. Strain-specific evidence for 299v is relatively strong.
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B
In sintesi
Reduces abdominal pain and bloating in IBS. Multiple RCTs show significant improvement in global IBS symptom scores. Strain-specific evidence for 299v is relatively strong.
Key Study Findings
Meta-Analysis
n=3154
Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …
Dose: None
vs: placebo
Outcome: quality of life, depression, and anxiety in IBS …
Effetto: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression)
None
Popolazione: patients with irritable bowel syndrome
Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None
vs: placebo
Outcome: improvement in key IBS symptoms
Effetto: None
None
Popolazione: patients with IBS from 32 RCTs evaluating 10 probiotic strains
Other
n=25
4 weeks
Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 …
Dose: Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917
vs: phosphate-buffered saline (PBS)
Outcome: visceral hypersensitivity (abdominal withdrawal reflex scores)
Effetto: None
p<0.05
Popolazione: female rats with water avoidance stress-induced IBS-D model
Other
Lactobacillus plantarum and Galacto-Oligosaccharides Synbiotic Relieve Irritable Bowel Syndrome by Reshaping Gut Microbiota and Attenuating …
Dose: 1e9 CFU/day + GOS 10 g/L
vs: IBS model mice without synbiotic
Outcome: IBS symptoms and colonic dysfunction
Effetto: None
<0.05
Popolazione: C. rodentium + WAS IBS mouse model
Other
Synergistic Modulation of the Gut-Brain-Immune Axis by a Dual Lactobacillus Combination in a Murine IBS …
Dose: None
vs: Single-strain or vehicle control
Outcome: IBS-like symptoms in zymosan-induced mouse model
Effetto: None
None
Popolazione: Zymosan-induced IBS mouse model
Randomized Controlled Trial
n=61
12 weeks
Double-blind
Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel …
Dose: None
vs: Placebo
Outcome: IBS-SSS (100-point reduction)
Effetto: 45% active vs 33% placebo (P=0.42)
P=0.42
Popolazione: IBD patients with IBS symptoms in remission
Key Statistics
5
Studi
800
Partecipanti
↑
Positive
B
Grado
Referenced Papers
Journal of clinical …
2026
European journal of …
2026
Journal of the …
2026
Nutrients
2025
6 citazioni
World journal of …
2025
2 citazioni
Journal of microbiology …
2025
1 citazioni
Beneficial microbes
2025
Food & function
2024
14 citazioni
Minerva gastroenterology
2024
4 citazioni
Journal of neurogastroenterology …
2024
4 citazioni
Frontiers in medicine
2024
2 citazioni
Journal of applied …
2024
1 citazioni
Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis.
Meta-Analysis
Gastroenterology
2023
75 citazioni
Drugs
2023
21 citazioni
Food & nutrition …
2022
26 citazioni
Journal of neurogastroenterology …
2022
21 citazioni
Nutrients
2022
20 citazioni
Frontiers in nutrition
2022
13 citazioni
JPMA. The Journal …
2022
6 citazioni
Beneficial microbes
2021
69 citazioni
Frontiers in immunology
2021
67 citazioni
European journal of …
2021
49 citazioni
Microorganisms
2021
47 citazioni
Digestive diseases (Basel, …
2021
28 citazioni
Food & function
2021
21 citazioni
Frontiers in pain …
2021
15 citazioni
Przeglad gastroenterologiczny
2021
14 citazioni
Central-European journal of …
2020
38 citazioni
The primary care …
2020
32 citazioni
Nutrition journal
2020
28 citazioni
European review for …
2020
21 citazioni
Probiotics and antimicrobial …
2020
21 citazioni
Probiotics and antimicrobial …
2019
43 citazioni
Foods (Basel, Switzerland)
2019
21 citazioni
Acta bio-medica : …
2019
6 citazioni
Food & function
2018
77 citazioni
Digestive diseases and …
2018
57 citazioni
Applied microbiology and …
2015
107 citazioni
Nutrition (Burbank, Los …
2014
64 citazioni
Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis.
Meta-Analysis
Revista espanola de …
2013
102 citazioni
PloS one
2012
445 citazioni
World journal of …
2012
277 citazioni
Journal of clinical …
2012
207 citazioni
Polski merkuriusz lekarski …
2012
8 citazioni
Revista espanola de …
2009
1 citazioni
Use of diet and probiotic therapy in the irritable bowel syndrome: analysis of the literature.
Review
Journal of clinical …
2005
54 citazioni
Zeitschrift fur Gastroenterologie
2005
17 citazioni
Journal of clinical …
2004
205 citazioni
Anaerobe
2004
40 citazioni
Digestive diseases and …
2002
250 citazioni
Current treatment options …
2002
5 citazioni
European journal of …
2001
518 citazioni
The American journal …
2000
648 citazioni
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- general:
- 10-20 billion CFU/day
- ibssupport:
- 10 billion CFU/day (299v strain) for 4 weeks minimum
Limite massimo: Well-tolerated up to 20 billion CFU/day in clinical trials
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Positive | 3154 |
| None | -- | Positive | -- |
| Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 | 4 weeks | Positive | 25 |
| 1e9 CFU/day + GOS 10 g/L | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 12 weeks | Neutral | 61 |
| None | 8 weeks | Positive | 1098 |
| 10 μg | 6 weeks | Positive | 246 |
Momento migliore per l'assunzione: On an empty stomach or before meals
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional loose stools
- ⚠ Histamine-related symptoms in sensitive individuals (histamine-producing species)
- ⚠ Very rare: bacteremia in immunocompromised individuals
Interazioni note
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (theoretical risk in immunocompromised patients)
- ● Histamine-intolerance medications (L. plantarum may produce biogenic amines)
Livello di assunzione massimo tollerabile: Well-tolerated up to 20 billion CFU/day in clinical trials
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Lactobacillus plantarum help with Irritable Bowel Syndrome (IBS)?
Based on 5 studies with 800 participants, there is moderate evidence from clinical studies that Lactobacillus plantarum may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).
How much Lactobacillus plantarum should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus plantarum?
Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Histamine-related symptoms in sensitive individuals (histamine-producing species), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus plantarum and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.
Related Evidence
Altri ingredienti per Irritable Bowel Syndrome (IBS)
References
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