Bifidobacterium breve per Irritable Bowel Syndrome (IBS)

Q: Does Bifidobacterium breve help with Irritable Bowel Syndrome (IBS)?

Based on 2 studies with 150 participants, there is preliminary evidence that needs more research that Bifidobacterium breve may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is D (Very Early Research).

Q: How much Bifidobacterium breve should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Bifidobacterium breve?

Reported side effects may include Mild gas during initial use, Occasional loose stools in infants (transient), Rare abdominal discomfort, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Bifidobacterium breve and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Limited data from small studies. Preliminary evidence for symptom improvement.

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In sintesi

Limited data from small studies. Preliminary evidence for symptom improvement.

Key Study Findings

Review

Compendium of Bifidobacterium-based probiotics: characteristics and therapeutic impact on human diseases.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: None

Other n=1098 8 weeks Open-label

A multicenter real-world, open-label study assessing the impact of a probiotic mixture on symptoms of …

Dose: None vs: None (single-arm open-label) Outcome: Treatment success for abdominal pain and bloating Effetto: 73% pain, 81.9% bloating success at T1 <0.001

Popolazione: IBS patients from 52 Italian gastroenterologists

Randomized Controlled Trial n=61 8 weeks Double-blind

Eight weeks of treatment with probiotic Bifidobacterium breve, Bif195 lowers fatigue scores in patients with …

Dose: None vs: Placebo Outcome: IBS-SSS symptom severity score change Effetto: None None

Popolazione: Patients with moderate-severe diarrhea-predominant IBS

Randomized Controlled Trial 4 weeks

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group …

Dose: 2 g vs: Placebo Outcome: Constipation symptoms Effetto: None P = 0.005

Popolazione: IBS patients

Review

Postbiotics: A new member in the biotics family.

Dose: None vs: None Outcome: Clinical applications overview Effetto: None None

Popolazione: General population (review)

In Vitro

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal …

Dose: None vs: None Outcome: Colitis severity Effetto: None None

Popolazione: Crohn's disease patients

Key Statistics

Studi

150

Partecipanti

↑

Positive

Grado

Referenced Papers

Compendium of Bifidobacterium-based probiotics: characteristics and therapeutic impact on human diseases. Review

Microbiome research reports 2025 16 citazioni

A multicenter real-world, open-label study assessing the impact of a probiotic mixture on symptoms of irritable bowel syndrome in adults. Other

Beneficial microbes 2025

Eight weeks of treatment with probiotic Bifidobacterium breve, Bif195 lowers fatigue scores in patients with diarrhoea-predominant irritable bowel syndrome: results … Other

Frontiers in nutrition 2025

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal Extracts in an In Vitro … Other

The Yale journal … 2024 5 citazioni

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. Other

Journal of neurogastroenterology … 2024 4 citazioni

Postbiotics: A new member in the biotics family. Other

Archivos argentinos de … 2024 3 citazioni

Gut Microbiome Alterations Following Oral Serum-Derived Bovine Immunoglobulin Administration in the Management of Dysbiosis. Other

Cureus 2024 1 citazioni

Alternation of the gut microbiota in irritable bowel syndrome: an integrated analysis based on multicenter amplicon sequencing data. Other

Journal of translational … 2023 30 citazioni

Dose-Response Efficacy and Mechanisms of Orally Administered Bifidobacterium breve CCFM683 on IMQ-Induced Psoriasis in Mice. Other

Nutrients 2023 19 citazioni

Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: … Other

Journal of neurogastroenterology … 2022 21 citazioni

Immunomodulatory Effects of Bifidobacterium spp. and Use of Bifidobacterium breve and Bifidobacterium longum on Acute Diarrhea in Children. Other

Journal of microbiology … 2022 15 citazioni

Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome. Other

Scientific reports 2022 14 citazioni

Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. Systematic Review

Journal of clinical … 2018 34 citazioni

Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a … Other

Journal of clinical … 2015 62 citazioni

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Meta-Analysis

Revista espanola de … 2013 102 citazioni

The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, … RCT

Journal of clinical … 2012 207 citazioni

Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel … Other

PloS one 2012 31 citazioni

BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels? Other

Beneficial microbes 2011 89 citazioni

The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat. Other

Neurogastroenterology and motility 2010 213 citazioni

Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes. RCT

BMC gastroenterology 2010 91 citazioni

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome. RCT

Alimentary pharmacology & … 2007 102 citazioni

Clinical studies on alleviating the symptoms of irritable bowel syndrome. RCT

Asia Pacific journal … 2006

A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. RCT

Alimentary pharmacology & … 2005 398 citazioni

Probiotics in the treatment of irritable bowel syndrome. RCT

Journal of clinical … 2004 205 citazioni

Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome … Other

Research in microbiology 2001 201 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 1-10 billion CFU/day
adultgisupport:: 5-10 billion CFU/day
neonatalsupport:: 1-5 billion CFU/day (as directed by pediatrician)

Limite massimo: Well-tolerated up to 10 billion CFU/day in clinical trials

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Mixed	--
None	8 weeks	Positive	1098
None	8 weeks	Neutral	61
2 g	4 weeks	Mixed	--
None	--	Positive	--
None	--	Positive	--
Serum-derived bovine immunoglobulin (SBI)	--	Positive	--
None	--	Positive	--

Momento migliore per l'assunzione: Before meals or on empty stomach; for infants, mix with breast milk or formula

Safety & Side Effects

Effetti collaterali segnalati

⚠ Mild gas during initial use
⚠ Occasional loose stools in infants (transient)
⚠ Rare abdominal discomfort
⚠ Very rare: bacteremia in immunocompromised individuals

Interazioni note

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (use with caution in immunocompromised patients)

Livello di assunzione massimo tollerabile: Well-tolerated up to 10 billion CFU/day in clinical trials

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Bifidobacterium breve help with Irritable Bowel Syndrome (IBS)?

Based on 2 studies with 150 participants, there is preliminary evidence that needs more research that Bifidobacterium breve may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is D (Very Early Research).

How much Bifidobacterium breve should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Bifidobacterium breve?

Reported side effects may include Mild gas during initial use, Occasional loose stools in infants (transient), Rare abdominal discomfort, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Bifidobacterium breve and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

Verdetto rapido

Limited data from small studies. Preliminary evidence for symptom improvement.

Evidence Strength30%

Low confidence

Analisi degli studi

RCT (6)Meta (1)Other (0)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Irritable Bowel Syndrome (IBS)

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.