Curcumin 用于 Ulcerative Colitis (UC)
BMulticenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
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B
结论
Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
Key Study Findings
Systematic Review
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Dose: None
vs: placebo or standard therapy
Outcome: ulcerative colitis outcomes (18 outcomes across 7 SR/MAs)
效果: None
None
研究人群: patients with ulcerative colitis
Other
Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis.
Dose: None
vs: untreated colitis controls
Outcome: mitigation of colitis symptoms (ROS scavenging, barrier restoration, …
效果: None
None
研究人群: UC animal model and oxidatively stressed colon cells
Review
Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Systematic Review
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Dose: None
vs: Various comparators
Outcome: Multiple health outcomes
效果: None
None
研究人群: Human subjects across 25 meta-analyses
Review
Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
In Vitro
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
Dose: None
vs: DSS-induced UC mice
Outcome: UC inflammation via SphK1/NF-kB pathway
效果: None
None
研究人群: DSS-induced UC murine model
Key Statistics
5
研究数量
400
受试者
↑
Positive
B
等级
Referenced Papers
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Systematic Review
Nutrition reviews
2026
ACS nano
2025
29 次引用
Frontiers in immunology
2025
20 次引用
Naunyn-Schmiedeberg's archives of …
2025
14 次引用
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Systematic Review
Frontiers in pharmacology
2025
10 次引用
BioFactors (Oxford, England)
2025
9 次引用
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 次引用
European journal of …
2025
7 次引用
Explore (New York, …
2025
5 次引用
Journal of agricultural …
2025
3 次引用
Materials today. Bio
2025
3 次引用
Frontiers in nutrition
2025
2 次引用
Frontiers in pharmacology
2025
1 次引用
Cellular and molecular …
2025
Nutrients
2025
International journal of …
2025
Clinical gastroenterology and …
2024
52 次引用
Food research international …
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44 次引用
Advanced materials (Deerfield …
2024
37 次引用
Journal of pharmaceutical …
2024
29 次引用
International journal of …
2024
27 次引用
Nutrients
2024
23 次引用
ACS omega
2024
16 次引用
Frontiers in pediatrics
2024
4 次引用
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 次引用
World journal of …
2024
Frontiers in endocrinology
2023
253 次引用
Metabolites
2023
134 次引用
Advanced science (Weinheim, …
2023
90 次引用
Journal of nanobiotechnology
2023
63 次引用
Pharmaceuticals (Basel, Switzerland)
2023
18 次引用
Toxicology mechanisms and …
2023
5 次引用
Journal of nanobiotechnology
2022
206 次引用
International journal of …
2022
142 次引用
The American journal …
2022
86 次引用
Frontiers in immunology
2022
68 次引用
Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis.
Meta-Analysis
Journal of ethnopharmacology
2022
39 次引用
American family physician
2022
38 次引用
Nutrients
2022
19 次引用
Turkish journal of …
2022
3 次引用
Advances in experimental …
2021
87 次引用
Molecules (Basel, Switzerland)
2021
85 次引用
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 次引用
European journal of …
2021
40 次引用
Complementary therapies in …
2021
30 次引用
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 次引用
Clinical gastroenterology and …
2020
49 次引用
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 次引用
Nutrients
2020
30 次引用
Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials.
Meta-Analysis
Journal of gastroenterology …
2020
30 次引用
Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis.
Meta-Analysis
Expert review of …
2020
25 次引用
Therapeutic advances in …
2020
21 次引用
Medicine
2020
4 次引用
International journal of …
2019
137 次引用
Nutrients
2019
71 次引用
Critical reviews in …
2019
48 次引用
Journal of medicinal …
2019
17 次引用
Immunopharmacology and immunotoxicology
2018
96 次引用
Gastroenterology clinics of …
2018
67 次引用
Nutrients
2018
46 次引用
Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis.
Meta-Analysis
The American journal …
2018
30 次引用
Medical principles and …
2017
45 次引用
Acta medica Indonesiana
2017
24 次引用
The Medical clinics …
2017
9 次引用
Ugeskrift for laeger
2017
Annals of gastroenterology
2016
41 次引用
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 次引用
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 次引用
Annals of gastroenterology
2015
135 次引用
Molecules (Basel, Switzerland)
2014
122 次引用
World journal of …
2014
23 次引用
The AAPS journal
2013
1866 次引用
Alimentary pharmacology & …
2013
128 次引用
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 次引用
Food & function
2012
151 次引用
Revista de gastroenterologia …
2008
2 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
上限： Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| Varying dosages | -- | Positive | -- |
| None | -- | Positive | -- |
最佳服用时间： With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
已报告的副作用
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
已知相互作用
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
可耐受最高摄入量： Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Curcumin help with Ulcerative Colitis (UC)?
Based on 5 studies with 400 participants, there is moderate evidence from clinical studies that Curcumin may support Ulcerative Colitis (UC) management. Our evidence grade is B (Good Evidence).
How much Curcumin should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Ulcerative Colitis (UC)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Ulcerative Colitis (UC)
Curcumin 用于其他健康状况
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